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We also found that apoptosis was induced by terfenadine in human cancer cell by DNA laddering formation. In this study,we demonstrated that p21、p27、BAX and BAD protein were induced,in contrast,Bcl-2 protein was down regulated by treated with terfenadine.

经过琼胶电泳分析Terfenadine会使人类癌细胞产生DNA ladder的特徵，表示细胞发生凋亡，并随著剂量的增加我们发现：p21、p27、Bax、Bad表现量上升，而PARP有被切断的片段产生，Bcl-2、Caspase-3减少，而且p27有被切断的情形产生。

We may well explain why ricin-induced apoptosis showed no typical DNA ladder. The presence of laddering in DNA gels implies an apoptosis process, but its absence does not rule out the apoptosis. The ricin 0.05μmol〓 had no effect on the 〓 phase of cell cycle, but induced 〓 arrest. The ricin may affect the balance of synthesis and destruction of proteins that controlling the cell cycle.

检测到DNA梯度表明细胞发生了细胞凋亡，未检测到DNA梯度不能否认凋亡的存在。0.05μmol.L〓的蓖麻毒素对HeLa细胞周期的G〓/G〓期无影响，而诱导了G〓/M期阻滞，蓖麻毒素可能引起一些控制细胞周期蛋白的合成与降解发生紊乱。

The main target of PDT-CPD4 was probably membrance organelles, such as cytomembrance、lysosome、microsome. It made lipide and protein of these membrance dissociate and degenerate, membrance penetration increased. Typical biochemical changes appeared, 180bp bases DNA fragmentation ladder pattern was observed in agar electrophoresis.

但PDT作用后出现线粒体肿胀，可能是因为PDT的主要靶部位是膜性细胞器如线粒体、胞质膜、内质网和溶酶体等，光化学反应产物使这些膜的脂类和蛋白质发生分解变性，膜通透性增高所致。

Since their names were coupled, though, since he was her declared favourite, where was the particular necessity to proclaim it to the rank and file from the housetops, the fact, namely, that he had shared her bedroom which came out in the witnessbox on oath when a thrill went through the packed court literally electrifying everybody in the shape of witnesses swearing to having witnessed him on such and such a particular date in the act of scrambling out of an upstairs apartment with the assistance of a ladder in night apparel, having gained admittance in the same fashion, a fact the weeklies, addicted to the lubric a little, simply coined shoals of money out of.

既然他们二人的名字已经连结在一起，既然她已经公开承认他是她的心上人，还有什么必要从房顶上来向民众宣布呢？这里指的是他和她同床共寝过的事。当这件事在证人席上经过宣誓被公布出来时，座无虚席的法庭上是一片紧张气氛，所有在场的人都为之震动了。证人们宣誓后说，他们曾目睹他在某月某日身穿睡衣靠一把梯子从楼上一间屋子里爬了出来，他是用同一方式爬进去的。此事张扬出去之后，使几家周刊着实发了一笔横财。

Morphologically, the macrophages treated with NO and O-LDL presented shrinkage, nucleus fragmentation, and cytoplasm condensation; DNA ladder was visualized by agarose gel electrophoresis; Characteristic apoptosis peak of macrophages was showed by flow cytometry; Ultrastructure, The chromatin condensed and marginated to form dense chromatin fragmentation; The cytoplasm concentrated and vacuolized; The lysosomes and mitochondria of apoptosis macrophages increased clearly.

电镜观察超微结构变化：染色质固缩边聚，形成致密、均质的染色质块，胞质浓缩、电子密度升高并空泡化；凋亡巨噬细胞溶酶体、线粒体增多；细胞突起缩短减少，但巨噬细胞特有的板状伪足不消失。

These inhibiting social conventions tell us to choose an area of study in college that will produce the most financially rewarding career; they push us to climb the corporate ladder, to earn more money, to buy a bigger house, and to show our love and affection by giving "things;" and these social conventions have us misguiding our children down the same path.

这些起抑制作用的社会惯例总是要求我们去把自己的职业选定在学校里所学过的某个领域，认为这才能够使我们取得最大经济报酬；它们驱使我们去攀登企业和公司的楼体以赚取更多的钱；购买较大的住房，并拿出这些东西来表达我们对配偶的爱情和对子女的慈爱。

The feeble fingers were never idle,and one of her pleasures was to make little things for the school children daily passing to and fro, to drop a pair of mittens from her window for a pair of purple hands, a needlebook for some small mother of many dolls, penwipers for young penmen toiling through forests of pothooks, scrapbooks for picture-loving eyes, and all manner of pleasant devices,till the reluctant climbers of the ladder of learning found their way strewn with flower, as it were, and came to regard the gentle giver as a sort of fairy godmother, who sat above there, and showered down gifts miraculously suited to their tastes and needs.

她那虚弱的手指从未有闲着，她的乐事之一便是为每天从屋旁经过的学童们制作小东西－－在窗口放一双手套，这是为冻紫的手准备的；放个针线包，给某位拥有许多玩具娃娃的小母亲；放一些拭笔布，给那些在歪七竖八的笔划丛林里辛勤劳作的小书法家们；放一些剪贴薄，给那些喜欢画画的孩子们；还有各种各样令人愉快的小玩意，直到那些极不情愿攀登学问阶梯的孩子们发现，他们前进的道路上布满了鲜花。这时他们把那亲切的馈赠者看作是童话中的仙女。她坐在那上边的屋子里，给他们抛投各种奇迹般契合他们品味和需要的礼物。

Results Infected by this peptide, cell viability decreased 28.9%. Under light microscope, cells were shrinked and rounded, many cells were divorced from plate wall, some neuraxon shortened and broke. Apoptotic cells which nucleolus shrinked and rounded could be coloured orange by fluorescent colouration. Under electron microscope, chromatin gathered along the inside of the nuclear membrane, vacuole bodies appeared. Apoptotic peak was detected by flow cytometry and the ladder band appeared in DNA electrophoresis.

结果：细胞接触肽段后存活率下降28.9％；光镜下可见细胞贴壁不良，胞体缩小，细胞突起断裂缩短；荧光染色可见细胞突起缩短、胞核固缩、胞质染成橘红色的凋亡细胞；电镜下可见胞质中出现空泡样结构，细胞染色质浓集于核膜内侧并裂解成碎块状；流式细胞仪检测细胞出现亚二倍体峰，DNA电泳出现梯状带。

Even as he climbed the ladder, Mr. Toyoda said little in top management meetings, according to some nonfamily executives.

据一些外姓经理人说，即使是在丰田章男往上爬的时候，他在高层会议上也是少言寡语。

Even as he climbed the ladder, Mr. Toyoda said little in top management meetings, according to some nonfamily executives.

据一些外姓经理人说，即使是在丰田章男往上爬的时候，他在兴尽兴层会议上也是少言寡语。

This paper discusses design and realizable methods of remote test output interface from logical design angle.

本文从逻辑设计的角度讨论遥测输出接口的设计及实现方法。

This also 星体投射plies to buildings, structures and geological features.

这也适用于建筑物和地质特征。