查询词典 leukemic

Methods Real-time quantitative retroverse polymerase chain reaction method was used for detecting RbAp46 expression levels in BM cells of 140 patients with acute leukemia,13 with chronic myelogenous leukemia in chronic phase, 7 with CML in blast crisis and 32 with non-leukemic disorders.

方法建立实时定量RTPCR方法，利用SYBRGreenⅠ染料检测140例急性白血病、13例慢性粒细胞白血病慢性期和7例CML急变期患者以及32例非白血病患者骨髓细胞RbAp46基因的表达水平。

Our results indicate that 1 NSC606985, at nanomolar level, can effectively induce apoptosis in AML cells NB4 and U937 and significantly inhibit the proliferation without cell death in breakpoint cluster region–Abelson murine leukemia kinase-carrying leukemic K562 cells; 2 At such low concentrations, this agent also significantly inhibits the clonogenic activity of hematopoietic progenitors from patients with AML; 3 For apoptosis induction, NSC606985 rapidly induces the proteolytic activation of protein kinase Cδ with loss of mitochondrial transmembrane potential and caspase-3 activation; 4 Co-treatment with rottlerin, a PKCδ-specific inhibitor, completely blocks NSC606985-induced mitochondrial m loss and caspase-3 activation, while the

结果显示：(1)纳摩尔浓度的NSC606985即可有效诱导AML细胞系NB4和U937细胞凋亡并显著抑制含有bcr-abl融合蛋白激酶的K562细胞的增殖；(2)低浓度的NSC606985也显著抑制来自AML病人骨髓的新鲜白血病细胞的克隆形成能力；(3)除了迅速诱导线粒体跨膜电位的崩塌及Caspase-3的活化外，NSC60698也导致蛋白激酶Cδ的水解激活；(4)PKCδ特异的抑制剂rottlerin能够完全抑制NSC606985诱导的线粒体跨膜电位的崩塌和Caspase-3的活化，而Caspase-3特异的抑制剂z-DEVD-fmk仅能部分削弱PKCδ的活化及细胞的凋亡；(5)以移植PML-RARα转基因小鼠产生的白血病细胞建立的模型研究了该化合物对白血病可能的治疗作用。

Normal lymphocytes may be distinguished from leukemic lymphocytes. This method also helps to subclassify cell types, which may, in turn, help the physician to decide on the best treatment to apply in that type of leukemia or lymphoma.

这种方法也能够用以区分细胞亚型，可帮助内科医师针对不同类型的白血病或淋巴瘤制定最佳的治疗方案。

Normal lymphocytes may be distinguished from leukemic lymphocytes. This method also helps to subclassify cell types, which may, in turn, help the physician to decide on the best treatment to apply in that type of leukemia or lymphoma.

这种方法同样能够帮助区分细胞亚型，随后就能进一步帮助内科医师制定最佳的治疗方案。

Inthis study, in order to investigate the function of tryptase on the mechanism of acuteleukemia, tryptase expressed by leukemic cells were determined in 61 patients withacute leukemias.

本实验检测了61例急性白血病患者白血病细胞类胰蛋白酶的表达情况，进一步探讨了类胰蛋白酶在急性白血病的发生发展中的作用。

The treatment of leukemic cell with a longterm, intermittent,singular, unefficient chemotherapeutic agents could induce multi-drug resistant cells. Interleukin-4 can reverse the multi-drug resistance by inhibiting the expression of p-gp and increasing the quantity of intracellular chemotherapeutic agents in tumor cells. The effects were probably related to the inhibition of the PKC activity.

长期、间断、单一、不足量的化疗可导致 MDR；IL-4 可通过抑制肿瘤细胞的 p-gp表达，增加化疗药物在肿瘤细胞内的聚集而逆转白血病细胞的MDR，此作用可能与抑制 PKC的活性有关。

Importantly, YM529 prolonged the survival of NOD/SCID mice engrafted with human primary leukemic cells.

更重要的是，YM529延长植入人类原发性白血病细胞NOD/SCID小鼠的生存时间。

Outside the cells, it moonlights as autocrine mobility factor involved in cancer metastasis, neurolukin supporting the survival of specific neurons, and maturation factor mediating the differentiation of myeloid leukemic HL-60 cells to terminal monocytic cells.

在细胞外，PGI是一种肿瘤自泌移动因子和肿瘤转移有关，也是一种神经白介素和促分化成熟介子，分别具有支持脊髓及感觉神经元存活的能力和诱导白血病细胞HL-60成为单核白血球。

The marrow between the pink bone trabeculae seen here is nearly 100% cellular, and it consists of leukemic cells of acute lymphocytic leukemia that have virtually replaced or suppressed normal hematopoiesis .

如图可见粉红色的骨小梁之间的骨髓几乎100%是细胞，是由急性淋巴母细胞性白血病的白血病细胞构成，这些细胞实际上替代或抑制了正常的造血作用。

So, berbamine could significantly induce apoptosis in those four kinds of leukemic cells in a time-and-concentration-dependent manner in vitro.

以上结果表明，小檗胺除对已报道的HL〓细胞外，还能显著地诱导其它类型的白血病细胞凋亡(如K〓、Jurkat、NB〓细胞)，并呈明显的浓度-时间依赖关系。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。