查询词典 leukemic

Objective:To explove the mechanism of BCB treating leukemia and investigate the apoptosis of leukemic cells induced by BCB.and its action on cell cycle.

为探讨乳香抗白血病的作用机制，研究乳香诱导急性早幼粒细胞白血病细胞凋亡与细胞周期关系。

Objective: To study the expression of CXCR4 in acute leukemic cells and its clinical significance.

目的：探讨急性白血病细胞上CXCR4的表达及临床意义。

Objective:To investigate the role of purinergic P2z receptors in human leukemic lymphocyte apoptosis induced by extracellular adenosine triphosphate.

目的：研究嘌呤能P2z受体在介导慢性淋巴细胞白血病细胞凋亡中的作用。

The results revealed that two cases of amitosis existed in acute myeloid leukemic cells.

结果发现在 2例标本中存在白血病细胞的无丝分裂现象。

High expression of cellular asparagine synthetase is a causative factor for the resistance of leukemic cell to Lasparaginase therapy.

细胞内门冬酰胺合成酶（asparagines synthetase， AS）的表达水平与白血病细胞对左旋门冬酰胺酶耐药有关。

Methods The cell growth inhibiting rate, LDLR activity in acute leukemia patients and the influence of HMG-CoA reduct ase inhibiter atorvastatin on leukemic cell proliferation were detected by MTT method. HMG-CoA reductase activities of leukemic cells were analysed by ultraviolet spectrophotometry.

用四氮甲唑蓝比色法检测AL患者的细胞生长抑制率、LDLR活性、HMG-CoA还原酶抑制剂阿托伐他汀对白血病细胞增殖作用的影响；紫外分光光度法测定白血病细胞HMG-CoA还原酶活性。

Results Analysis of the expression of proteins of JAK2 in leukemic blasts, there was no detectable constitutive expression of phosphorylated JAK2 in all the AML samples analyzed; Furthermore, we could detect a constitutive activation of STAT 3 by immunoprecipitation of the targeted protein in primary leukemic blasts from 3 of 11 AML patients without any cytokine treatment; Pretreatment clinical characteristics, and treatment regimens did not differ significantly between patients with and without constitutive STAT3 activity, there was not significant relation between the constitutive activation of STAT3 and the FAB subvariety and chromosome karyotype; However, the 3 patients with constitutive STAT3 activity seemed to have adverse treatment outcome, one did not show remission, the other two patients relapsed shortly after remission; Consistent with the above-mentioned result, leukemic blasts from the 3 samples with constitutive expression of STAT3 showed higher percentage of spontaneous apoptosis and S-phase cells.

在实验研究基础上，本研究进一步运用免疫沉淀和Western Blot印迹方法，检测AML患者原代细胞JAK2和STAT3活化情况，并分析了STAT3活化与AML患者预后有关指标改变的关系。结果我们的初步研究发现，11例AML患者中，有3例呈现STAT3组成型活化（STAT3阳性，下同），无一例呈JAK2组成型活化。上述3例STAT3组成型活化与FAB分型和染色体核型改变未见明显相关性；在此3例患者中，1例未取得缓解，另外2例虽然取得短暂缓解，但均在二个月内复发。上述3例STAT3阳性AML患者S期白血病细胞百分率数值较组高，而凋亡率数值较低。

By using this antisense MDR1 modified cell line, K562MDR/LASSN cells , we will further study the effects of MDR1 antisense RNA on the inhibition of MDR1 expression in drug-resistant leukemic cells and the resensitization of leukemic cells to anticancer agents.

希望通过逆转录病毒介导的MDR1基因转移从基因水平阻断MDR1基因的转录和翻译，增加肿瘤细胞对化疗药物的敏感性，从而达到杀灭肿瘤细胞的目的。

Methods: Eleven B-CLL patients were studied. Leukemic lymphocytes with (n=8) or without (n=3) P2z receptors were exposed in vitro to ATP, benzoylbenzoic-ATP, 2-methylthio-ATP(2MeSATP), adenosine-5′-［γ-thio］ triphosphate, and other nucleosides for 8h. Apoptosis was detected by electron microscopy, agarose gel electrophoresis, and quantitative TdT assay. Results:Apoptosis was detected only in leukemic lymphocytes with P2z receptors. By using the quantitative assay, ATP-inducing DNA strand breaks were found to occur specifically for BzATP, ATP and 2MeSATP, but not for ATP-γS and other nucleosides.

将表达P2z受体［P2z］与不含P2z受体［P2z］的两组CLL细胞分别同1.0mmol/L三磷酸腺苷体外培养8小时，以电镜、DNA凝胶电泳和定量DNA 3′端TdT法检测细胞凋亡；并对ATP、苯甲酰苯甲酸ATP、2-甲基硫ATP(2MeSATP)、γ-硫代ATP及其它核苷的诱导效应和氧化型ATP、1-［N，O-二(5-异喹啉碘酰基)N-甲基-L-酪氨酰］-4-苯哌嗪KN-62）的抑制效应做定量研究。

The activity of leukemic MLL fusions is believed to be directly contributing to the conversion of normal bone marrow cells into leukemic cancer cells.

目前认为，这种融合引起MLL的激活直接促成了正常骨髓细胞向白血病癌细胞的转变。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。