查询词典 inhibitors

objective to investigate the existence of the erythropoiesis inhibitors.methods the present study included twelve undialyzed esrd patients with anemia.the sera from the uremic patients were added to cfu-e and bfu-e culture in the concentrations ranging from 1.25% to 5%.in vitro cfu-e and bfu-e growth in the presence of sera from esrd patients was compared with in the presence normal human subjects with the use of normal mice bone marrows.results the effects of the sera from uremic patients on cfu-e and bfu-e colony growth in concentrations ranging from 1.25% to 5% were investigated to be dose-dependent.the effect increased with the concentrations increasing of the sera（p＜0.05）.there were not significant inhibitory effect on the cfu-e and bfu-e growth of mice bone marrow in vitro from sera of the normal subjects.conclusion the erythropoiesis inhibitors exist in uremic sera which has a dose-dependent inhibitive effects on the growth cfu-e and bfu-e of normal mice bone marrow cells.

选择12例尿毒症肾性贫血未透析患者为试验组，另选正常健康体检者12例为正常对照组，将实验组、正常对照组血清分别稀释成不同终浓度，采用甲基纤维素细胞培养的方法对小鼠骨髓细胞进行培养，对比不同浓度血清组红系集落形成单位、红系爆式形成单位的集落数。结果在实验组中，与血清浓度为0的浓度组相比，与各浓度组血清共同培养的小鼠骨髓cfu-e和bfu-e的集落数均明显减少，且随血清浓度的增加，小鼠骨髓cfu-e和bfu-e的集落数逐渐减少，各浓度组间差异有显著性（p＜0.05）。结论尿毒症患者血清抑制小鼠骨髓红系祖细胞集落形成，随患者血清浓度的增加，抑制作用增强，具有剂量依赖性。

The enzyme activity of PPO showed a decreasing trend with the prolonging of heat-preservation time, which indicated that PPO was a kind of thermal-susceptible enzyme. Three kinds of inhibitors all had inhibitors on the activity of PPO from C. comas. Among them, the inhibition of NaHSO3 was strongest, followed by ascorbic acid and citric acid.

PPO酶活性随保温时间的延长呈降低趋势，说明PPO是一种热敏感性酶。3种抑制剂对鸡腿菇PPO活性均有抑制作用，其中NaHSO3的抑制作用最强，抗坏血酸和柠檬酸次之。

Gefitinib. 2. Angiogenesis inhibitors: Blocking the angiogenesis process, angiogenesis inhibitors could stop the growth and metastasis, e.g.

血管新生抑制剂则是藉由抑制血管新生的过程，阻断癌细胞的生长及转移现象，如：Bevacizumab。3。

On the basis of the complex structures of AHAS and sulfonylureas inhibitors, systematic molecule docking study of five sulfonylureas inhibitors to AHAS were performed with autodock 3.0 package.

基于酵母乙酰羟酸合成酶与磺酰脲类抑制剂复合物的晶体结构，用分子对接方法对AHAS与5个磺酰脲类抑制剂相互作用的方式进行了系统的分子对接研究。

Due to the VDW interaction between R2 substituent and flavin ring of FAD, the docking complex of inhibitors to AHAS became more stable. It was assumed that the unfavorable electrostatic interaction between the inhibitors and TPP may be the factor which accelerates the degradation of TPP.

其中FAD的加入使AHAS与抑制剂的结合更加稳定，这主要是由于抑制剂的R2取代基与FAD中的平面基团Flavin环间存在的范德华相互作用所致；抑制剂与TPP间存在的静电相互作用可能是加速TPP降解的原因。

Has now been formed, including scale inhibitors, corrosion inhibitors, bactericidal Algicide, cleaning agents, pre-film, chelating agents, distributed agents from the monomer to a wide range of complex pharmaceutical product system, as well as soda ash, calcium chloride , magnesium chloride, sodium nitrite, bromine and bromide products.

现已形成了包括阻垢剂、缓蚀剂、杀菌灭藻剂、清洗剂、预膜剂、螯合剂、分散剂等从单体到复合药剂门类齐全的产品体系，以及纯碱、氯化钙、氯化镁、亚硝酸钠、溴素及溴化物系列产品。

OO from the beginning of a three-year sales of chemical raw materials, specific printing ink, printing ink, sodium hydroxide, liquid (30-50%) hydrochloric acid, electrical cleaning agents, electrical agents, detergents, bactericidal Algicide, corrosion inhibitors, scale inhibitors, polyacrylamide (cation-anion), toluene, glacial acetic acid, such as bleaching, aluminum-based industries to the production of chemical raw materials used.

从二OO三年开始化工原料的销售，具体有印刷油墨、印刷水墨、氢氧化钠、液碱（30-50%）盐酸、电器清洗剂、电器保护剂、除垢剂、杀菌灭藻剂、缓蚀剂、阻垢剂、聚丙烯酰胺、甲苯、冰醋酸等漂染、铝型才行业的生产用化工原料。

Highly active, small-molecule furin inhibitors are attractive drug candidates to fend off bacterial exotoxins and viral infection. Based on the 22-residue, active Lys fragment of the mung bean trypsin inhibitor, a series of furin inhibitors were designed and synthesized, and their inhibitory activity toward furin and kexin was evaluated using enzyme kinetic analysis. The most potent inhibitor, containing 16 amino acid residues with a Ki value of 2.45×10~(-9) M for furin and of 5.60×10~(-7) M for kexin, was designed by three incremental approaches.

本论文研究活性多肽类似物的设计、制备和功能，分为四个部分，采用多肽固相和液相合成的方法，分别合成了活性多肽绿豆胰蛋白酶抑制剂Lys片段长链16肽、天花粉胰蛋白酶抑制剂、癌胚抗原肽、甜味肽等一系列类似物，并测定了这些类似物的生物活性，有以下新的研究结果：1、furin酶抑制剂的设计、制备和功能；2、芳香氨基酸芳环之间的π-π共轭能部分补偿二硫键的作用；3、癌胚抗原肽Gly4被L-Pro替代可增加与HLA-A2分子的结合；4、肽键对甜味肽保持甜味是必须的。

Our experiments confirmed that two known inhibitors DRB and A3 Inhibited the activity of purified recombinant human CK2 holoenzyme, and that quercetin, its derivatives and some tyrphostins exerted stronger inhibitory effect on CK2 than DRB and A3. These results provided important experimental basis and a simple screening method for the development of more effective inhibitors of CK2 and their clinical application in the future.

本结果实验证实纯化的重组人CK2全酶可受到已知抑制剂DRB和A3的抑制，但槲皮素及其衍生物和某些Tyrphostins抑制CK2的作用较DRB和A3更强，这对于开发更有效的CK2抑制剂，为今后应用于临床提供了重要的实验依据和一种较为简便的筛选方法。

The positive expression rates of Tissue Inhibitors of Metalloproteinase-2 protein in the cases of involuting groups were significantly higher than those in proliferating group and vascular malformation groups and normal skin group (P.05). Its difference was significant. Conclusions: Matrix MetallProtinase-2 and Tissue Inhibitors of Metalloproteinase-2 may play an important role in the pathogenesis of hemangiomas through angiogenesis. They may have no effect on vascular malformation and normal skin

血管瘤退化期，TIMP-2表达明显升高，说明 TIMP-2与血管瘤纤维化、消退有关，其机制可能是一方面通过抑制MMP-2介导的基底膜降解而在内皮细胞迁移、聚集中起作用，另一方面直接抑制内皮细胞的增殖及迁移，使内皮细胞高频率调亡，细胞外基质增多，组织出现纤维化，最终导致血管瘤的退化。2、血管畸形和正常皮肤小血管中MMP-2和TIMP-2不表达或表达较弱，说明血管畸形和正常皮肤小血管中并不存在异常的血管生成，据此可以对血管性疾病进行分型、分期，并指导临床治疗。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。