查询词典 ligand

So, when designing novel intercalating ligand, the charge distribution and streic interaction should be emphasized. 4. Comparison on the modeling of DNA helix with different conditions.

这就提示我们，采用esff力场在水溶液环境中对本论文中的系列作用体系进行模拟是合理的，但是在真空环境中可能会出现结构损坏，进而影响到对识别结果的深入分析。

In this paper, the stable Au complexes are classified according to the coordination atoms and their characteristic structure. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationship, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexes and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征，按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果：配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大；介绍了用于检测三价金配合物与可能的生物靶分子之间的相互作用的多种物理和生物学方法，重点关注了相互作用的模式，如嵌入/静电吸引/共价结合等，并解释了三价金配合物抗肿瘤活性的原因。

In this paper, the stable Au complexes are classified according to the coordination atoms and their structural characteristics. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationships, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexe and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征，按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果：配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大；介绍了用于检测三价金配合物与可能的生物靶分子之间相互作用的多种物理和生物学方法，重点关注了相互作用的模式，如嵌入/静电吸引/共价结合等，并解释了三价金配合物抗肿瘤活性的原因。

RANK ligand has been shown in preious studies to be an important inflammatory protein that can lead to bone loss through actiation of bone resorbing cells.

而这个RANK配基在目前的研究中被认为是有一个重要的炎症蛋白质，它会激活骨吸收细胞而造成骨丢失。

The sensitizer sensitizes TiO2 over a notably broad spectral range due to its intense metal-to-ligand charge-transfer bands at 537 and 418 nm.

该配合物在537和418 nm处有强的金属－配体电荷转移吸收带，可以在很宽带光谱范围内对纳米二氧化钛薄膜进行敏化。

AR signalling can be activated in HR tumours through several mechanisms. First, activation of intracellular signal transduction pathways can sensitize the AR to castrate levels of androgens. Also, mutations in the AR can change AR ligand specificity, thereby allowing it to be activated by non-steroids or anti-androgens. Finally, overexpression of the wild-type AR sensitizes itself to low concentrations of androgens.

HRPC的AR信号通路活化机制包括：胞内信号传导途径可以增加 AR对于去势治疗后低水平雄激素的敏感性；AR的突变也可改变其对于配体的选择，使得非甾体类激素甚至抗雄激素药物也能够激活AR；此外，野生型AR的过表达也促进了自身对于低浓度雄激素的敏感性。

It has recently been shown that the intracellular region of the Notch receptor is proteolytically cleaved by interaction with the ligand and is translocated into the nucleus.

当Notch受体受到配体的刺激而激活时，它的胞内区在蛋白酶作用下从近膜处裂解，释放出胞内区。

However, fac-Alq3 has been obtained only in the subgram order by sublimation of mixed polymorphs of Alq3 or by thermal conversion of commercial Alq3 followed by acetone and chloroform treatment because synthetic control of a ligand configuration has been considered difficult as a result of the favorable formation of the thermodynamically stable mer isomer.

然而，因子Alq3得到了只有在subgram秩序的升华混合晶型的Alq3或热转换商业Alq3其次是丙酮，氯仿的待遇，因为合成控制配配置一直被认为困难是由于有利的形成的热力学稳定滨海异构体。

In radiolabeled ligand binding experiments, it was found after 12 months of DR, peritoneal macrophages of 20 months old mice displays 〓 AGE receptors per cell 10 times over control, with an affinity constant Ka 〓, one times over control.

本研究通过放射配体结合测定方法，发现8月龄小鼠在限食12个月以后腹腔巨噬细胞的AGE受体数比自由采食对照鼠高出10倍左右，达到每个细胞〓，而结合常数Ka也高出一倍，达到〓。

To study the function of thyroid hormone receptors in osteoblasts and in bone, the nuclear extracts of TRs from human osteoblast-like cell line MG63 and rat calvaria were achieved, and the two main kinetic parameters of TRs, affinity constant and maximal binding capacity, were determined by radio-ligand binding assay and Scatchard plot.

其中MG63和骨组织中TRs的Ka值与文献报告的人类外周血淋巴细胞以及大鼠脑组织和肝脏中TRs的Ka值相比，差别显著，但与文献中其他成骨细胞系的Ka值相近，提示成骨细胞或骨组织中的TRs与THs的结合能力有可能确实低于淋巴细胞、脑组织或肝脏，从而使得THs在骨组织中的作用机制及效果可能有别于其他组织。

Now she was hungry and angry.She began to smoulder.

现在她又饿又气，她开始流露难以抑制的怒火。

You have placed our iniquities before You, Our secret sins in the light of Your presence.

诗90：8 你将我们的罪孽摆在你面前、将我们的隐恶摆在你面光之中。