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The antifungal activities of methanol extract and ethanol extract from Inula,helenium and different extract component from ethanol extract against Sphaerotheca fuliginea,Pseudoperonospora cubensis,Colletotrichum orbiculare,Botrytis cinerea,Fulvia fulva were tested.

以黄瓜白粉菌、黄瓜霜霉菌、黄瓜炭疽菌、番茄灰霉菌、番茄叶霉菌为供试菌，测试了土木香甲醇、乙醇提取物以及乙醇提取物不同萃取组分的抑菌活性。

ObjectiveTo investigate the sesquiterpenoid constituents of Inula helenium L.

目的研究中药土木香的化学成分。

OBJECTIVE: Three sesquiterpene lactones 1-O-acetylbritannilactone, isoalantolactone and britannilactone were isolated from the roots of Inula helenium and the flowers of Inula japonica. The antitumor activities of the three sesquiterpenoids in the cell lines of HeLa, HEC-1, SHIN3, HOC-21 and HAC-2 were measured, and the relationship between structure and activity and the possible mechanisms were explored.

目的： 观察菊科植物中分离出的3种倍半萜化合物异土木香内酯、1-氧-乙酰大花旋覆花内酯和大花旋覆花内酯对体外培养的人子宫颈癌HeLa细胞、人子宫内膜癌HEC-1细胞、人卵巢透明细胞癌SHIN3及HOC-21细胞和人卵巢囊腺癌HAC-2细胞增殖的影响，研究这3种倍半萜化合物的体外抑制肿瘤细胞增殖作用及其结构与活性之间的构效关系，进而探讨3种倍半萜化合物的体外抑制肿瘤细胞增殖的可能机制。

Inula helenium; Extract; Antifungal activity; Phytopathogenic fungi

张文渊；王文桥；张小风；张金林；韩秀英；马志强；李红霞

ConclusionThe two methods are simple and accurate,and can be used to determine the content of tannin in Inula japonica Thunb.

该两种 分析方法简便、准确，可用于旋覆花中鞣质的含量测定。中国论文联盟http：//www.lwlm.com

Our results showed that the mortality from petroleum ether extract of Inula britanica; Ricinus communis methanol ether extract; Photinia serrulate petroleum ether extract after treatment, which showed significantly higher acaricidal activities than the other ones in the concentration of 2 mg/ml.

结果表明：当提取物浓度达到2mg/ml时，旋覆花石油醚提取物，蓖麻子甲醇提取物，石楠叶石油醚提取物的杀螨活性较高。

Objective To establish a quantitative method for determining the content of thymol in Inula nervosa Wall.

目的 建立云威灵药材中百里香酚的含量测定方法。

Key words:Inula nervosa Wall;thymol;HPLC

云威灵；百里香酚；高效液相色谱法

To prepare reference substance for quality control of Inula Britannica L., 1-O-acetylbritannilactone was extracted and separated from chloroform extraction of Inula Britannica L. Chemical structure of the 1-O-acetylbritannilactone product was elucidated by ultraviolet spectrometry, infrared spectroscopy, nuclear magnetic resonance and mass spectrometry, and the results were in agreement with the reference.

从欧亚旋覆花的氯仿提取物中分离制备了1-氧-乙酰大花旋覆花内酯对照品，经紫外光谱、红外光谱、核磁共振和质谱确定结构，其相关数据与文献一致，纯度为99.5%，符合中药化学对照品含量测定用要求。

Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。