查询词典 inhibitors

In order to understand the drug resistance mechanism of HIV-1 integrase mutually existed for multiple drug-resistant strains to the most potent IN inhibitors diketo acids, three S-1360-resistant HIV-1 strains were selected and molecular docking and molecular dynamics simulations were performed to obtain the inhibitor binding modes.

为了解DKAs引起的多种耐药株共有的耐药性机理，选择3种S-1360引起的IN耐药突变体，用分子对接和分子动力学模拟，研究了野生型和突变型IN与S-1360的结合模式，基于该结合模式探讨了3种耐药突变体所共有的耐药性机理。

Further study indicated that low dose breeding with diphenylene iodonium or apocynin, two inhibitors of NADPH oxidase,significantly suppressed ROS release caused by aerobic exercise.

和H2O2生成均明显增加，而人工饲喂NADPH氧化酶的抑制剂二联苯碘（diphenylene iodonium，DPI）或夹竹桃麻素（apocynin，APO）后，均明显地降低由运动引起的大鼠神经胶质细胞O2^-。

We found that the release of ROS in rat astrocytes was significantly increased by the stimulation of calcium ionophore or opsonized zymosan, which are known to trigger respiration burst in phagocytes by NADPH oxidase pathway. Further study indicated that diphenylene iodonium or apocynin , two inhibitors of NADPH oxidase, significantly suppressed ROS release caused by calcium ionophore or opsonized zvmosan.

我们发现在用吞噬细胞呼吸爆发刺激剂钙离子载体或酵母多糖刺激星形神经胶质细胞时，细胞O〓和H〓O〓产量均明显增加，而NADPH氧化酶的抑制剂二联苯碘(diphenylene iodonium，DPI)或夹竹桃麻素(apocynin，APO)均可以明显地降低刺激剂引起的细胞O〓和H〓O〓产量增加。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

Such epileptoid activities were not influenced by the synaptic receptor inhibitors, and were obviously related to tile persistent sodium current.

这种癫痫样放电的产生不受突触传递阻断剂的影响，但与持续性钠电流明显相关。

Inhibitors including sodium dodecyl sulfate, boric acid, sulfur, and potassium fluoroborate (KBF4) are added to compare the surface quality of AZ91 casting Experimental results show that adding sulfur in green sand obtained AZ91sand castings with satisfied surface quality and adding KBF4 in green sand produced sand castings with best mechanical properties.

实验结果显示添加硫磺，可得到较佳模砂性质且有效控制产生较好的金属表面品质，添加氟硼酸钾有较佳机械性质。

Under the optimum conditions, the extraction rates of the two most important inhibitors, namely formic acid and acetic acid, were up to 84% and 98%, respectively.

在最佳试验条件下，两种最重要的抑制物甲酸和乙酸的抽提率分别达到84%和98%。

The findings of the panel,"Consensus Development Conference on the Use of Nonsteroidal Anti-Inflammatory Agents, Including Cyclooxygenase-2 Enzyme Inhibitors and Aspirin," were published in the September issue of Clinical Gastroenterology and Hepatology, published by the American Gastroenterological Association Institute.

专家组的讨论结果&关于制定非甾体类抗炎药包括环氧化酶－2抑止剂和阿司匹林的应用方案讨论会的共识&发表在美国胃肠病学会出版的9月份的《临床胃肠病学与肝脏病学》杂志上。

We investigated the effects of specificPDE-3 inhibitors (olprinone, milrinone, and amrinone) on contractedhuman gastroepiploic arteries ( n = 70), internal mammary arteries( n = 72), and radial arteries ( n = 70) harvested from a totalof 134 patients, all of whom were undergoing coronary arterybypass surgery.

我们在总共134例行冠脉搭桥手术患者身上采集了人胃网膜动脉（ n = 70）、乳内动脉（ n = 72）和挠动脉（ n = 70），并探讨了特异性 PDE －3抑制剂（奥普力农、米力农和氨力农）对这些血管收缩的影响。

Differential Pharmacologic Sensitivities of Phosphodiesterase-3 Inhibitors Among Human Isolated Gastroepiploic, Internal Mammary, and Radial Arteries

组 I：对照组；组 II：病人向血压计管道吹气，使水银柱上升至30 mm Hg ，持续20秒；组 III：病人挤压橡皮球。20秒后进行外周静脉穿刺。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。