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The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.
结果:1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长,同时促进细胞的分化和凋亡:白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化,UW228-3、Med-3细胞向神经元细胞方向成熟分化,以100μM作用48小时效果显著;2、四个细胞系均有Fas和Caspase-3表达,但无Fas-L基因表达和蛋白活性产生,因此难以形成Fas相关性死亡通路;3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同:UW228-1,-2,-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达,而Med-3细胞系,白藜芦醇却抑制CYP1A1的表达;四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制;4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变,表现在G0/G1期在整个细胞周期中所占的比例增加,而其它时期则相应减少。
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All relation s of production and superstructures, irrespective of their nature, develop with the development of productive forces.
无论什么样的生产关系和上层建筑,都要随着生产力的发展而发展。
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Technical bid tabulations for all equipment irrespective of value shall be submitted for PMC's review prior to CONTRACTOR's award of a purchase order.
在不涉及价值的条件下,所有设备的技术标书内容都要在承包商正式订单签约之前提交给PMC方面审查。
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She did this irrespective of whether they were Nobel-prize winners or world leader such as Chou En-Lai or Deng Xiao-Ping.
无论他们是诺贝尔奖获得者还是世界闻名的领导人,比如周恩来或者邓小平。
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So Drossart made another dazzling offer: 'I want you to be aware of the fact that IMG/UFA are prepared to offer the most attractive bid to FIFA for the World Cup 2002 commercial rights, irrespective of alternative proposals.
于是德罗萨特提出另一个令人瞠目结舌的报价:&我想让你们知道,不论其他投标者出价如何,IMG/UFA都准备为2002年世界杯的商业权益提出最有吸引力的报价。&
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So Drossart made another dazzling offer: 'I want you to be aware of the fact that IMG/UFA are prepared to offer the most attractive bid to FIFA for the World Cup 2002 commercial rights, irrespective of alternative proposals.
于是德罗萨尔提出另一个令人瞠目结舌的报价:&我想让你们知道,不论其他投标者出价如何,IMG/UFA都准备为2002年世界杯的商业权提出最有吸引力的报价。&
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FROM BENEFICIARYS WAREHOUSE TO APPLICANTS WAREHOUSE IN COIMBATORE COVERING TRANSPORTATION BY RAIL/ROAD WITH ClAIM PAYABLE IN INDIA ,IRRESPECTIVE OF PERCENTAGE CLAUSE.
请问IN COIMBATORE后的英文是说包括铁路和公路运输都是在印度索赔是吗?逗号后面的英文是什么意思?
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FCA term may be used irrespective of the mode of transport, including multimodal transport.
FCA术语可用于各种运输方式,包括多式联运。
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Irrespective of nationality, education, linguistic skills or faith, the universal warmth of the people I'd met on the Rossiya made the journey unique.
与人们的国籍、教育、语言或信仰无关,使我的旅程变得独一无二的,是我在罗西娅号上感受到的普世的人性温暖。
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Also, for all the holy beings of the world, irrespective of sects, for the swift coming of H.H.
毫无宗教之别地,我们也要为全世界所有的圣者作祈愿。
- 推荐网络例句
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Plunder melds and run with this jewel!
掠夺melds和运行与此宝石!
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My dream is to be a crazy growing tree and extend at the edge between the city and the forest.
此刻,也许正是在通往天国的路上,我体验着这白色的晕旋。
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When you click Save, you save the file to the host′s hard disk or server, not to your own machine.
单击"保存"会将文件保存到主持人的硬盘或服务器上,而不是您自己的计算机上。