查询词典 keloid

Objective To explore the effect of connective tissue growth factor on the pathogenesis of hypertrophic scar and keloid tissue.

目的探讨结缔组织生长因子在增生性瘢痕和瘢痕疙瘩发病机制中的作用。

Results Compared to those before treatment the volume of the implanted keloid of Group D began to decrease since 14 days after treatment time-dependently (all P 《 0.05), and the volumes of the other 3 groups continued to increase and peaked on days 21, 14, or 7 respectively (all P 《 0.05).Microscopy showed infiltration of a larger quantity of histiocyte in the keloid tissue, and more obvious collagen disorganization and apoptosis of fibroblasts in Group D than in the other 3 groups.The protein expression of Bcl-2 was more remarkable and the protein expression of BAX was less remarkable in Group D than iu the other 3 groups.

结果 用药前和用药后7、14、21、28、35 d，D组瘢痕疙瘩组织块体积(mm3)分别为173±5、172±5、147±5、125±6、112±7和84±9，从用药后14 d开始明显缩小(均P＜0.05)；而其他3组瘢痕疙瘩组织块体积均明显增大，从用约后7 d开始各时点测得的体积均明显大于D组(均P＜0.05)。D组瘢痕疙瘩组织中有大量小鼠组织细胞浸润，胶原结构破坏和成纤维细胞凋亡明显重于其他3组，Bcl-2蛋门质表达明显弱于而Bax蛋白质表达明显强于其他3组。

RESULTS: These familial keloids mainly occurred during adolescence, showing the equal chance of being affected between male and female subjects. The affected person could be heterozygous, and a child of an affected parent had a 50% chance of being affected. Thirteen subjects displayed familiar keloid, 1 suspected keloid, 2 did not present keloid as obligate carriers, and 1 did not present keloid as doubtful carrier. One pedigree displayed keloid in 3 generations, two displayed in 2 generations. The traits of familial keloids were transmitted interruptedly, revealing incomplete penetrance. The clinical phenotypes of familial keloids presented variable expression among the different affected.

结果：这些瘢痕疙瘩家系以青春期发病为主，男女患病的机会均等；杂合体即可发病，双亲之一发病其半数子女可能发病；3个瘢痕疙瘩家系发病13人，可疑发病1人，2个未发病肯定携带者，1个未发病可疑携带者；3代发病家系1个，2代发病家系2个；瘢痕疙瘩性状存在间断传递、外显不完全现象；临床表型存在个体差异。

This could be a sign that a thick scar or keloid is forming.

这可能是告示一道厚的疤痕或者 keloid 正在形成。

Results The percentage of special diathesis type increased in the group with positive family history of keloid. The percentage of wet-heat or blood-stasis and special diathesis type increased respectively in the group with keloid on the chest and submaxilla area or on the limbs; The percentage of wet-heat type increased in the group with conspicuous inflamed keloid; The percentage of wet-heat or phlegm-wetness type increased respectively in the group with acne correlated keloid or acne uncorrelated keloid.

结果：瘢痕疙瘩有家族史者偏颇为特禀质的百分比增加；胸部、下颌部受累者偏颇为湿热质的百分比增加，四肢部受累者偏颇为瘀血质、特禀质的百分比增加；炎症明显者偏颇为湿热质的百分比增加；与痤疮相关者偏颇为湿热质的百分比增加，与痤疮不相关者偏颇为痰湿质的百分比增加。

Results:The positive rates of TSP- 1 mRNA in hypertrophic scars and keloid were lower than those in normal skin and surgical scar. MVC was higher in the cases with negative expression of TSP - 1 mRNA than the ones with positive expression of TSP - 1 mRNA. MVC was higher in the hyperstrophic scar and keloid than in normal skin and surgical scar.

结果TSP-1 mRNA在增生性瘢痕和瘢痕疙瘩中表达的阳性率低于在正常皮肤和外科瘢痕组织中的表达(P＜0.05)；TSP-1 mRNA表达阴性病例组的MVC显著高于TSP-1 mRNA阳性病例组的MCV(P＜0.05)；增生性瘢痕和瘢痕疙瘩组织中微血管数多于正常皮肤和外科瘢痕组织的微血管。

The Nuer and Nuba use lip plugs, keloid tattoos along the forehead, keloid tattoos along the chin and above the lip, and cornrows.

沿着前额或者下巴或者在嘴唇上。

the fibroblasts are activated in collagen synthesis in active keloid. The enhanced collagen synthesis by fibroblasts is a critical factor leading to the overabundant collagen accumulation in keloid.

结论在活跃增生的瘢痕疙瘩中，成纤维细胞胶原合成功能处于活化状态，胶原合成增加是瘢痕疙瘩中胶原过度积聚的重要原因。

Materials and Methods: From January 2005 to December 2006, patients diagnosed with keloid were selected to receive six doses of pulsed dye laser therapy. Clinical assessments were evaluated before and 1 month after the laser therapy. Keloid tissue samples were also collected before and 1 month after laser therapy. Laboratory analysis included immunohistochemical staining of TGF-β and phosphorylated Smad2, and real-time PCR of Smad2 mRNA.

材料与方法：在西元2005年至2006年间，10个有keloid的病人在签署同意书之后，接受6次染料雷射的治疗，在雷射治疗前以及之后一个月，接受临床表现的评估和部分keloid组织切除，执行TGF-β和Smad2蛋白的免疫染色分析，和Smad2的mRNA定量分析。

Background and Objectives: Keloid is benign hyperproliferative collagen formation in response to skin trauma. Although the pathoetiology of keloid formation remains unclear, over reaction of the TGF-β pathway is believed to be a mechanism. In this study, we survey the differences in clinical presentation and the change in molecules of the TGF-β pathway after pulsed dye laser therapy.

背景及目的： Keloid组织除在临床上造成外观问题，也有痛或痒的困扰，但是及造成原因并不明确，很多研究指出和TGF-β路径有相关性，临床上治疗方式有很多种，染料雷射是其中之一，在临床治疗提供显著的改善，所以研究对於TGF-β路径其中分子的影响，及其可能的机转为何。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。