查询词典 inhibitors

Polyethylene glycol ethers of alkyl alcohols having the general formula CH3(CH2)xCH2(OCH2CH2)nOH wherein x is 8 to 20 (of which ceteareth-20, steareth-20 and steareth-100 are preferred), poloxamer 185, poloxamer 407, N,N-dimethyl dodecylamine N-oxide, and mixtures thereof, are employed to increase follicular delivery and/or follicular residence time of certain water soluble ornithine decarboxylase inhibitors of which 2-2,5-diamino pentanoic acid and its pharmaceutically acceptable salts, hydrates, optical enantiomers and racemic mixture are preferred.

使用通式为CH3(CH2)xCH2(OCH2CH2)nOH的烷基醇的聚乙二醇醚，其中x为8-20(其中鲸蜡硬脂醇醚-20、硬脂醇醚-20和硬脂醇醚-100是优选的)、poloxamer 185、poloxamer 407、N，N-二甲基十二烷胺N-氧化物及其混合物来提高某些水溶性的鸟氨酸脱羧酶抑制剂的毛囊传输和/或毛囊停留时间，优选的抑制剂是2--2，5-二氨基戊酸及其药学上可接受的盐、水合物、光学对映异构体及外消旋混合物。

Many pharmaceutical companies have focused on developing small molecule inhibitors with possible peroral administration, which are considered promising drugs for rheumatoid arthritis.

许多药厂还在潜心开发能口服的小分子抑制剂，这被认为是有前途的类风湿关节炎治疗药物。

Thus, introduction of statine has become an efficient strategy for the the design of aspartic protease inhibitors.The unique properties of the ferrocenyl group has made ferrocene and its derivatives very popular molecules for biological applications.Among them there are compounds with antiproliferative effect,antibiotics,pesticidal activity,ect.

二茂铁自被合成以来因其具有许多独特的性质而受到广发的应用，许多二茂铁化合物具有抗菌、抗肿瘤、杀虫等活性，用它取代具有生物活性分子中某些芳香环或杂环可以提高整个分子的活性。

Critically, the combination of a tyrosine kinase inhibitor, i.e., IM, nilotinib, or dasatinib, with inhibitors of autophagy resulted in near complete elimination of phenotypically and functionally defined CML stem cells.

关键的是，联合应用酪氨酸激酶抑制剂，如IM、尼洛替尼、达沙替尼和自噬抑制剂可几近全部消除表型及功能定义的CML干细胞。

Subsequent ACE inhibitors were designed with a carboxyl zinc ligand (enalapril, lisinopril, quinapril, ramipril, cilazapril, perindopril) or a phosphinic acid zinc ligand.

后来的ACE抑制剂都设计了一个羧基锌配体（依那普利，赖诺普利，喹那普利，雷米普利，西拉普利，培哚普利）或是一个磷酸锌配体。

The influence of conventional phosphonate mineral scale inhibitors on the deposition of colloidal silica was studied.

硅是地球上含量最丰富的元素之一，也是水环境中最常见的胶体物质[1]，在水中硅的溶解度通常在150～180mg·L-1之间[2]。

A study was made on the dynamic process of the formation of calcium carbonate scale in circulating cooling water system as well as the effects of scale inhibiters on it, with the scale-inhibiting performance of several organic phosphonate scale inhibitors evaluated.

主要研究了循环冷却水系统碳酸钙垢形成的动力学过程及阻垢剂对它的影响，并对几种有机磷酸阻垢剂的阻垢性能进行了评价。

The results showed that conventional phosphonate mineral scale inhibitors do not inhibit silica formation and deposition.

高硅含量的原水在运行过程中常常形成硅垢沉积于设备表面，导致设备传热效率降低及系统管路堵塞[3]。

In order to inhibit its photolysis and enhance its photostability, the flavonoides were selected for photolysis inhibitors of Parsol 1789. It has been found that some flavonoides, for example Rutin, have better effect of i...

研究发现，有些黄酮类化合物对Parsol 1789的光分解有较好的抑制作用，光分解的最大抑制率可达 93.8%。

Tetrahydroisowuinolin derivatives and phthalide derivatives were designed and synthesized on the basis of a PDE4 inhibitor pharmacophore model set up through computer simulation. Some tetrahydroisowuinolin derivatives synthesized were evaluated on their activity against PDE4 for study on the structure-activity relationship.(7-cyclopentyloxy)-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl(4-hydroxy-3-methoxyphenyl)methanone (155) and Methyl 7--6-methoxy-2-(4-methoxy- benzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (170) showed good activity against PDE4, which were chosen as the lead compounds to design and synthesize another analogs in order to develop selective PDE4 inhibitors with better activity.

分别设计合成了以四氢异喹啉和氨基苯酞为骨架的两类小分子杂环化合物，并对部分四氢异喹啉衍生物测试了其相关的生物活性，初步确定了其构效关系，发现了两个对PDE4有较好抑制活性的先导化合物(7-cyclopentyloxy)-6-methoxy-3，4-dihydroisoquinolin-2(1H)-yl(4-hydroxy-3-methoxyphenyl)methanone (155)和Methyl 7--6-methoxy-2-(4-methoxy- benzoyl)-1-phenyl-1，2，3，4-tetrahydroisoquinoline-3-carboxylate (170)。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。