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In clinical. acetylcholinesterase inhibitors reduce the breakdown of synaptic acetylcholine, have been modestly effective in improving the cognitive deficits of Alzheimer's disease.The goal of this work is to determine enzyme kinetics and mechanisms of acetylcholinesterase and butyrlcholinesterase inhibition by five cardiovascular drugs, lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride, and two benzodiazepines, diazepam and chlordiazepoxide hydrochloride. All drugs in this study are reversible mixed-type inhibitors of acetylcholinesterase and butyrylcholinesterase. The pKi values for acetylcholinesterase and butyrylcholinesterase inhibition by the cardiovascular drugs are linearly correlated with the molecular weights of the drugs with the slopes of 0.005 and 0.0021, respectively. Therefore, van der Waals' interactions between acetylcholinesterase and the cardiovascular drugs are stronger than those between butyrylcholinesterase and the drugs. This is probably due to a smaller active site gorge and a more significant peripheral anionic substrate binding site of acetylcholinesterase than those of butyrylcholinesterase.

本研究之目的系决定乙醯胆碱酯酵素和丁醯胆碱酯酵素被五种心脏血管药物lovastatin， simvastatin， amlodipine besylate， nifedipine、hydralazine hydrochloride和两种benzodiazepines：diazepam和Chlordiazepoxide hydrochloride的抑制作用之动力学及机转，这些药物都是乙醯胆碱酯酵素和丁醯胆碱酯酵素的可逆性、混合型之抑制剂，实验结果显示，五种心血管药物对於乙醯胆碱酯酵素及丁醯胆碱酯酵素抑制之pKi值和药物之分子量呈直线之关系，斜率分别为0.005及0.0021因此丁醯胆碱酯酵素，与心血管药物间之凡德瓦作用（van der Waals' ）比乙醯胆碱酯酵素与心血管药物间者弱，这可能原因是丁醯胆碱酯酵素之活性区域比乙醯胆碱酯酵素之活性区域更宽广，但丁醯胆碱酯酵素之周边阴离子区域不及乙醯胆碱酯酵素之周边阴离子区域者明显重要，由於五种心血管药物对於乙醯胆碱酯酵素和丁醯胆碱酯酵素抑制之pKi值存在著线性关系表示此种抑制作用系经过共同之反应机理。

Using the diffusion coefficient obtained from the 400mg/L chlorophenol experiments, the model was able to predict the sorption kinetics of chlorophenol onto soil at different concentrations, indicating that the model is appropriate for describing the transport of phenol and chlorophenol within the two soils.

其中，第一种模式系假设土壤颗粒大小在实验过程中并不会随时间改变，计算求得之孔隙扩散系数约在8.3*10/sup -8/cm/sup 2//sec至2.9* 10/sup -7/cm/sup 2//sec附近，曲折度约为33-125，虽然曲折度和文献值相近，但因粒径不随时间变化的假设与实验所观察到的结果不符，所以此部分的结果较不具合理性。

AIM: To establish an animal model of cholesterol stone and to explore the effects of cholecystokinin on gallbladder muscle stripes of guinea pigs with cholesterol stone in vitro as well as to investigate the role of biliary kinetics in cholesterol stone formation.

摘要目的：建立胆固醇结石实验动物模型，探讨胆囊收缩素(cholecystokinin， CCK)对胆固醇结石豚鼠离体胆囊肌条收缩的影响，并研究胆道动力因素在胆固醇结石形成中的作用。

In this work the bleaching kinetics of bamboo SCMP in peroxide were investigated,and the elimination mechanism of its chromophore was also discussed.

本文研究了竹子磺化化机浆在 H_2O_2漂白时的反应动力学，并就其发色基团的脱除机理进行了探讨。

The kinetics of chrysotile in hydrochloric acid is studied by building the overall kinetic model for the fibrous particle in liquid-solid reaction.

进而通过建立液－固相反应纤维状颗粒的宏观动力学模型，研究了纤蛇纹石盐酸浸出的动力学过程。

The aims of this study were:(1) to find methods to analyze 7-tocopherol and its metabolites;(2) to study the kinetics of 7-tocopherol metabolized in the S9 of male SD-rat liver in vitro;(3) to compare the differences of 7-tocopherol metabolized in the liver S9 of male SD-rat, male Brazil turtle and male cobia, respectively.

研究内容主要是：(1)γ-生育酚代谢物的分析方法；(2)γ-生育酚在雄性SD-大鼠肝S9的体外代谢动力学；(3)比较γ-生育酚在不同代谢水平动物的肝S9中代谢的差异。

The dissolution kinetics of colemanite was examined according to heterogeneous and homogeneous reaction models.

硬硼酸钙的溶解动力学根据多相和均相反应模型进行了检验。

The curriculum mainly introduces the fundamental principle and research technique on chemical thermodynamics, chemical kinetics, electrochemistry, surface chemistry and colloid chemistry and so on.

本课程主要介绍化学热力学、化学动力学、电化学、表面化学、胶体等基本原理知识和研究方法。

Of Pharmacy course, students can grasp the physical chemistry of chemical thermodynamics, chemical kinetics, interface and colloid chemistry basic theories and knowledge to be applied in pharmaceutical research. Meanwhile the students lay a good foundation.

此课程结合药学专业的特点，为培养学生能将物理化学中有关化学热力学、化学动力学、界面及胶体化学等基本理论和知识，较好地应用于药学专业研究，奠定了良好的基础。

Curing kinetics for two kinds of isomeric compound different proportion BPF-epoxy resin/MeTHPA/DMP-30 system is studied by means of differential scanning calorimetryand the extreme value method.

利用差示扫描量热法和极值法对两种同分异构体分布不同的双酚F环氧树脂/甲基四氢苯酐/DMP-30体系固化动力学进行了研究，求得了体系的固化动力学参数，并对同分异构体分布与固化特性之间的关系进行了初步讨论。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。