查询词典 inhibitory

objective to study the effects of rabdosiae serrae compound preparation on staphylococcus aureus biofilm.methods minimal inhibitory coh centration were tested by doubling dilution,and simulate s.aureus biofilm in vitro be improved brown plate method.the effects of r.serrae compound preparation in different mic on s.aureus biofilm were determined and confirmed by scanning electronic microscope.single layer cells of human floss film were used to test the toxic effects of the compoud preparation.results the mic of s.serrae compound to s.aureus was 128?

目的 研究溪黄草复方对金黄色葡萄球菌生物膜的影响。方法采用试管二倍稀释法测定药物的最低抑菌浓度，用brown平板改良法体外复制金黄色葡萄球菌生物膜模型，并检测溪黄草复方的不同mic浓度对金黄色葡萄球菌生物膜的影响，扫描电镜确认。采用人绒毛膜单层细胞体外培养检测受试药物的毒性作用。结果溪黄草复方对金黄色葡萄球菌的mic值为128？

Methods: A randomized, single blind controlled clinical design was used to accomplish the series clinical trials included 123 cases. The troop of gatifloxation injection with sodium chloride included 20 cases in gatifloxation group and 23 cases in ciprofloxation group; The troop of gatifloxation injection with glucose included 21 cases in gatifloxation group and 19 cases in levofloxacin group; The troop of gatifloxation pivoxil included 19 cases in gatifloxation group and 21 cases in ciprofloxation group. The antibacterial activity of clinical isolates were detected by scrips which contain gatifloxation(5ug/L), levofloxacin (5ug/L), ciprofloxation (5ug/L), spafloxation(5ug/L), cefotaxime(30ug/L), penicillin(10U/L) respectively. The MICs of sixkinds of antibiotics were detected by 2-fold agar dilution method. Result: The common data of patients in the two groups of 3 troops were similiar.

采用区组分层均衡随机单盲试验设计，分别完成甲磺酸加替沙星氯化钠注射液组试验药20例及对照药23例、甲磺酸加替沙星葡萄糖注射液组试验药21例及对照药19例、甲磺酸加替沙星片剂组试验药19例及对照药21例共123例感染患者的临床试验；用K-B法测定临床分离致病菌对加替沙星(5ug／L)、左氧氟沙星(5ug／L)、环丙沙星(5ug/L)、司帕沙星(5ug/L)、头孢噻肟(30ug／L)、青霉素(10U／L)纸片的敏感性，再用按美国国家实验室标准委员会(National Committee for Clinical Laboratory Standards，NCCLS)推荐的琼脂平皿对倍稀释法测定临床分离菌株对加替沙星、左氧氟沙星、环丙沙星、司帕沙星、头孢噻肟、青霉素的最低抑菌浓度(Minimum Inhibitory Concentration，MIC)以了解其体外抗菌活性。

V increased (other than Ara-C) and the inhibitory effect against 〓 improved significantly, especially for ADM. The empty pro-liposomes may undergo three process when hydrated with drug solution: swelling of phospholipid film, fracture of film and resealing to form vesicles.

以空白脂质体前体为载体，对几种临床上常用的抗癌药物的抑瘤活性及毒性进行了研究，研究结果得出：与游离药物相比，5-Fu，阿霉素等药物的抑瘤活性都有不同程度的提高；急性毒性实验表明：除Ara-C外，几种药物的毒性均有所降低，以顺铂最明显。

Using resealed erythrocyte membranes, we further show that lipid scrambling is inducible by raising the intracellular [Ca(2+)] and that K ions have a direct inhibitory effect on this process.

我们采用重新包封的红细胞膜进一步证实，脂质紊乱由细胞内增加的[Ca(2+)]所诱发，而K离子对此过程则具有直接抑制作用。

In the comparison between genotypes, it was found that 1b-NS5As exerted more profound inhibitory effects on IFN activity than 2a-NS5As. The replication of the 2a-NS5A-containing replicons was more sensitive to IFN treatment than that of the 1b-NS5A-containing replicons. By domain swapping, we found the V3 and the C-terminus regions were responsible for the differential anti-IFN effects between genotypes.

我们并收集了共十五名分别感染基因型1b及2a的HCV患者样本，比较两基因型来源的NS5A蛋白质对IFN的抑制效果，结果发现来自基因型1b的NS5A蛋白质确实会比来自基因型2a的NS5A蛋白质具有更强大的IFN拮抗效果。

Tris-(1-aziridinyl)- phosphine oxide and 2-[bis-(2-chloroethyl)-amino]-tetrahydro-1, 3, 2-oxazaphospholidine-2-oxide(Ⅲ, B-518) possess inhibitory action against a variety of animal tumours and have been used clinically. Recently, bis-(1-aziridinyl)-phosphinyl carbamic acid ethyl ester(Ⅱ, AB-100) was found to possess significant activity with low toxicity on experimental animal tumours.

双(2-氯乙基)氨基磷酰二氯与乙烯亚胺在脱水苯或对氧六环中并在三乙胺的存在下进行缩合，生成N，N-双(2-氯乙基)-N′，N-二乙烯基-磷酰胺；与双巯基或双氨基化合物作用，则生成相应的环状磷酰胺、磷酰胺酯以及磷酰胺硫代酯氮芥类化合物。

Enhanced green fluorescent protein-tagged ICL was distributed in a punctate pattern at putative inhibitory synapses,identified by vesicular GABA transporter immunoreactive puncta.

免疫组化实验证明了EGFP-ICL是以PUNCTA的形式分布于抑制性神经元的树突上。

Antinociception and VGSC-modulation of BmK IT2 and BmK AS—1. The results from nociceptive flexion reflex and plantar radiation heat showed: BmK IT2 (a depressant insect-selective neurotoixn) and BmK AS-1 (a new-type β-1ike neurotoxin) have significant antinociceptive effects on rat peripheral nerve system. The antinociceptive effects of BmK IT2 on the carrageenan-inflamed rats were significantly stronger than those on the normal rats. Whole-cell patch-clamping showed: Both TTX-S and TTX-R Na〓 currents induced from rat DRG neurons were significantly inhibited by BmK IT2 and BmK AS—1, and BmK IT2 was more sensitive to TTX-R than TTX-S component. All the results suggested: the peripheral antinociception of BmK IT2 and BmK AS—1 might be attributed to the inhibitory effects of them on the TTX-S and TTX-R Na〓 channel located on the peripheral ends of rat DRG neurons with small diameter.

中文题名特异性钠通道调制剂－长链蝎神经毒素的药理功能研究副题名外文题名 The study of pharmacological function of the specific modulators on voltage-gate Na+ channel-long chain scorpion neurotoxin 论文作者谭智勇导师吉永华研究员学科专业生理学研究领域\研究方向学位级别博士学位授予单位中国科学院上海生命科学研究院学位授予日期2002 论文页码总数93页关键词神经毒素毒理学电压门控钠通道东亚钳蝎钠通道调制剂馆藏号BSLW /2003 /R338 /22 本论文工作利用细胞和行为药理技术系统地研究了东亚钳蝎长链神经毒素的抗伤害性效应、对电压门控钠通道的电生理调制作用、改变胞内离子浓度的效应，并分析了相关的药理功能机制。

The method is based on the inhibitory effect of paracetamol, which is selectively adsorbed by paracetamol-imprinted polymer filled in the CL flow cell, on the chemiluminescence reaction of potassium ferricyanide with luminol in alkaline solution.

将此聚合物颗粒填充在化学发光流通池中，当扑热息痛溶液流过流通池时，扑热息痛分子被填充的印迹聚合物选择性俘获；此时，当铁氰化钾和鲁米诺的混合液流过流通池时，吸附的扑热息痛分子与铁氰化钾发生反应而导致铁氰化钾－鲁米诺反应化学发光信号的降低。

The methods are based on the direct CL reaction of epinephrine with luminol in the presence of potassium ferricyanide and potassium ferrocyanide in alkaline solution or based on the inhibitory effect of paracetamol on the luminol-potassium ferricyanide CL reaction.

人们普遍认为具有不变价态的第二主族元素（碱土金属 Mg》，Caf&，STz&和 B／离于）在通常条件下既没有氧化还原性，也没有催化活性，因而一般认为它们即没有基于氧化还原性的化学发光行为，也没有基于催化活性的化学发光行为。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。