查询词典 inhibitors

Trypsin inhibitors, the major root storage protein of sweet potato, were purified from different cultivars of Tainong 57 and Tainong 65 of sweet potato Ipomoea batatas

中文摘要胰蛋白酶抑制因子，为甘薯块根中主要储藏性蛋白质。本研究以trypsin-Sepharose 4B 亲和管柱层析方法，从台农57号甘薯块根和台农65号甘薯 Ipomoea batatas

Binding affinities of a series of benzamide inhibitors for trypsin were evaluated by molecular dynamics simulations using a linear response approach.

用基于线性响应近似的自由能预测方法计算胰蛋白酶和苯酰氨类抑制剂的结合自由能。

The u decreased about 50% compared to the control when 360 uM benzoquinone was added into the polysulfide solution. The negative effect of radical inhibitors suggests that free radicals were directly involved in the reaction.

该结果表明，应用传统的液液萃取方法，由于将吸附在悬浮颗粒物上的农药也计算在内，而实际上被吸附农药的生物有效性并不高，因此采用SPME方法评价农药的毒性更为可靠。

Replacement of one benzimidazole fragment with benzothiazole or benzoxazole and optimization of the structure to create the new frame of the compounds were also carried out with the exception to find more potent compounds. The purpose of design and synthesis of these compounds is to investigate the QSAR of this class of compounds with the inhibition of HCV NS3/NS4A protease and eventually to develop more potent inhibitors.

本文首次采用了丙二酰胺与邻芳二胺在微波辐射下制备对称性双芳并唑甲烷化合物、用芳并唑-2-乙酸乙酯与邻芳二胺在微波辐射下制备非对称性双芳并唑甲烷化合物、用4-取代噻唑-2-乙酸乙酯与邻芳二胺在微波辐射下制备非对称性(4-取代-噻唑-2-基)(1H-芳并咪唑-2-基)甲烷化合物等合成路线，共合成了48个目标化合物，其中41个为新化合物，用~1HNMR，ESI-MS，FT-IR，元素分析对这些化合物进行了全面表征，确定了这些化合物的结构，并对部分化合物进行了~(13)CNMR分析。

Benzotriazole derivatives were found to be potent PTP-1B inhibitors, which provide a moderate degree of selectivity to PTP-1B over TCPTP.

苯并三唑类化合物对PTP-1B的抑制活性很高，并且其中一些化合物对PTP-1B表现出了较好的特异选择性，具有良好的药用开发前景。

It is Concluded that the mode of action of pyrimidine benzylamine differs from the other typically commercial ALS inhibitors, such as sulfonylurea and pyrimidine salicylic acid herbicides. Its herbicidal activity is activated by the metabolic processes in the plants.

离体条件下，化合物104-4 IC_(50)＞100 mg／L，而除草剂双草醚IC_(50)值为10~(-5)～10~(-4)mg／L，说明化合物104-4对离体ALS没有抑制作用；活体条件下，化合物104-4对ALS有一定的抑制作用，且随着处理时间的延长，酶活力降低，对ALS的抑制作用增加。

Although these inhibitors including 19 compounds of benzylidene malononitrile family and 13 compounds of 3-substituted indolin-2-ones family, possess quite different structures,a common pharmacophore model with very good stratistical results was determined.

尽管亚苄基丙二腈化合物和3-取代吲哚啉-2-酮系列化合物具有完全不同的骨架结构，但得到的药效团却具有共同的特性，这表明当这两类抑制剂和受体发生相互作用时，采用了相似的结合模式。

The described procedures provide an efficient method to synthesize bicyclic azasugar and thiosugar with novel scaffold as potential glycosidase inhibitors.

本方法提供了一种合成具有潜在糖苷酶抑制活性的氧桥双环氮杂糖和硫杂糖的有效途径。

As a kind of potential drug for treating the type Ⅱ diabetes, the inhibitor of protein tyrosine phosphatase 1B (PTP1B) is an important research field, in which a kind of bidentate inhibitors is the research focus.

作为二型糖尿病的潜在治疗药物，蛋白质酪氨酸磷酸酯酶1B(PTP1B)的抑制剂研究一直备受关注。

As a kind of potential drug for treating the Type II diabetes, the inhibitor of protein tyrosine phosphatase 1B (PTP1B) is an important research field, in which a kind of bidentate inhibitors is the research focus.

中国科学院研究生院，北京 100049摘要：作为二型糖尿病的潜在治疗药物，蛋白质酪氨酸磷酸酯酶1B（PTP1B）的抑制剂研究一直备受关注。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。