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Results Acute oral LD50 were 278 mg/kg and 56.2 mg/kg in rats and mice respectively, while dermal LD50＞2 000 mg/kg and inhalative LC50＞3 000 mg/m3. Skin and eye irritancy were estimated to be negative and mild respectively. Cumulative coefficient was 2.3 and allergic rate was 0%. A negative result was observed in Ames assay while increased frequencies of bone marrow micronuclei and spermatocyte chromosome aberrations were noted in the high dose (11.24 mg/kg) group.

结果 大小鼠急性LD50分别为278 mg/kg和56.2 mg/kg；大鼠经皮LD50＞2 000 mg/kg；急性吸入LC50＞3 000 mg/m3；无皮肤刺激性，轻度眼刺激性；蓄积系数2.3；致敏率为0；Ames试验结果阴性；微核和染色体在高剂量组(11.24 mg/kg)与阴性对照组相比有高度显著性差异(P＜0.01)；大鼠90天亚慢性经口的最大无作用剂量为2.825 mg/kg。

In adriamycin group, adriamycin 1mg/kg was injected abdominally on the 2nd and 4th days after experiment, 2 mg/kg was injected on the 6th and 8th days, 3 mg/kg was on the 10th and 12th days and 4 mg/kg was on the 14th and 16th days.

阿霉素组：于实验开始后第2，4天腹腔注射阿霉素1 mg/kg；第6，8天腹腔注射2 mg/kg；第10，12天腹腔注射3 mg/kg；第14，16天腹腔注射4 mg/kg，16 d累计用药量达20 mg/kg。

Based on this,We designed a series of experiments to study the treatment and its mechanism of Iridoids composition of Valeriana jatamansi Jones of the IBS animal model.1 Research on Iridoids composition of Valeriana jatamansi Jones in the role of gastrointestinal function.1.1 Effection of Iridoids composition of Valeriana jatamansi Jones on gastrointestinal function of normal miceMethods:Compared with normal group and YJBH group,mice which has given Iridoids composition of Valeriana jatamansi Jones as 71.2mg/kg,35.6mg/kg,17.8mg/kg,8.9mg/kg was detected gastric emptying and small intestinal propulsion after 4 days drug given.Results:Compared with normal group,gastric emptying and small intestinal propulsion in 35.6mg/kg and 17.8mg/kg group was inhibited.

课题通过观察蜘蛛香环烯醚萜对正常及IBS模型动物的胃肠道功能、精神活动的影响，以及蜘蛛香环烯醚萜干预下IBS大鼠结肠、血清、中枢5-HT含量，结肠5-HTR3A受体的mRNA和色氨酸羟化酶(TPH1)的mRNA表达，结肠和血浆中SP和VIP含量以及结肠中肥大细胞分布，探讨蜘蛛香环烯醚萜对腹泻型IBS的治疗作用及其作用机理，为临床治疗IBS提供实验依据。1蜘蛛香环烯醚萜对胃肠功能的作用目的：探讨蜘蛛香环烯醚萜对胃肠功能的影响1.1蜘蛛香环烯醚萜对正常小鼠胃肠功能的作用方法：正常小鼠灌胃给予蜘蛛香环烯醚萜71.2mg/kg、35.6mg/kg、17.8mg/kg、8.9mg/kg与空白组和越鞠保和丸组对照，给药4日后测定动物的胃排空率和小肠推进率。

Methods Ninety ASA Ⅰ~Ⅱ patients undergoing UPPP surgery were randomly divided into three groups: F group (fentanyl 10 μg/kg), FL group (fentanyl 5 μg/kg + lornoxicam 0.4 mg/kg), or TL group (tramadol 5 mg/kg + lornoxicam 0.4 mg/kg). The drugs were diluted with normal saline to 100 mL (background 2 mL/h, PCIA bolos 1.5 mL, lockout time 15 min).

90例择期行UPPP的阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea， syndrome， OSAS，即鼾症）患者，ASAⅠ~Ⅱ级，随机分为3组(n=30)，F组：芬太尼10μg/kg；FL组：芬太尼5μg/kg+氯诺昔康0.4mg/kg；TL组：曲马多5mg/kg+氯诺昔康0.4mg/kg；每组镇吐药物均为氟哌啶5mg，均以生理盐水稀释至100mL，背景剂量2mL/h，PCIA1.5 mL/次，锁定时间15min。

Injection of rhIL-2 (200,100,50,25,12. 5 ku/kg) can inhibit mouse ear swelling, especially when dosage is 25～50 ku/kg. Injection of rhIL-2 (25 ku/kg) can inhibit rat plantar swelling. The function of mononuclear macrophage system was strengthened by hypodermic injection of rhIL-2( 100 ku/kg) once a day for 9 days. The decrease of mouse delayed-type hypersensitivity reaction induced by cyclophosphamide was extenuated by hypodermic injection of rhIL-2(50 ku/kg) once a day for 6 days. IL-2 has anti-inflammatory effects and immunomodulatory effects when administered in certain dosage.

RhIL-2注射液，剂量为20，10，5，2.5，1.25万u/kg时，对小鼠鼠耳肿胀模型有抑制作用，其中剂量为2.5～5万u/kg时，抑制率最大；剂量为2.5万u/kg时，对大鼠足拓肿胀模型有显著的抑制作用；rhIL-2注射液每日sc用药剂量为10万u/kg，连续给药9d后，可以明显增强小鼠单核吞噬细胞功能；rhIL-2注射液每日sc用药剂量为5万u/kg，连续给药6d后，可明显减轻由免疫抑制剂引起的小鼠迟发性变态反应降低的强度。rhIL-2在一定剂量范围内可以起到抗炎和免疫调节作用。

Author was menstruated content of boron and researched the status of lack of Boron and researched relativity of its Influencing facto, the results showed that the average content of available boron in the yellow soil was 0.39±0.27 mg/kg, 80 percent of its was under 0.5mg/kg which was lack for boron and 17.44 percent of its was under 0.2mg/kg which was especially lack for boron; The distribute frequencies of available boron contents of yellow soils in Chongqing was dispersedly, its range of 0.07mg/kg to 1.99mg/kg. The diversity of different zoology area was distinct. The result of pertinence analyses showed that available boron contents had correlativity with the pH(r=0.181** n=281) and CEC（r=0.124** n=281 and It had correlativity with Organic matte When the content of organic matte is high; in addition, soil granule、clime was the Influencing factor of availability of boron in Yellow Soils in Chongqing.

笔者通过调查取样对重庆市黄壤硼的含量进行测定并分析了缺硼的程度，对其影响因素进行了相关性分析，研究结果表明：重庆市黄壤有效硼的平均含量为0.39±0.27mg/kg，其中近80%的土壤样品有效硼含量低于0.5mg/kg，属于低硼或缺硼土壤，还有17.44%的土壤样品有效硼含量低于0.2mg/kg，属于极度缺硼的土壤；而有效硼含量的分布频率比较分散，变幅较大，从0.07mg/kg~1.99mg/kg，变异系数达到69.41%，不同生态类型区土壤有效硼含量的差异十分明显；而相关性分析结果表明：土壤有效硼与土壤pH值(r=0.181** n=281)和CEC（r=0.124** n=281呈正相关，在有机质含量较高的条件下与其相关性也较为显著（r=0.347** n=90，而土壤质地以及气候也对重庆市黄壤硼的有效性有很大的影响

Randomized block design with single factor was adopted in the experiment.The energy level of group Ⅲ(with digestive energy of 12.98 MJ/kg) was designed according to the feeding standard energy requirement of Chinese meat-fat type of growth-finishing pigs,while the energy level of groupⅠ(with digestive energy of 14.22 MJ/kg) was designed according to feeding standard of NRC(1998) growth-finishing pigs.The energy level of group Ⅱ(with digestive energy of 13.60 MJ/kg) was designed between groupⅠ and Ⅲ.The energy levels of group Ⅳ and Ⅴ were designed under the energy level of group Ⅲ.The gradient of each adjacent energy level was 0.62 MJ/kg.

试验采用单因子随机分组设计，以中国肉脂型生长肥育猪饲养标准能量需要设计中能量水平(组Ⅲ，消化能12.98MJ/kg)，以NRC(1998)生长肥育猪饲养标准能量需要设计最高能量水平(组Ⅰ，消化能14.22 MJ/kg)，此两个能量水平间设计中高能量水平(组Ⅱ，消化能13.60MJ/kg)，在中能量水平下依次分别设计中低能量水平(组Ⅳ，消化能12.36MJ/kg)和最低能量水平(组Ⅴ，消化能11.74MJ/kg)，每个能量水平间的梯度为0.62MJ/kg。

The results showed that GP (320 mg/kg) combined with ADM (2 mg/kg) could significantly prolong survival Lime of mice bearing SF763 tumor, the life-prolonging rate was 88%(P40 mg/kg) significantly had a inhibition no A549 (P.05), the optium dosage of GP was 80 mg/kg, which had an inhibition of 82.2%(P.01) after an inoculation of 11 days; GP had a negative relation on prolonging survival time of mice bearing EC tumors between dosage of GP and the effect. The optimum dosage was 5-10 mg/kg, which had optimum prolonging rate of 32.77%(P.05). Thus GP could significantly prolong survival time of mice bearing SF763, A549 and EC tumors.

结果表明：生药剂量320 mg/kg GP联合2 mg/kg阿霉素，其生命延长率为88%(P01)，GP能明显延长荷人脑瘤SF763裸鼠生命；GP在大于40 mg/kg时对人肺腺瘤A549裸鼠具有明显的抑制作用(P.05)，最佳剂量为GP 80 mg/kg，接种时间11d，抑瘤率为82.2%(P.01)；GP对艾氏腹水瘤EC小鼠的生存期呈现负量效关系，GP最佳剂量范围在5~10 mg/kg，最高生命延长率为32.77%(P.05)。

The average value of the total nitrogen,ammonium nitrogen,nitrate nitrogen,available nitrogen and organic nitrogen were 4591 mg/kg,12.66 mg/kg,1.8 mg/kg,26.25 mg/kg and 4598 mg/kg respectively.The forms of nitrogen that we concerned were decreased from plow layer to subsoil in five paddy soil profile.

土壤表层全氮、铵态氮(NH_4~-N)、硝态氮(NO_3~--N)、碱解氮、有机氮均匀含量分别为4591 mg/kg、12.66 mg/kg、1.8 mg/kg、26.25 mg/kg、4598 mg/kg，土壤表层各形态氮素的含量在剖面中的分布特征是从表层到底层呈下降趋势。

The results showed that the fluorine concentration in water, soil, fuel, food vegetable,butter tea and Zanba both of them were made from brick teas was 0.06 mg·L -1 , 0.45mg·kg -1 , 0.10mg·kg -1 ,0.06～0.33mg·kg -1 ,3.09mg·L -1 and 3.61mg·kg -1 ,respectively. The water soluble fluorine content in brick tea which came from Sichuan and Yunnan Provinces reached up to 533.89～617.32 mg·kg -1 . It is suggested that drinking brick tea may induce fluorosis in Tibetan habitats.

西藏的水F含量均数为0.06mg·L-1，土壤可溶性F 0.45mg·kg-1，主要燃料F含量0.10mg·kg-1，主要粮食、食品以及蔬菜的F含量0.06～0.33mg·kg-1，用砖茶调制的酥油茶和糌粑F含量达3.09mg·L-1和3.61mg·kg-1，产自四川、云南的砖茶水溶性F含量达到53 3.89～617.32mg·kg-1，可以认为，西藏有可能是砖茶型F中毒的流行区。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。