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Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome
目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析,并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography,FFA)、吲哚青绿血管造影(indocyanine green angiography,ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例,73.5%),双眼同时患病118例(80.8%);后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%);前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例,98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%);后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障;毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现;炎症活动期FFA典型表现为斑驳状高荧光,ICGA发现脉络膜血管扩张、通透性增高等改变;VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎,随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。
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The average age of onset was 23.4 years. 41 cases had a first involvement of nervous system, 30 cases with hepatic disorder, 4 cases with bone and joint involvement, 3 with renal involvement and 2 with mental disturbance as their first symptoms. Aminoaciduria was demonstrated in 5. Three showed abnormal ECG. EEC findings and studies of copper contents in...
作者对该院在53年中收治的80例住院病人,结合文献复习,从诊断标准、一般资料、首发症状与发病年龄的关系、自发病至确诊时间、发病机制、神经系统症状、精神症状、肝病症状、肾脏损害、骨关节损害、心电图表现、诊断、家族史、预后、分型等十五个方面,进行了综合分析和讨论。
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In all these lesions with downward extension, the red nucleus was always spared. The upward extension seen with the acute lesions was characterized by involvement of the posterior limb of the internal capsulae, accompanied by involvement of the globus pallidus in four and the putamen and external capsule in three.
但当病灶位于中脑-间脑结合处的偏前方时,倾向于累及皮质脊髓束;急性期向上延伸的病灶常累及内囊后肢,伴苍白球受累(4例)和壳核、外囊受累(3例)。
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The incidence of hepatomegaly, splenomegaly, lymphadenectasis, anemia, renal involvement, nervous system involvement and digestive apparatus involvement were higher in children with SLE.
儿童SLE肝脾淋巴结肿大、贫血、肾脏损害、神经系统损害和消化系统损害的发生率比成人组高,儿童组SLE疾病活动指数积分也较成人组高。
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Radiorgaphic changes were more often in right side than in left side. The most commonly affected locations were the superior and basal segments of the lower lobes. Bilobar involvement was frequent. Extensive confluent consolidation was found more often than in upper lobe disease. Endobronchial involvement was proved by bronchoscopy in 28 of 30 patients (93%) and brushing smear for AFB was positive in 13 cases (43%).
胸部X线示:病变右侧多於左侧,最常侵犯部位是下叶背段和基底段,易同时侵犯两个以上肺叶,局部易表现为以段或叶分布的片状浸润实变影。30例行纤维支气管镜检查,28例(93%)镜下有异常改变,13例(43%)刷片抗酸杆菌阳性。
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Two parent brands (low involvement: Tatung, Want Want; high involvement: Apple, White Wood House) and eight extension products were selected for each involvement condition in order to match product types and the width of product line in parent brand as well as product types in extension products.
每涉入度组搭配两个母品牌(低:大同、旺旺;高:苹果、白木屋)与八种延伸产品,使两组在母品牌的产品类型与产品线广度以及在延伸产品的类型上都大致匹配。
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Report. Regarding my involvement in Bible School, I taught two
关,目的是集中信徒的注意在主的再已近,信徒们
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Neither will be allowed any involvement in FIA-sanctioned motorsport, Briatore indefinitely and Symonds for the next five years.
也不会允许任何参与国际汽联认可的赛车,布里亚托利无限期西蒙兹在未来5年。
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The comments are likely to raise new questions about Hirohito's responsibility for Japan's involvement in World War Two.
日记内容很可能会对昭和天皇对日本捲入二战所负的责任提出新的问题。
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The comments are likely to raise new questions about Hirohito"s responsibility for Japan"s involvement in World War Two.
日记内容很可能会对昭和天皇对日本卷入二战所负的责任提出新的问题。
- 推荐网络例句
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I will endeavour to find you some assistance.
我尽力帮你找人帮忙。
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At first I only know bruck is the idol of American younglings, afterwards I returned back to Taiwan ,even in Beijing last year ,I saw her poster everywhere, I was so surprised at her charm.
起初我只晓得布鲁克雷德丝是美国少男少女崇拜的偶像,后来回台湾,甚至去年在北京,居然也四处看见她的海报,才惊讶她的魅力之大。
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Ah may dee:You are chinese living in a democratic country.
你是居住在民主国家的中国人吧。