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WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

WD40域，在真核蛋白质的数量发现，涵盖了包括各种功能适配器/信号转导，mRNA前体细胞骨架组装加工和管理模式；通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长，因此得名WD40；之间的生长激素和WD是一个保守的核心，作为一个稳定的螺旋桨式平台，可以绑定的蛋白可以稳定或可逆性；形式与每个刀片是一个四叶片组成的几个类似结构的螺旋桨，搁浅反平行β-负债表；很少检测副本实例假设，形成了聚大结构，每个WD40重复序列形成了前三个链的一个刀片，并在未来的刀片上链，最后C -末端WD40重复完成了第一WD40重复叶片结构，创造螺旋桨的封闭环结构，对螺旋桨顶部和底部表面残留物，则建议协调与其他蛋白质和/或小配体； 7重复副本存在于相互作用这条路。

It has been tried to in- duce active hydrolytic grop to the ligands of BAT, attempting to use chemical hydrolyses instead of biological hydrolyses to find ide- al brain radiopharmaceuticals. However, because of the immense work, the shortage of funds, only the syntheses of some latents have been done in this theses, and further study is still needed.

本论方中企图通过对BAT类配体引入活泼水解基因，采用化学水解代替生物水解找到理想的脑放射性药物，但因工作量大，消耗经费等问题，本论文中只作了一些潜体的合成，有关工作，有待于进一步研究。

The chiral ligands la-lf were used in the copper catalyzed asymmetric addition of diethylzinc to imines.

第二部分探索了一个新的含氮杂环丙烷的手性膦配体2的合成方法。

Catalytic enantioselective reduction of imines and enamines represents one of the most straightforward and efficient methods for the preparation of chiral amines, which are not only important building blocks of many natrural products and chiral drugs, but also can serve as useful resolution reagents, chiral ligands and chiral catalysts.

中文摘要手性胺不仅是许多天然产物和手性药物的重要结构单元，而且也是非常有用的拆分试剂、手性配体和手性催化剂。

In order to study the effect of PPh_2 group in the application of chiral ligands 4, 5, 7 and 8 to asymmetric reactions, two ferrocenyl amino alcohols 9a and 9b were Scheme 3 synthesized from chiral amino alcohol derived imines 3 (Scheme 3) and applied in the same asymmetric reactions.

为了探讨二苯氧膦基在配体参与不对称催化反应时对其催化活性和选择性的影响，合成了两个手性二茂铁基氨基醇配体9a和9b(Scheme 3)。

Background: Chemokine receptors and their ligands play a key role in the recruitment of leucocytes and can mediate the recruitment of lymphocytes to normal small intestine.

背景：趋化因子受体及其配体是白细胞聚集的关键因素，可介导淋巴细胞聚集到正常的小肠。

You will find that these workunits have twice as many Ligands as the previous ones.

他们的计算量是前面任务的2倍。

One of the important part in the field is the investigation of specific interactions between target proteins and their ligands.

蛋白质与配体之间的相互作用研究是化学遗传学的重要内容之一。

We refer to this strategy as'in vitro evolution'of ligands.

我们把这一策略称之为配基的体外进化。

Then fluorimetric analysis has been used to study complexes 2、8 and their ligands.

对配合物1进行了电化学性质的研究。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了