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The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果:1合成的CS-PAA磁性聚合物微球呈球形,大小均一,TEM测定其干态下粒径为80nm左右,磁化曲线证实具有超顺磁性,具有一定的PH敏感性,固载表柔比星后,水溶液性状稳定,无沉淀物,DLS测定直径约200nm左右,测定载药率为15%,较文献报道高,包封率为20%。2肉眼观察试验组大鼠膀胱表面呈褐色,可见大量的Fe粒子聚集,普鲁士兰染色法显示,试验组大鼠膀胱壁内有大量的Fe粒子,分布至膀胱壁全层,与对照组大鼠相比,试验组大鼠的肝、脾内的Fe粒子聚集量明显降低;HPLC测定结果与Fe染色相同;高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高,其他组大鼠血生化指标没有明显变化。3MTT法发现,高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组,FCM发现试验药物组可引起明显的肿瘤细胞凋亡,试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C,试验组细胞Bcl-2蛋白减少,Bax蛋白变化不明显,Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P<0.01),其中高剂量组的抑制率最高。

In mammals, iron balance is maintained by meticulous regulation of iron absorption from the duodenum, which responds to body iron stores and erythropoietic iron demand.

动物体内铁的恒定受到小肠细胞的严密调控,小肠对铁的吸收能力与体内铁贮存量与造血组织需求量有关。

Structure and corrosion behavior of the high silicon cast iron in several different environments have been tested by means of weight-loss analysis and metallograph,and compare the corrosion resistant of high silicon cast iron with common gray iron and white iron.

采用失重分析、金相分析等试验方法研究了高硅铸铁在不同环境下的耐腐蚀性能,并对高硅铸铁、普通灰铸铁及白口铸铁的耐腐蚀性进行比较。

One of the potential advantages of the hypoxia-induced factor prolyl hydroxylase inhibitor approach to anemia therapy over ESA is improved regulation of iron absorption and iron recycling to improve the efficiency of iron utilization, partially via a mechanism of hepcidin suppression, to overcome functional iron deficiency.

用作贫血治疗的缺氧诱导因子脯氨酰羟基化酶抑制剂相对于红细胞生成作用刺激剂的一个优势是铁吸收和铁再利用的调节得到改善,提高了铁利用的效率,尤其是通过铁调节蛋白抑制机制,克服功能性铁缺乏。

According to the property of mud of gas of plum steel blast furnace, undertook to its zincic experiment studies receiving iron to fall, no matter use magnetic separation,the result makes clear or classification the law all can reclaim from which content of major iron ore and purify is major zinc, stock of will tall zinc, low zinc undertakes effective depart, iron concentrate yield and grade all achieve 52% above, iron metal reclaims rate 70%, take off zinc to lead 50% above.

梗概: 介绍了梅钢高炉瓦斯泥的性质、试验情况及结果,国内外处理使用含锌高炉瓦斯泥的方法。根据梅钢高炉瓦斯泥的性质,对其进行了收铁降锌的试验探究,结果表明无论用磁选还是分级法均能从中回收大部分铁矿物并去除大部分锌,将高锌、低锌物料进行有效分离,铁精矿产率和品位均达到52%以上,铁金属回收率70%,脱锌率50%以上。

The treating process of blowing O_2、 N_2 Ar into molten cast iron and the dynamics and thermodynamics of the blowing process are studied. The effects of gas composite, blowing intensity, blowing form and molten iron temperature on molten iron composition and casting quality are analysed. And molten pig iron of the blast furnace is blown in 3t ladle.

用O_2、N_2、Ar气体对铁水进行吹炼处理,分析了吹炼处理的热力学与动力学原理,研究了吹炼处理的气体组成、吹气强度、吹气方式以及铁水温度对铁水成分与铸件质量的影响,并在3t铁水包中对高炉铁水直接进行吹炼处理。

Iron oxide pigment is a color pigment whose basic substance is the oxide of iron,such as red oxide, yellow iron oxide, black iron oxide, and brown oxide.

氧化铁颜料主要指基本物质为铁的氧化物的着色颜料,如氧化铁红、铁黑、铁黄、铁棕等。

And iron content in milk in very small and some food as a result of the iron has oxalate, carbonate salts and plants and so on, can interfere with iron absorption and utilization, resulting in iron deficiency anemia.

而铁元素在奶类中含量很少并且有些食物中的铁由于有草酸盐,碳酸盐和植物酸盐等,会干扰铁的吸收利用,因而造成缺铁性贫血。

The oxide bound iron, copper to available iron, copper and carbonate bound manganese, zinc to available manganese, zinc has positive effect, but residual iron, copper to available iron, copper and oxide bound manganese to available manganese have negative effect.

铁锰氧化物结合态铁、铜对有效态铁、铜及碳酸盐结合态锰、锌对有效锰、锌具有一定正效应。

At first, the difference of the iron chloride and iron nitrate precursor was studied. By the photoelectrochemical results, the film prepared by iron chloride precursor showed better photoelectrochemical response than the film prepared by iron nitrate precursor, and the reasons were discussed.

研究中首先比较使用氯化铁前驱液与硝酸铁前驱液所制备出的氧化铁薄膜的差异,由实验结果知道,使用氯化铁前驱液的薄膜,其光电化学表现比使用硝酸铁前驱液的薄膜来得好,而研究中也探讨了其可能的原因。

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