查询词典 kinases

Objective To study the effects of transfection of tyrosine kinases on the tumorigenesis of nasopharyngeal carcinoma.

目的：研究酪氨酸激酶转染对鼻咽癌细胞成瘤的影响。

Protein tyrosine kinases play an important role in signal transduction pathways in regulating a number of cellular functions.

蛋白质酪氨酸在一系列细胞活动的信号转导途径中起著重要的作用。

Tyrosine protein kinase is one of the key kinases in cell signal transduction,which plays an important role in cell growth,development and functional regulation.

酪氨酸蛋白激酶是细胞信号转导的主要信号酶之一，对细胞的生长、发育与功能调控起着重要的作用。

Among them, the promoter region hypermethylation of cyclin-dependent kinases inhibitors are confined play an important role in cell cycle uncontrol and in CRC carcinogenesis.

近年来普遍认为DNA甲基化与肿瘤抑制基因包括错配修复基因、血管生成抑制基因、细胞粘附分子相关基因的失活有关，是肿瘤发生的第三种机制。

A new type of Ca~(2+) sensors unique to higher plants have been studied recently, they are the so-called CBLs for their similarity to B-subunit of yeast and animal calcineurin. Plant CBLs interact with and regulate the activity of a group of Ser/Thr protein kinases, referred to as CIPKs .

在高等植物体内存在一类类似于酵母和动物体内钙调磷酸酶B的蛋白，简称CBL，它的靶蛋白是一类具有丝氨酸/苏氨酸激酶活性的蛋白，被称为CIPK(CBL-interacting protein kinase)。

Accordingly, the researchers have proved that these checkpoint kinases also exist alongside the centrosome and perform their function there.

由此，科学家们证实这些检测点激酶同样存在于细胞中心体附近，并发挥着他们的作用。

These findings suggest that Coriandrum sativum L. through modulating NF-kB activation and mitogen-activated protein kinases signal transduction pathway suppresses the inflammatory responses in LPS-induced RAW264.7 macrophage cells.

综合以上结果得知：香菜可经由抑制LPS诱发转录因子NF-κB活化及MAPK讯息传递路径，减少促发炎因子生成而具抗发炎之功效。

AIM: To investigate the change of cell cycle checkpoint kinases Chk1/2 in human gastric cancer MGC803 cells induced by diallyl disulfide. METHODS: mRNA expression was assayed by means of RT-PCR in MGC803 cells treated with DADS.

目的：观察二烯丙基二硫化物对人胃癌MGC803细胞的细胞周期检查点激酶1(Chk1)和细胞周期检查点激酶2(Chk2)的影响。

Other aspects will look at engineering mitotic kinases and translational opportunities for human health.

该项目还将涉及到有丝分裂激酶和人类健康等方面的研究。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

I think people in this lifetime in a rebirth.

我觉得人在这一生里其实也在轮回。

He had to tie her hands together.

他不得不把她的双手绑在一起。