查询词典 knockdown

Bioassay results at the laboratory showed that HNPC-A2005 had good stomach, contact, comprehensive action and a weak systemic activity to the lepidopterous insects such as oriental armyworm Mythimna separata and imported cabbageworm Pieris rapae. Quick knockdown action was also observed during the experiment.

室内生测结果表明，HNPC-A2005对粘虫和菜青虫等害虫具有优异的胃毒、触杀和综合毒力，且在试验过程中还发现该化合物具有对昆虫击倒快的特点，但内吸作用较弱。

Objective The effect of PKCζ knockdown on the chemotaxis and adhesion ability of human breast cancer cells was investigated.

目的 研究蛋白激酶Cζ降低表达对乳腺癌细胞趋化运动和黏附能力的影响。

Conjunct Will knockdown one of his 2 most threatening targets for 10 seconds.

Conjunct-会击倒两个最有威胁的目标的其中一个，持续时间为10秒。

Although overexpression of Hspa5 does not cause detectable defects, its knockdown by injecting Hspa5 morpholino antisense oligonucleotides results in slower epiboly during gastrulation and dorsalized phenotypes at 24 hpf, including smaller and curled tail and absence of caudal ventral fin. When Hspa5 expresison in embryos is knockdown, the expression of the dorsal markers gsc and ntl is enhanced while the expression of ventral markers is reduced.

尽管在胚胎中过量表达Hspa5对胚胎发育没有明显影响，但是利用反义吗啉环寡核苷酸抑制胚胎中Hspa5的表达会导致胚胎外包变得缓慢，24hpf出现尾部变细或卷曲、缺少腹鳍等背部化的表型，同时gsc和ntl等背部标记基因的表达增强，但eve1等腹部标记基因的表达减弱。

You can get a house for a knockdown price but it may turn out to be a knockdown home.

你可以用极低的价格买到一座房子，但是这作房子可能将是真的一文不值。

Now siRNA has been a strong tool in knockdown of specific gene in mammalian cells.

现在siRNA已经成为knockdown特定基因在哺乳动物细胞系中表达的强大工具。

Furthermore, knockdown of Hspa5 rescues ventralized phenotypes induced by overexpression of Bmp2b; on the other hand, dorsalized phenotypes caused by Hspa5 knockdown disappear when Bmp2b mRNA is coinjected. It is likely that involvement of Hspa5 in dorsoventral patterning is associated with Bmp signals.

进一步研究发现，抑制Hspa5的表达能够挽救Bmp2b过量表达所导致的胚胎腹部化，Bmp2b的过量表达可使阻断Hspa5表达所引起的背部化表型减弱，提示Hspa5在胚胎背腹分化方面的作用可能与Bmp信号相关。

At the one-cell stage, each embryo was injected with gradient doses of 2-8ng MO. The control morpholino, was purchased from Gene-Tools.To test the knockdown effectiveness of the morpholino, the tbx2-EGFP (enhanced green fluorescent protein) construct was generated. And coinjection of morpholino with mRNA tests its specificity of the morpholino. Overexpression of tbx2 via mRNA microinjection helps us understand gaining function of tbx2. Results The tbx2-EGFP construct tests the knockdown effectiveness of the morpholino. Zebrafish embryos lacking tbx2 function have defects in cardiac contractility, rhythm and morphology in a dose-dependent manner. The embryos with c-MO are normal in development. Coinjection of morpholino with mRNA rescue the phenotype of tbx2 knocking down. The phenotypes include pericardial edema, hypogenetic ventricle, dilation of atria, arrhythmia, bradycardia, asystole, abnormal atrioventricular canal, aberrant valve and blood regurgitation.

结果荧光蛋白融合标记实验验证了tbx2-MO可以很好得阻抑斑马鱼胚胎tbx2的表达，tbx2-MO组胚胎在心脏收缩性、节律和形态学发生上出现了异常，心脏畸形随着注射剂量的增加而出现比较一致的表型，而c-MO组胚胎没有出现明显的畸形；tbx2-mRNA和tbx2-MO的共注射减少了tbx2-MO胚胎心脏畸形的发生率及减轻了心脏畸形的程度，验证了所设计合成的tbx2-MO对tbx2基因的抑制作用具有特异性；tbx2-MO组胚胎心脏缺陷包括心室发育不良、心房扩张、房室管和瓣膜异常以及心率缓慢、心律不齐、心脏停搏、血液返流等，并根据心脏发育异常的程度分为轻、中、重度畸形组tbx2-mRNA基因过表达胚胎没有见到心腔的形成。

Methods The net treated by BASF pesticide, the net treated by BASF pesticide after washing twenty times and the net treated by Fendona TM recommended by WHO were used in treated area, and common military nets were selected in the control areas. Aedes vexans, the dominant species in Beiwan, was collected by mosquito aspirators and released into nets. The first knockdown time, medium knockdown time and total knockdown time were recorded, and then compare the knockdown time of 4 kinds of mosquito-net.

研究中选用经BASF药物处理蚊帐、20次洗涤的BASF药物处理蚊帐、5 ml有效成分10%的奋斗呐处理的普通蚊帐，普通军用蚊帐作为对照，在野外环境中用吸蚊器采集当地优势蚊种刺扰伊蚊分别放入4种处理蚊帐中，观察4种处理蚊帐对当地蚊虫的首数击倒、半数击倒、全数击倒时间，最后比较分析4种处理蚊帐对当地主要蚊种的快速击倒效果。

Furthermore, myogenesis was not affected in the FoxD5 morphants, owing to the results of myf5 downergulation in somites and myod upregulation due to the knockdown of myf5, and therefore resulted in myogenin normal expression. In addition, FoxD5 was upregulated in the FoxD3-knockdown embryos, suggesting that FoxD5 might compensate the functions of FoxD3 in the PSM.

进一步观察体节后期分化之肌肉发育，发现在FoxD5 morphants中虽然myf5在体节的表现下降却由表现上升的myod所补偿，因而使得myogenin的表现没有发生变化，显示FoxD5 morphants之肌肉发育没有受到影响；而观察抑制FoxD3的胚胎中，FoxD5在新生成体节中会有表现异位的表现，显示FoxD3在PSM之功能可能由FoxD5来补充。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。