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Radio-ligand binding assay was applied to determine the maximum binding and affinity changes of nicotinic acetylcholine receptor on five weeks old male Sprague-Dawley rat's lateral pterygoid muscle and superficial masseter muscle after the function mandibular advancement.

本研究在以往研究的基础上，首次对功能矫形的神经肌肉调控机理进行探索。应用放射受体分析法，从膜受体蛋白分子水平定量研究功能矫形前伸青春期SD大鼠（5周龄）下颌后，下颌前伸肌细胞膜烟碱样乙酰胆碱受体最大结合容量和亲和性的变化。

And the mechanism of ATRP is discussed from the view of complex-catalytic reaction. It is deduced that the active center in ATRP is not pure radical but complex active center, which maybe a complex with radical and complex ion. The structure of active center may have a "bridge"structure formed through propaganating radical and transition metal ion, and the active center exists in a"cage"generated by ligand-transition metal ion-organic halide and monomer or solvent.

论文运用基团贡献理论对一些实验现象和结果进行了讨论和分析，并结合研究结果对络合催化引发原子转移自由基聚合反应的机理进行了初步的探讨，认为：过渡金属化合物与有机配体参与的络合催化引发原子转移自由基聚合反应中，聚合反应的活性中心不是纯粹的自由基活性中心，而是与过渡金属相结合的、有着某种"笼"结构存在的复合式活性中心，同时该活性中心以自由基特性为主，同时兼具某种程度的其它活性中心特征（如阳离子和络合聚合活性中心）。

Molecular docking study of telomerase TMPYP4 quadruplex stabilization role Abstract: The purpose of ligand TMPyP4 to find telomerase TMPyP4 quadruplex in the best mode.

分子对接法研究TMPYP4对端粒酶四链体的稳定化作用摘要：目的以TMPyP4为配体，寻找TMPyP4在端粒酶四链体上的最佳作用方式。

From the calculations, it can be found that the van der Waals interactions, the hydrophobic interactions, as well as the H-bonding interactions are crucial for the ligand binding. The 4-phenylamino group can produce strong van der Waals adn hydrophobic interactions with the nonpolar side chains of the residues deep in the binding cleft. The R^1 and R^2 substituents on the bicyclic chromophore can also produce strong van der Waals and hydrophobic interactions with the residues located at the exterior part of the binding pocket. Moreover, the two N atoms of the quinazoline can form H-bonds with EGFR, which will produce significant contribution to biological activities. The calculated nonbonded interactions between anilinoquinazolines and EGFR, as well as the information obtained from the predicted complexes, can interpret the structure-activities of the inhibitors well, which can afford us important information for structure-based drug design.

从模拟结果得到的抑制剂和靶酶之间的相互作用模式表明范德华相互作用、疏水相互作用以及氢键相互作用对抑制剂的活性都有重要的影响，抑制剂的苯胺部分位于活性口袋的底部，能够与受体残基的非极性侧链产生很强的范德华和疏水相互作用，抑制剂双环上的取代基团也能和活性口袋外部的部分残基形成一定的范德华和疏水性相互作用，而抑制剂喹唑啉环上的氮原子能和周围的残基形成较强的氢键相互作用，对抑制剂的活性有较大的影响，计算得到抑制剂和靶酶之间的非键相互作用能以及抑制剂和靶酶之间的相互作用信息能够很好地解释抑制剂活性和结构的关系，为全新抑制剂的设计提供了重要的结构信息。

These Ir complexes, bearing the chromophore ligand pyridine, isoquinoline and quinazoline respectively, exhibit green-to-red photoluminescence with moderate to high quantum efficiencies in the degassed fluid state and bright emission in solid state.

首先，描述一系列含P^O辅助基的铱金属错合物发光材料之设计概念，这些铱金属错合物藉由pyridine， isoquinoline和quinazoline不同的发光基团调控，磷光放光可以由绿色改变至红色，不论在除氧的溶液态以及固态都有相当不错的量子效率，并且具有效率高、寿命长的优点。

We used the reported chiral ligand QD-4 derived from quinidine to catalyze the reaction of aldehydes and methyl vinyl ketone in the presence of various additives and found that the highest e.

用喹尼叮衍生物QD-4分别催化醛和丁烯酮以及醛和丙烯酸-萘酚酯的不对称Baylis-Hillman反应，通过改变添加剂和优化反应条件，最终分别取得了最高为49％和70％的e.e值。

The effects of racemate initial concentration, volume ratio of surfactant to organic solvent, pH value in internal or external phase, pH gradient from external to internal phase, ligand metallicion and system temperature on the performances of chiral separation were discussed.

摘 要：研究在含有Cu2+和N-n-十二烷基-L-脯氨酸手性配体的乳状液膜体系中手性萃取分离氧氟沙星对映体的效果，以及外消旋体的初始浓度、表面活性剂与有机溶剂的体积配比、内外水相pH值、从外水相到内水相pH值梯度变化以及配位金属离子与体系温度对液膜手性分离性能的影响。

Methods Proteins existed in adult Schistosoma japonicum membrane were extracted by Triton X-100 and purified through reverse-phase high performance liquid chromatography,and the main protein peaks were then collected separately. 125 I-LDL of human plasma as the ligand, through the radioautography and radioligand binding assay, the protein which can bind human serum 125 I-LDL specifically was identified.

自人工感染家兔的肠系膜下静脉取日本血吸虫成虫，用非离子去污剂TritonX 10 0抽提出日本血吸虫成虫表膜蛋白，反相高效液相色谱进行分离纯化后，收集各主要分离蛋白峰，以12 5I标记的人血浆低密度脂蛋白作为放射性配体，经放射性自显影及放射性受体配体结合分析鉴定能与人血浆12 5I LDL特异结合的蛋白。

The protein had the specificity on substrate recognition, which could decompose 3,4-dihydroxybenzoic acid to catechol but not 2,4-dihydroxy- benzoic acid to resorcin. The ligand at C-3 site of benzene ring had no effect on enzyme activity.

蛋白质还具有底物识别的特异性，能够催化3，4-二羟基苯甲酸转化为邻苯二酚，而不能催化2，4-二羟基苯甲酸转化为间苯二酚，这表明苯环上3'位的配基对酶活无影响。

In the rhombohedron, each top site is occupied by a pair of ligand-unsupported Ag atoms which are surrounded by six phenol groups in an ethane-like structure. The phenol groups at another ends of the ligands bridge the rhombohedrons into novel non-interpenetrating three-dimensional network.

在每个棱柱体内，每个顶点由无桥连配体支持的、周围的六个酚羟基以一种不寻常的、类似于乙烷分子结构的扭曲方式排列的一对 Ag 原子占据，配体另一端酚羟基将棱面体连接成新颖的非穿插的具有棱形通道(沿 a 和 b 轴方向)的三维网络结构。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。