查询词典 inhibitors

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实：两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用，并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著，最佳效应浓度为400nM；2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响：①CREG蛋白对VSMC迁移的影响：刮伤实验发现，加入最佳效应浓度的wtCREG和mCREG蛋白24h后，OB2组迁移能力下降，HITASY组无明显变化；细胞外基质金属蛋白酶-2，9(Matrix metallo-proteinase 2，9，MMP2 ，9)明胶酶电泳检测和Western blot检测结果证实，两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2，9减少，而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases，TIMPs)增加；②CREG蛋白对VSMC分化的影响：加入400nM的wtCREG和mCREG蛋白12h后，OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加，LM-1、FN表达减少；③流式细胞仪分析细胞周期和BrDU染色分析证实，加入400nM的wtCREG和mCREG蛋白后，OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572，HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034；3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用：①免疫共沉淀和免疫荧光双染色分析结果显示，CREG蛋白与M6P/IGF2R存在直接结合；②应用抗体阻断实验：将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中，CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱，而且与加入anti- M6P/IGF2R浓度正相关。

Using the intracellular recording technique for monitoring the excitatory postsynaptic potentials of CA1 pyramidal neuron and delivering an activator of protein kinase C and/or inhibitors of PKC and 〓/calmodulin-dependent protein kinase Ⅱ into postsynaptic cell in hippocampal slices, we studied the role of postsynaptic PKC and CaMKⅡ in long-term potentiation induced by high frequency stimulation at the CA1 synapses made by Schaffer collateral/commissural and perforant pathway afferents.

用电生理学方法在大鼠海马脑片CA1区锥体细胞记录Schaffer侧枝和穿通通路到CA1神经元突触的兴奋性突触后电位，通过送蛋白激酶抑制剂和激活剂进入突触后细胞，我们研究了突触后蛋白激酶C和依赖钙/钙调蛋白的Ⅱ型蛋白激酶在高频刺激诱导的长时程增强产生和维持中的作用。

Thorough analysis of the present hydrate models as the base , contrapose to the deficiencies of present models, we have build a universal natural gas hydrate model base on the state equation which can be used in electrolytical and polarity inhibitors, realized the unite of electrolyte models and alcohol models.

在深入剖析目前水合物模型和实验的基础上，针对现有模型的不足，基于状态方程建立了一个适用于含电解质和极性抑制剂的通用天然气水合物计算模型，实现了电解质与醇类模型的统一。

Increasing the concentration of Cl〓 heightened the corroding rate of carbon steel in the solutions with binary inhibitors.

失重法研究证明，镁离子的存在使钨酸盐的缓蚀作用减弱。

Tyrosine is a precursor of certain alkaloids, and of various phenolic inhibitors such as coumaric acid.

酪氨酸是特殊生物碱和许多酚类抑制剂的前体物质，如：香豆酸。

Plant protease inhibitors as a resisting pest resource was more studied besides Bt gene, the distribution is widely, especially in the leguminosae, solanaceae, gramineae, cucurbitaceae and cruciferae plants.

植物蛋白酶抑制剂是除Bt之外又一个愈来愈研究较多的抗虫基因资源，其分布广泛，在豆科、茄科、禾本科、葫芦科及十字花科等植物中存在较多。

However, alkylating agents, such as cyclophosphamide, and the topoisomerase II inhibitors, doxorubicin and epirubicin, are associated with two types of cytogenetically distinct leukemias after adjuvant chemotherapy.

然而，烷化剂如环磷酰胺、拓扑异构酶II抑制剂、阿霉素、表阿霉素都与辅助化疗后的两种细胞遗传学不同的白血病的发生相关。

Essential drugs for standard topical treatment drugs include metronidazole,azelaic acid, and sodium sulfacetamide-sulfur. second line drugs include dibenzoyl peroxide, benzoyl peroxide,clindamycin,calcineurin inhibitors,and permethrin.

局部治疗红斑痤疮的基本药物有：甲硝唑，壬二酸，复方硫磺制剂；二线药物包括：过氧化二苯甲酰，过氧苯甲酰，克林霉素，钙神经蛋白抑制剂以及扑灭司林等。

By testing the corrosion rate of carbon steel in a simulating corrosion system, the corrosion inhibition performance of three corrosion inhibitors (2-methyl imidazone, N-methyl diethanolamine and thiourea) and their compounds was investigated.

通过测试碳钢在模拟腐蚀体系中腐蚀速率的方法，考察了2-甲基咪唑啉、N-甲基二乙醇胺和硫脲3种缓蚀剂的缓蚀性能及其复配效应。

In a view of chemical structure, most of the HIV-1 integrase inhibitors reported belong to the class of diketo acids or their bioisosters.

该文对近3年来二酮酸类HIV-1整合酶抑制剂的研究进展做简要综述。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。