查询词典 inhibitors

They knew as well, from the deelopment of protease inhibitors, that any disruption to the processing of GAG would cause the irus to become noninfectious.

他们从蛋白酶抑制剂发展的过程中也了解到，中断任一步处理GAG的过程，都会使病毒变得没有感染力。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Nonpersistence with renin-angiotensin inhibitors,-blockers, and statins was associated with increased mortality with hazard ratios for death of 1.37 (95% CI, 1.31 to 1.42), 1.25 (95% CI, 1.19 to 1.32), 1.88 (95% CI, 1.67 to 2.12), respectiely.

不能持续应用肾素－血管紧张素抑制剂，阻滞剂和他汀与死亡率增加相关死亡的危险系数分别为1.37 (95% CI， 1.31 to 1.42)， 1.25 (95% CI， 1.19 to 1.32)， 1.88 (95% CI， 1.67 to 2.12)。

However, because of the nonspecificity of the NOS inhibitors and the compensatory interactions among NOS isoforms, the ultimate roles of endogenous NO derived from the entire NOS system are still poorly understood.

然而，由于一氧化氮合酶抑制剂的非特异性以及一氧化氮合酶亚型(神经元型一氧化氮合酶，诱生型一氧化氮合酶，内皮型一氧化氮合酶)之间的相互代偿作用，研究人员对于体内由一氧化氮合酶系统合成的内源性一氧化氮的根本作用还不是很清楚。

Methods MTT colorimetry,a silver colloid technique to identify nucleolar organizer regions and immunohistochemical methods were used to study the effects of the two inhibitors on growth of fibroblasts.

用MTT比色、AgNORs银染和免疫组化技术，观察两种抑制剂对成纤维细胞增殖、AgNORs合成和Ⅲ型胶原表达的影响。

Results show that clicyclohexyl ammonium decanoate has the best inhibiting effect in neutral water and dicyclohexyl ammonium hexylate, dicyclohexyl ammonium octoate and dicyclohyxyl ammonium decanoate are good inhibitors of iron and steel in hydrochloric acid.

研究结果表明，十个碳的二环已胺在中性水中具有最好的缓蚀效果。已酸、辛酸及癸酸十二烷胺等是盐酸溶液中钢铁的优良缓蚀剂。

Single and double octyl phosphate are important anionic surfactants and corrosion inhibitors, which play very important role in the fine chemical and petroleum chemical industry.

磷酸单、双辛酯是重要的阴离子表面活性剂和缓蚀阻垢剂，在精细化工和石油化工行业起着非常重要的作用。

Thus, the suppression of MMP activity with MMP inhibitors was the focus of oncologic research and drug development.

因此用MMP抑制剂抑制MMP的活性就成为肿瘤学和药物研发的焦点。

Solanacearum related gene from potato may be carried outthrough the following ways: 1 abolish the effect of inhibitors in potatoextraction, and establish high performance PCR system of potato; 2 usemore pair of PCR primers; 3 compare suitable P. solanacearum resistantand sensitive variety by AFLP technique.

分析上述实验结果提出分离马铃薯抗青枯病相关基因的可行性方案：1消除抑制剂的影响，建立高效的PCR反应体系；2增力PCR引物对数量；3采用AFLP技术分析合适的抗、感青枯病材料。

In addition,applying nitrification inhibitors could increase vitamin C and soluble sugar contents in pakchoi,and promote N and P uptakes by pakchoi.

另外，3种硝化抑制剂还能显著提高小白菜的维生素C和可溶性糖含量，增强对N，P养分的吸收。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。