查询词典 knock out

In heat shock protein gp96-peptide complexes induced tumor rejection model,antigen specific CD8T cells adoptively transffered into perforin knock out mice failed to proliferate and differentiate into CTLs whereas co-transfer of wide type NK cells rescued the clonal expansion and CTL differentiation of transferred CDST cells.These results suggested important immuno-modulatory roles of perforin and presumably different roles of perforin secreted by NK cells versus by CD8~+ CTLs.

例如，在热休克蛋白Gp96-肽复合体所诱导的抗肿瘤免疫应答中，穿孔素基因敲除小鼠中单独回输的野生型CD8T细胞不能产生有效的抗肿瘤免疫应答，而同时回输野生型NK细胞能够恢复CTL应答。

For myself, I'm battening the hatches and staying in doors - just praying that the massive amounts of ice and snow hitting the ill-equipped city don't knock out electricity and in turn my only sources of heat, entertainment and work.

我则把自己封在屋子里面，祈祷着这个有着糟糕防备的城市的电力不要被大量的冰雪破坏，否则将会断掉我唯一的暖气来源，以及我的娱乐和工作。

One was the pqsA' positive expression plasmid constructed by cloning the pqsA'-lacZ fusion digested from pYHP441 into miniCTX-1, whose sequence was then integrated into wild type PAO-1 chromosome by biparental mating procedure. The other was pqsA-E operon knock-out plasmid whose sequence between pqsD and pqsE operon was inserted by tetracycline cassette by the site specific insertion mutagenesis strategy and the mutant constructed by biparental mating of S17-1 that harbored the plasmid and pqsA' positive expression mutant.

一种是酶切质粒pYHP441获得pqsA'-lacZ片段后，亚克隆入质粒miniCTX-1中，构建成PqsA'的阳性表达质粒，随后将构建的质粒，通过双亲交配过程整合入野生型铜绿假单胞菌株PAO-1染色体组中；另一种是通过点特异插入诱变策略，将四环素基因盒插入启动子pqsD和pqsE之间，构建的阴性质粒转化入大肠杆菌S17-1株后，和上述pqsA'阳性表达突变株进行双亲交配过程。

Acremonium. However, low frequency of integrative genetic transformation is a major obstacle to gene cloning in Cephalosporium acremonium, for example, screening and identification of genes from a DNA bank by complementation of blocked mutants, knock out or replacement of genes.

过去的一些研究表明质粒对顶头孢霉的转化率太低，限制了许多分子生物学技术的应用，如利用互补突变株从顶头孢霉的DNA文库筛选和鉴别基因、基因敲除或者基因替换。

In.particular, genes involving in histidine biosynthesis (hisJ、 hisG、 hisF、 hisH、 hisB and hisD) were significantly repressed in mutant strain, while other 5 genes such as fur-, ftn-, dps, yecl and bcp which related to iron homeostasis were up-regulated. In addition, after hns gene was knock-out, expression of sjh but not stpA, which encodes H-NS paralogues, increased significantly.

比较特别的是，6个参与组氨酸合成与代谢的基因hisJ、hisG、hisF、hisH、hisB以及hisD在突变体表达下调，而与铁代谢有关的5个基因fur、ftn、dps、yecI和bcp的表达明显上调。

Leif: I came across a beauty today. She is a knock-out.

雷夫：我今天碰上个美女，她美得让人倾倒。

Pentaphyllum is a traditional printed fabric with knock-out version of lessive with printing, commonly known as "" drug anatkina cloth, is about 1,300-year history.

蓝印花布是传统的镂空版白浆防染印花，俗称&药斑布&，距今已有一千三百年历史。

A 1-0 win at Debrecen was not enough to keep Rafa Benitez's men in the competition as Fiorentina beat Olympique Lyonnais to go through to the knock-out phase at the Merseysiders' expense.

1比0击败德布勒森并不足以让贝尼特斯的球队留在欧冠比赛中，由于佛罗伦萨击败了里昂使得其取代默西塞德人进入了淘汰赛。

It was reported that OP-1 was responsible for the induction of nephrogenic mesenchyme during the development of embryonic kidney. Absence of OP1 would lead to kidney dysplasia. With OP-1 gene knock-out, nude mice died of renal failure within the first 24 hours after birth.

研究发现，OP-1在胚胎肾脏发育期间与肾原性间充质的诱导有关，其缺乏导致肾脏发育不良，OP-1基因敲除突变型的裸鼠在出生后24小时内死于肾功能衰竭。

The results showed that in skin trauma and combined radiation-impaired wound models, CGS21680 (agonist of the A2A recaptor) promoted while A2A gene knock-out delayed the course of skin wound healing.

结果表明，CGS21680促进外周组织伤口的愈合，却加重颅脑创伤模型的神经功能损害，这与其促进谷氨酸释放有关。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了