查询词典 kail

Kail gene,cloned in 1995,has been approved to related to the progress of many kinds of neoplasms.

Kai1基因在这一过程中起抑制作用。

Tis because there's a new hand come among us,' said Jonathan Kail.

"这是因为我们中间来了一个新人，"约纳森。

According to the specialty of the structure,it may be predicted that the function of Kail gene come down to cell-cell adherence and cell-matrix connection.

结构分析提示它在细胞与细胞间粘附、细胞与基质的连接中可能起有一定作用，研究也证实它可以增强肿瘤细胞之间的聚集能力，降低其吞噬能力及侵袭能力，而不影响细胞的增殖力。

Tis because theres a new hand come among us, said Jonathan Kail.

"这是因为我们中间来了一个新人，"约纳森。

The results showed that mutation of the Kail gene,methylation of CpG islands and the abnormity of p53 are not related to low expression of Kail.

实验结果表明：基因点突变、启动子CpG岛甲基化、p53蛋白异常与Kai1基因表达下调不存在相关性。

Previous studies also showed that the Kail contributed to increasing the carcinoma cells aggregation,decreasing the phagokinetic activity and invasive ability,but no influence of the cell proliferation.

目前研究证实Kai1／CD82对多种肿瘤转移具有抑制作用，但其与大肠癌转移相关性的研究尚不多，特别是其表达下调的机制未有报道。

Conjuror Fall, t'other side of Casterbridge that they used to call "Wide-O", was a very good man when I was a boy,' said Jonathan Kail.

"在我小的时候，卡斯特桥那边住着个魔术师，名叫福尔①，大家习惯叫他'大圆圈'，他倒是一个道行高的人，"约纳森。

Although many efforts have been made to elucidate the role of Kail gene in many kinds of carcinoma,there are little reports concerning the role of Kail in human colorectal carcinoma,especially regarding the mechanism of its down-regulation in metastasis carcinoma. In present study,the expression of Kail was detected by in situ hybridization,immumohistochemistry and Western Blot in four cell lines of HCC with different metastatic potential.

为探讨Kai1基因与大肠癌转移之间的相关性，本研究利用四种不同转移潜能的大肠癌细胞系HCT116、HT29、LoVo与SW480，从mRNA与蛋白质水平，用原位核酸杂交、免疫组织化学与Western Blot三种方法检测Kai1／CD82的表达，得到了一致的结果：Kai1／CD82在HT29与SW480细胞系的表达较LoVo与HCT116为高。

In conclusion,this research has gotten some significant results:firstly Kail gene is highly related with the metastasis potential of colorectal carcinoma cells,secondly mutation of Kail gene,methylation of CpG islands in the promoter and abnormal expression of p53 have no important effects in the down-regulation of Kail gene.

本研究结果表明：Kai1基因与大肠癌细胞转移潜能有关；基因点突变、启动子CpG岛甲基化与p53异常在Kai1基因表达下调中不起重要作用。

The results indicated that Kail/CD82 is higher expressed in HT29 and SW480 than in LoVo and HCT116 whatever in mRNA or protein level.The possible mechanism of down regulation of Kail was also analyzed. By PCR-SSCP,8 exons of Kail,exon 3 to exon 10,were screened in LoVo and HCT116 cell lines. The methylation of CpG islands in promoter region was analyzed,and the expression level of p53 was detected by IH and Western Blot.

为进一步探讨Kai1基因表达下调的机制，本研究用PCR-SSCP技术分析了Kai1／CD82表达较低的LoVo与HCT116细胞系的Kai1基因第3～10外显子是否存在点突变，检测Kai1基因启动子区域CpG岛的甲基化状况，并用免疫组化与Western Blot等方法研究Kai1基因表达与p53异常之间的相关性。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失