查询词典 knock-on

Somebody break the door. Let Miek out! You, brick man, knock it open!

谁能摧毁这道门放迈克出去就是你石头人把它打开！

It was reported that OP-1 was responsible for the induction of nephrogenic mesenchyme during the development of embryonic kidney. Absence of OP1 would lead to kidney dysplasia. With OP-1 gene knock-out, nude mice died of renal failure within the first 24 hours after birth.

研究发现，OP-1在胚胎肾脏发育期间与肾原性间充质的诱导有关，其缺乏导致肾脏发育不良，OP-1基因敲除突变型的裸鼠在出生后24小时内死于肾功能衰竭。

So far transgenic knockout models of AQP1, AQP3, AQP4 and AQP5, and a knock-in model introducing a point mutation (T126M) that causes autosomal recessive nephrogenic diabetes insipidus in human have been successfully established. Significant progresses have been made in characterizing the physiological functions of these AQPs by systematic mouse phenotype studies.

目前AQP1、3、4、5基因敲除和AQP2基因点突变的基因敲入小鼠模型（模拟人类常染色体隐性遗传尿崩症）已成功建立并广泛用于表型研究，在AQP水通道蛋白生理功能方面获得许多重要进展。

Using lineage marking by direct gfp knock-in andCre-recombinase mediated lineage tracing, we proide eidence that Sox1+ neuroepithelium gies rise to MSCs in part through a neural crest intermediate stage.

借助GFP基因敲入的标记技术和Cre-recombinase 的示踪方法，他们获得相关证据表明部分Sox1+神经上皮在神经嵴发育中期生发了MSC。

METHODS:Antisense "knock-down" approach was used to inhibit MDR1 gene expression in bovine nonpigmented ciliary epithelial cells.

用反义寡核苷酸阻抑牛眼睫状体非色素上皮细胞MDR1基因表达，在激光共聚焦显微镜下检测MDR1基因反

Luciferase assay and CREB knock-down experiments further demonstrate that CREB is involved in the transcriptional upregulation of Noxa.

有意思的是，Mcl-1的蛋白水平也可以通过P13K／Akt信号通路而被CPT上调。

The archetype of the virtuously overbusy person is so ingrained in our societal mind-set that it takes strong language to knock it loose.

在我们社会性思维中，善良而过于忙碌的人这一原型是根深蒂固所以要用强烈的言辞来让它松动。

But when be being searched with Baidu, knock phoneticize directly, with respect to can automatic indication Chinese character.

但用百度搜索时，直接敲入拼音，就会自动显示汉字。

First, endure hardship to build the psychological line of defense: perennial cadres living in poverty in remote areas hard, there should be "located in the poor who do not sorrow," the high Polygalaceae think, to be Director-General, the Director-General can do succeed, not the cause of the Capacity, a "ring for the dark do not have to re-Raymond knock","do not have to Yangbian since Fenti" initiative, a communist party members "to the world to show concern and worry, to enjoy oneself music" psychological motive, a "power is responsibility , Is the leading service, the first to bear hardships, enjoy later,"the sense of public servants.

一是构筑起耐得住艰苦的心理防线：扶贫干部常年生活在艰苦边远地区，就要有&有志不哀地处贫&的高远志想，要有想干事、能干事、干成事、不出事的能力、要有&响鼓不用重锺敲&&不用扬鞭自奋蹄&能动性，要有共产党员&先天下之忧而忧，后天下之乐而乐&心理动机，要有&权力就是责任，领导就是服务、吃苦在前、享受在后&的公仆意识。

MATERIALS AND METHODS: Arg to Ser mutation was introduced into the 249 position of the p53 gene by knock-in method. These ES cells with this mutation were selected according to the homologues-recombination with PCR and Southern blot. The positive ES cells without a selection marker were injected into blastocysts recovered from Hprt(superscript -/-) mice, which were derived from Hprt-deficient ES cells. The injected blastocysts then were implanted into pseudopregnant females.

材料与方法：利用基因打靶技术在小鼠胚胎干细胞p53基因249编码子中引入点突变，使编码子249由精氨酸变成丝氨酸，然后将含突变的ES细胞显微注射到Hprt小鼠囊胚中，将注射过的囊胚植入假孕的雌性小鼠子宫，到第14d取小鼠胚胎纤维母细胞，用含HAT的培养液筛选出从ES细胞分化而成的鼠EF细胞，经测序证实细胞含有由249Arg到Ser的突变。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。