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Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors.

最终在兴奋性毒性（过度刺激神经元上的递质受体）、钙紊乱、炎症、能量和生长因子缺乏作用下，敏感的神经元发生萎缩、死亡。apoE4与Aβ和tau的异常聚集有关，还可能损伤线粒体和其他细胞骨架。Aβ、tau、apoE和synuclein与其他分子相互作用，影响多种神经活动和存活的信号转导途径。

Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后，易感神经元会萎缩直至死亡，原因可能有兴奋性中毒（神经递质对神经元表面受体的过度刺激引起），钙稳态失衡，炎症反应，能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合，可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应，也可调节不同信号级联反应，这些级联反应对于维持神经元活动性和生存性意义重大。

Other risk factors involve overstrain High Cholesterol diabetes mellitus as well as family history of hypertension.

其它文献要素还有过度紧张胆固醇过高糖尿病高血压家族病史。

A reaction mechanism is proposed to involve one pre-equilibria. First we select a Pt model drugs Na_2PtCl_6 to oxidate L- cysteine and L- cysteine hydrochloride, and study the kinetics of the reaction.

对L-半胱氨酸及其盐酸盐是一级反应的实验结果，建立了半光氨酸一个前期平衡的化学动力学机理，根据该机理圆满解释了实验现象和结果。

Margins can be established; page length can be defined; and many other functions that involve the manipulation of the written word can be performed.

可以建立页的边缘空白；可定义页长；其他凡涉及对字处理的功能都能够执行。

If necessary,key errors may be corrected;words,sentences,paragraphs,or pages may be added or deleted ; margins can be established; page length can be defined; and many other functions that involve the manipulation of the written word can be performed.

若必要的话，键入的错误可以被修正过来，可以对单词、句子、段落或整页进行添加或删除；可以建立页的边缘空白；可定义页长；其他凡涉及对字处理的功能都能够执行。

Here is ancient those who be Di Yao, losing the world personally the big hole large pagoda tree that the first have famed world here, according to textual research, 18 times of bright generation large pagoda tree emigrates, migrate to amount to 18 provinces partly directly 500 many counties, involve surname 869, descendants to there are 200 million people now ever since!

这里古为帝尧之都，身负着"天下第一都"的盛誉；这里有闻名世界的洪洞大槐树，据考证，明代的18次大槐树移民，直接迁徙部分达18个省500多个县，涉及姓氏869个，其后裔现在有两亿人！

The effects of the mechanism on both the efficiency of options investment and on the substitution of the incentive mechanism are analyzed. These substitution effects involve two aspects: the complete substitution to efficiency of investment exercising and the partial substitution to information rents.

重点分析了审核机制对投资期权执行效率的影响以及对激励机制的替代作用，这种替代作用表现为在投资执行效率方面的完全替代和在信息租金方面的部分替代。

In most cases, all that this will involve is the copying and pasting of some simple HTML code onto your website.

在大多数情况下，这将是所有涉及抄袭和一些简单的HTML代码粘贴到你的网页。

But the programs that really work involve intrusive paternalism .

然而真正行之有效的方案无不涉及了冒昧的家长制作风。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。