查询词典 inhibitory

Study the inhibitory effect and the mechani sm of helleborus thibetanus france.Polysaccharide on tumor growth.

目的：研究铁筷子多糖的体内抑瘤效应，探讨其作用机制。

Objective: To study the inhibitory effect of docetaxel on the proliferation of human hemangiosarcoma cell line.

目的 ：观察多西紫杉醇( docetaxel，DTX)对人血管肉瘤细胞株的增殖抑制作用。

Research shows that of the human AIDS virus infection and virus cells have inhibitory effect on the treatment and prevention of AIDS was very useful; also Herpetic inflammation lips and mouth ulcers significantly, with broad-spectrum anti-virus capabilities.

研究表明对人类艾滋病病毒的感染和病毒细胞的活性都具有抑制作用，对AIDS的治疗和预防非常有用；还对疱疹性口唇炎和口腔溃疡效果显著，具有广谱抗病毒的能力。

The cells can iniate new tumor after heterogenic transplantation, at certain cell number. 3. The inhibitory effect of DDP, VP-16, TAN II A on GBM cell proliferation was measured.

GBM肿瘤细胞中存在1.33％具有异常增殖能力的BTSC；可以利用条件培养基成功分离和培养BTSC；BTSC在TSM培养环境中可以增殖，形成连续传代的脑肿瘤干细胞球。

The PSCA_3 fragment was selected for its superior expression level in eukaryotic cells.Then the sig-PSCA_3-Fc-GPI genetic fragment was cloned into pVAX1-neo-IRES-GM/B7 vector to construct the final immunological inhanced DNA vaccine pVAX1-PSCA_3-FcGB. Immunofluorescence and flow cytometry were used to confirm the expression of PSCA_3 fragment by transfected into Cos7 cell.Finally,the anti-tumor effect of pVAX1-PSCA_3-FcGB was tested in murine prostate cancer model generated by RM-1 cell line.The animal was immunized with pVAX1-PSCA_3-FcGB DNA vaccine by intramuscular injection plus electroporation,pVAX1 and pVAX1-PSCA_1-FcGB plasmid were used as control.The inhibitory effect of tumor was investigated by observion of forming time,volume and inhibition ratio of tumor.Results:DNA sequencing conformed that the heterological PSCA fusion antigen fragment which was synchronized by overlapping-extending-PCR,was consistent to design.Enzyme digestion analysis showed that the 1 to 4 copies heterological PSCA fusion antigen fragments were constructed successfully.

方法(1)检索GenBank，选择包含人主要T细胞抗原表位序列的人PSCA基因片段，应用异种化抗原设计技术，保留人T细胞抗原表位，设计异种化PSCA融合抗原片段；(2)根据核酸序列按中心模板法设计引物，应用重叠延伸PCR技术拼接合成异种化PSCA融合抗原片段基因，以PCR、限制性酶切和DNA序列测定法进行鉴定：(3)利用DNA限制性内切酶BssHⅡ和MluⅠ酶切后粘端互补的特点，采用同尾酶法构建1—4拷贝异种化PSCA融合抗原片段(PNCA_1-PSCA_4)，并将上述片段分别插入真核表达载体pCI-neo-Fc-GPI中，转染293T细胞，借助免疫荧光+流式细胞术考察插入片段表达效率，最终选定PSCA_3片段进行下一步研究；(4)将sig-PSCA_3-Fc-GPI基因片段自pCI-PSCA_3-Fc-GPI质粒上切下，插入pVAX1-neo-IRES—GM/B7载体中，构建免疫增效DNA疫苗pVAX1-PSCA_3-FcGB，并应用转染Cos7细胞+免疫荧光/流式细胞术方法鉴定其在真核细胞中的表达情况；(5)给8周龄雄性C57BL/6小鼠皮下种植RM-1细胞，制备小鼠前列腺癌模型，并采用股四头肌肌肉注射+电脉冲法(Electroporation，EP)接种DNA疫苗质粒pVAX1-PSCA_3-FcGB，同时接种pVAX1空载体质粒和pVAX1-PSCA_1-FcGB质粒作为对照，通过观察计算免疫动物的成瘤时间、肿瘤体积和抑瘤率，来评价该DNA疫苗在小鼠体内的抑瘤效果。

The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.

在多种SMADS中，SMAD5令我们产生兴趣，基于三个原因：1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加，表明SMAD5可能是早期造血发育的负向调控基因。；2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应，表明它可能介导TGF-β信号转导，后者的异常，包括某些SMADS的功能异常，和白血病紧密相关；3、Smad5基因定位在人染色体5q21，此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关，因此，Smad5被怀疑为白血病抑制基因。

Methods The article applied the orthogonal design to find out the optimum proportion of the rutin, soybean isoflavone and curcumin. The free radical DPPH scaving ratio was used as evaluating standard of orthogonol design and the hominal liver cancer cell SMMU-7721 was used in MTT trial to evaluate the inhibitory ability of the compound. Results The optimum proportion of rutin-soybean isoflavone-curcumin 2:3:7 was achieved.

选取3种天然植物抗氧化物质芦丁、大豆异黄酮、姜黄素，利用正交试验设计选择合适配方，以自由基DPPH的清除率作为正交试验评价标准，并利用人肝肿瘤细胞SMMU-7721进行四甲基偶氮唑盐试验来考察配方体外试验对肿瘤细胞的抑制作用。

Results The weight of tumor was reduced and the inhibitory rate of tumor weight was 36.83% in group B (P.05 compared with group A); incidence of metastatic carcinoma of lung was 100% in group A and metastatic nodules of lung were decreased in groups B and C (P.05 or P.01 compared with group A); lymph node weight in homolateral popliteal fossa and iliac periartery was lighter in group B and C than that of group A (P.05); life-span prolongation rate was 37.77% and 36.77% in groups B and C respectively and survival time did not differ much from that of group A.

结果］髓清丸低剂量组的瘤质量较模型组减少(P.05)，抑瘤率达到36.83%；模型组肺部转移率达100%，髓清丸高、低剂量组的肺部转移结节均较模型组减少，转移率较模型组低（P.05或P.01）；髓清丸高、低剂量组同侧窝、髂动脉旁淋巴结质量均较模型组减小(P.05)；髓清丸高、低剂量组小鼠生命延长率分别为37.77%、36.77%，但生存时间与模型组比较未见显著性差异。

A bacterium isolated from a soil sample collected in lakefront of Peigucuo Lake in Tibet showed strong inhibitory activity to Ustilago hordeum . it was identified as Bacillus polymyxa , named LN-176 based on a preliminary taxonomic study.

从西藏佩古错湖湖边的土壤中分离到一株对青稞散黑穗病菌具有较强抑制作用的细菌，经鉴定为多粘芽孢杆菌，命名为LN-176。

It was concluded that the effects of administration of YT by ip and endermosis is contrary to that of administration by po.The Neostigmine-induced hyperperistalsis of the small intestine was inhibited and the inhibitory effect of Atropine enhanced by ip and sc administration of YT suggesting the mechanism of YT involved the antagonism of Ach. But the contraction of isolated rabbit ileum was not inhibited by YT.

对于羊蹄叶水提取物抗腹泻作用机制的研究表明，腹腔注射、皮肤给药YT可明显抑制新斯的明所致小鼠小肠推进功能亢进，也可加强阿托品抑制小鼠小肠推进运动的作用，从而表明YT的作用机制可能与Ach有关，但家兔小肠离体实验表明YT对Ach所致家兔小肠收缩无明显的抑制作用。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。