查询词典 leukemia

ABSTRACT］ Objective To observe the efficacy and side effects of combined therapy with alltrans retinoic acid, arsenic trioxide (As2O3) and chemotherapeutics for newly diagnosed acute promyelocytic leukemia.

急性早幼粒细胞白血病是急性髓系白血病中的一种独特类型(M3型)，以特异的染色体易位t(15，17)(q22，q21)为特征，形成PMLRARa融合基因，该融合基因是APL发病的分子基础和分子标志。

Over the past year, the group evaluated the seven-year follow-up results of therapeutic effects of all-trans retinoic acid and arsenic trioxide (As2O3) combined treatment in newly diagnosed acute promyelocytic leukemia. We also studied the mechanism of therapeutic effects of Imatinib and As4S4 combined treatment in CML cell line and animal model. These two papers were published on PNAS.

过去的一年中，本课题组总结完成了全反式维甲酸和三氧化二砷联合治疗初发急性早幼粒细胞白血病的七年临床随访资料的疗效评估；在慢性粒细胞性白血病，完成了应用As4S4和STI571联合治疗作用的细胞、分子和整体动物水平的机制研究，这两部分工作均已发表于PNAS。

Recently, the arsenic trioxide was found to be an effective drug for leukemia.

最近的研究发现三氧化二砷对於白血病的治疗颇具疗效。

To investigate the mechanism of Arsenic Trioxide treatment to Leukemia.

目的 探讨三氧化二砷(As2O3)治疗白血病的作用机制。

In tomorrow's program, we will introduce the story of leukemia treated with arsenic.

那么在明天的节目时间里我们会向大家介绍砒霜治疗白血病的故事。

Arsenical compounds can inhibit cell growth of leukemia cell at different intensity; this may be correlated with the valency of arsenic and molecular structure of arsenical compounds.

4不同砷剂对细胞作用强弱可能与其结构价态有关。

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

OBJECTIVE: To study the cellular activity of asparagine synthetase in different types of childhood acute lymphoblastic leukemia.

目的：不同类型急性淋巴细胞性白血病对左旋门冬酰胺酶敏感度不完全相同，由于LAsp活性水平与细胞内门冬酰胺合成酶活性负相关，因此研究不同类型ALL患儿白血病细胞内门冬酰胺合成酶活性水平分布情况，有助于临床治疗中合理使用LAsp。

BACKGROUND: Invasive aspergillosis is a leading cause of mortality in patients with acute leukemia.

背景：侵袭性曲霉菌病是导致急性白血病患者死亡的重要原因。

In the present study, the mechanisms of how EGCG enhanced ATO cytotoxicity in leukemia cells were investigated.

结果显示EGCG和三氧化二砷并用可以显著地诱导白血病细胞中过氧化氢和细胞凋亡的发生。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。