查询词典 inhibitors

By spraying polyamines synthesis inhibitors, D-Arg, MGBG (Methylglyoxal bis-guanylhydrazone) and CHA at various concentrations to panicles and flag leaves of indica rice Jinlingxiangnuo (a higher polyamine rice variety) at heading, flowering and grain filling stages, changes in contents and components of PAs in rice grains after harvest were investigated.

多胺(polyamines， PAs)是生物体代谢过程中产生的具有生物活性的低分子量脂肪族含氮碱，是调控生物体生长发育的重要活性物质[1]。PAs在生长发育、细胞增殖、肿瘤发生、编程性细胞死亡(programmed cell death， PCD)、免疫反应及食物过敏症等方面具有重要调节作用[2~6]。

Experiments with mitotic inhibitors, are however, notoriously difficult to control

然而使用核分裂抑制物的实验是非常难以控制的。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Objective: To investigate the expression of Id1 gene in leukemic leukocyte,and determine its relationship with the pathogenesis of acute non-lymphocytic leukemia and chronic myelocytic leukemia,so as to provide some clues to their diagnosis, treatment and prognosis.

目的：研究分化抑制因子-1（inhibitors of differentiation，Id1）在白血病白细胞中的表达，探讨其与急性非淋巴细胞和慢性粒细胞白血病发病的相关性，为白血病的诊断、治疗提供参考。

Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium［J］.

结果显示：高浓度的MS23可减小大鼠胸主动脉环的静息张力，并能抑制KCl和NE引起的缩血管作用。

By means of molecular mechanics and molecular dynamics methods, the binding modes and inte-ractions between newly found matrix melalloproteinases inhibitors, Pyrogallic acid and Myricetin, and MMP-7 were investigated in the present study.

采用分子力学和分子动力学方法，考察了MMPs抑制剂、焦性没食子酸和杨梅黄酮与MMP-7的具体结合方式以及相互作用的情况。

Conclusion; Myricetin and quercetin are inhibitors of PI3K, The inhibitory effects against p110β PI3K of myricetin and quercetin are dose-dependent.

杨梅素和槲皮素是PI3K的抑制剂，杨梅素和槲皮素对PI3K p110β催化亚基的抑制作用与浓度成正比关系。

BACKGROUND: Early after coronary artery bypass surgery, activation of numerous neurohumoral and endogenous vasodilator systems occurs that could be influenced favorably by angiotensin-converting enzyme inhibitors.

背景：冠状动脉旁路移植手术后早期，多种神经内分泌和内源性血管扩张剂系统激活，而ACEI对之可能有正面影响。

BACKGROUND: Early after coronary artery bypass surgery, activation of numerous neurohumoral and endogenous vasodilator systems occurs that could be influenced favorably by angiotensin-converting enzyme inhibitors.

摘要翻译：背景：冠状动脉旁路移植手术后早期，多种神经内分泌和内源性血管扩张剂系统激活，而ACEI对之可能有正面影响。

N,N '- ditertbutyl nitroxyl radical, 2, 2,6,6- tetramethyl-4 - hydroxyl piperdinehy droxylamine and its nitroxyl radical, as inhibitors of the BPO- initiated copolymerization of styrene (M 1 ) with acrylonitrile (M2 ), at 60℃,has been studied.

研究了二叔丁基羟胺，二叔丁基氮氧自由基，2，2，6，6－四甲基－4－羟基哌啶羟胺和2，2，6，6－四甲基－4－羟基哌啶－1－氧自由基对过氧化苯甲酰60℃引发的苯乙烯（M1）－丙烯腈（M2）共聚合的阻聚行为。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。