查询词典 ligand

AR signalling can be activated in HR tumours through several mechanisms. First, activation of intracellular signal transduction pathways can sensitize the AR to castrate levels of androgens. Also, mutations in the AR can change AR ligand specificity, thereby allowing it to be activated by non-steroids or anti-androgens. Finally, overexpression of the wild-type AR sensitizes itself to low concentrations of androgens.

HRPC的AR信号通路活化机制包括：胞内信号传导途径可以增加 AR对于去势治疗后低水平雄激素的敏感性；AR的突变也可改变其对于配体的选择，使得非甾体类激素甚至抗雄激素药物也能够激活AR；此外，野生型AR的过表达也促进了自身对于低浓度雄激素的敏感性。

It has recently been shown that the intracellular region of the Notch receptor is proteolytically cleaved by interaction with the ligand and is translocated into the nucleus.

当Notch受体受到配体的刺激而激活时，它的胞内区在蛋白酶作用下从近膜处裂解，释放出胞内区。

However, fac-Alq3 has been obtained only in the subgram order by sublimation of mixed polymorphs of Alq3 or by thermal conversion of commercial Alq3 followed by acetone and chloroform treatment because synthetic control of a ligand configuration has been considered difficult as a result of the favorable formation of the thermodynamically stable mer isomer.

然而，因子Alq3得到了只有在subgram秩序的升华混合晶型的Alq3或热转换商业Alq3其次是丙酮，氯仿的待遇，因为合成控制配配置一直被认为困难是由于有利的形成的热力学稳定滨海异构体。

In radiolabeled ligand binding experiments, it was found after 12 months of DR, peritoneal macrophages of 20 months old mice displays 〓 AGE receptors per cell 10 times over control, with an affinity constant Ka 〓, one times over control.

本研究通过放射配体结合测定方法，发现8月龄小鼠在限食12个月以后腹腔巨噬细胞的AGE受体数比自由采食对照鼠高出10倍左右，达到每个细胞〓，而结合常数Ka也高出一倍，达到〓。

To study the function of thyroid hormone receptors in osteoblasts and in bone, the nuclear extracts of TRs from human osteoblast-like cell line MG63 and rat calvaria were achieved, and the two main kinetic parameters of TRs, affinity constant and maximal binding capacity, were determined by radio-ligand binding assay and Scatchard plot.

其中MG63和骨组织中TRs的Ka值与文献报告的人类外周血淋巴细胞以及大鼠脑组织和肝脏中TRs的Ka值相比，差别显著，但与文献中其他成骨细胞系的Ka值相近，提示成骨细胞或骨组织中的TRs与THs的结合能力有可能确实低于淋巴细胞、脑组织或肝脏，从而使得THs在骨组织中的作用机制及效果可能有别于其他组织。

The flexible atom receptor model also gives the pseudo receptor model, which indicates possible interactions between receptor and the ligand.

FLARM方法的计算结果还给出了虚拟的受体模型，该模型说明了抑制剂与受体之间可能的相互作用。

A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.

一个在UNC5 和DCC家族受体细胞质领域间的配体门控联合把netrin诱导的发育锥体细胞吸引力转变为了排斥力〉《细胞》第97卷，(1999)： 927-41页。

The fluorescent emission mechanism, and the some factors that affect the energy and the intensities of the fluorescent peaks were studied. The strong powder second harmonic generation efficiencies for complexes (1),(2),(3) and (4) were found. The determination of variable-temperature magnetic susceptibility for complex (3) and complex (5) was performed. The magnetic data were analyzed with their structure properties, and the further information about the magnetic coupling capacity of Carbamyldicyanomethanide as bridging ligand was obtained.

测试了配合物(1)，(2)，(3)，(4)的荧光光谱，从配体的结构特点等方面研究了该荧光光谱的产生机理，研究了影响荧光谱峰能量及强度的因素；发现了配合物(1)，(2)，(3)，(4)显示有强的二阶非线性倍频效应；测试了配合物(3)和(5)的变温磁化率，对所得磁数据进行了结构性质分析，进一步获得了甲氨酰二氰基甲基阴离子作为桥联配体的磁耦合信息。

In-situ synthesis process was used to prepare copper nanoparticles and coppernanoparticles-polyethylene glycol oil solution by reduction of copper acetate by glycol in polyethylene glycol containing amido ligand as dispersant.

采用原位合成法以聚乙二醇400作为反应介质，以氢氧化钠和氨基配体作为分散剂，用乙二醇还原六水合乙酸铜制备出纳米Cu粉和纳米Cu聚乙二醇溶液，用X射线衍射仪和透射电子显微镜表征其结构，在四球摩擦磨损试验机上评价了含不同质量分数纳米铜粉的聚乙二醇溶液的摩擦磨损性能，并与分散剂进行对比。

This made Notch ligand Delta a potential ideal candidates for the self-renewal and expansion of stem cells. The tentative plan was firstly applied in hematopoietic stem cells, and obtained encouraging results.

最近有人提出利用Notch信号的这种&分化抑制作用&，对干细胞的增殖和分化进行调控的设想，并在造血干细胞研究方面取得了一些令人鼓舞的结果。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。