查询词典 inhibitors

The main results were as follows:①The genomic DNA extraction method from TCK/TCT teliospore was established, which include cell wall lysis of teliospore by alkali solution, destroying teliospore cell wall for releasing nucleic acid from cytoplasma membrain and elimination of the PCR inhibitors such as pigments or polyphenols component.

论文主要研究结果如下：①优化了碱裂解法破冬孢子外壁-CTAB破坏原生质体，释放核酸-微量DNA过滤柱去除色素、多酚等PCR抑制物质的TCK/TCT冬孢子提取方法，排除了冬孢子细胞壁难破DNA难以提取，三甲胺、色素等PCR抑制物质导致假阴性的难题，采用此方法提取的腥黑穗菌DNA完全适用于PCR扩增。

Temperature and scale inhibitors influence mainly on nuclei formation in the whole reaction process.

从整个结晶过程来看，温度和阻垢剂对晶核生长的反应速率产生较大影响，对晶粒长大反应速率影响较小。

In the study, the results indicated that a certain amount of scale inhibitors and temperature have influence on the rate of crystallization.

在阻垢剂和温度对碳酸钙结晶影响的试验研究中表明，温度、阻垢剂对碳(来源：5fABbbC论文网www.abclunwen.com)酸钙结垢的反应速率产生影响。

For most viruses,there is aneed for antimicrobials that target unique viral molecular properties.Acycloviris one such drug.It is activated into ahuman herpesvirusDNA polymerase inhibitor exclusively by HHV kinases and,thus,does not suppress other viruses.Here,we show that ACV suppresses HIV-1in HHV-coinfected human tissues,but not in HHV-free tissue or cell cultures.However,addition of HHV-6-infected cells renders these cultures sensitive to anti-HIV ACV activity.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.Indeed,an ACV monophosphorylated prodrug bypasses the HHV requirement for HIV suppression.Furthermore,phosphorylated ACV directly inhibits HIV-1reverse transcriptase,terminating DNA chain elongation,and can trap RT at the termination site.These data suggest that ACV anti-HIV-1activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1RT inhibitors.

对大多数病毒而言，都需要有针对其分子特性的靶向杀毒剂阿昔洛韦就是这样一种靶向药物在人疱疹病毒酶的特定作用下，阿昔洛韦被激活成为人疱疹病毒DNA聚合酶抑制剂，因此不能再抑制其它的病毒我们的研究发现阿昔洛韦在共感染人疱疹病毒的组织中可以抑制HIV-1，但在无人疱疹病毒感染的组织或细胞中无此作用然而，加入人疱疹病毒-6感染的细胞却使得其对抗HIV的阿昔洛韦变得敏感我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化实际上，单磷酸化的阿昔洛韦前体药物无需人疱疹病毒的参与即可抑制HIV此外，磷酸化的阿昔洛韦能直接抑制HIV-1逆转录酶，将其阻止在终止位点，从而终止DNA链的延长这些结果提示阿昔洛韦的抗HIV-1活性决定了艾滋病病毒/人疱疹病毒共感染的患者对阿昔洛韦的治疗反应，也有助于开发新的HIV-1逆转录酶抑制剂

Because you are not allowed to take a drug out, for example, if I have a drug that is better than ACE inhibitors, I can not remove the ACE inhibitor from the treatment.

因为不允许撤药，例如，如果有一种药物效果优于ACEI，我们也不能不用ACEI治疗，而只能在使用ACEI的同时，加上新药。

In this paper, we designed a series of pyrrolo[2,1-f][1,2,4]triazine (Compound 51 and 52) as potential novel tyrosine kinase inhibitors.

本文中设计了一系列4，5，6三取代的新型吡咯并[2，1-f][1，2，4]三嗪化合物（化合物51，52）作为潜在的酪氨酸激酶抑制剂。

Recently, the pyrrolo[2,1-f][1,2,4]triazine nucleus have been identified as a novel scaffold for ATP-competitive kinase inhibitors.

最近，吡咯并[2，1-f][1，2，4]三嗪衍生物被证明是一类结构新颖的竞争性的ATP激酶抑制剂。

Trimethylamine and choline have similar structures to the substrate trimethylamine oxide and could be functioning as competitive inhibitors.

三甲胺和胆碱有相似的结构对基体三甲胺氧化物，能功能作为竞争抗化剂。

We studied the effects of different organic solvents and inhibitors on the decolorization of recombinant triphenylmethane dyes decolorization enzyme, expressed extracellularly from Pichia pastoris.

本文在利用毕赤酵母成功分泌表达高活性三苯基甲烷类染料降解酶TpmD的基础上，研究不同有机溶剂和常见酶抑制剂对纯化后的重组脱色酶TpmD活性的影响。

In this paper, we studied M. meretrix ferritin, cathepsin B and caspase genes, which are involved in clam larval shell formation, nutrition, metabolism and apoptosis, respectively. We have cloned the three genes, investigated the temporal and spatial expression profile both at gene and protein level in trochophore (L1), D-veliger (L2), pediveliger (L3) and postlarvae (L4). The potential roles of these proteins were analyzed with specific inhibitors during larval development. Firstly, embryos were found developed into trochophore-like larvae with no shell if cultured at gastrula stage in artificial seawater without iron. Shell-like structures were formed only in the presence of iron. The larvae which had been transferred at L1 stage into ASW developed normal shell. This indicated that iron and iron associated protein are important for larval shell formation. The EST sequence which is homologous with ferritin, which is a principal iron metabolic protein, was selected from the M. meretrix cDNA library. The full-length of ferritin subunit cDNA was cloned by RACE. The results of real-time PCR revealed that the MmeFer mRNA expression changed before and after the larval shell formation.

本论文以文蛤幼虫为研究对象，分别对文蛤幼虫发育过程中贝壳形成相关的铁蛋白、营养及变态相关的组织蛋白酶B及变态过程中细胞凋亡相关的caspase三个基因进行了克隆，分析了基因及编码蛋白在担轮幼虫期(L1)、D形幼虫期(L2)、壳顶幼虫期(L3)和稚贝期(L4)的时空表达特征，解析了其可能的功能，并研究了相应酶类的特异性抑制剂作用对幼虫发育过程的影响，进行了目标蛋白的功能验证，详述如下：研究结果显示，在文蛤胚胎发育到原肠胚时放入不含铁离子的人工海水中培养，发育成无壳的畸形，随着人工海水中铁离子添加浓度的升高，幼虫长出壳状组织接近正常状态；而发育到L1期幼虫放入不含铁离子的人工海水中培养却可以发育出正常的壳，推测铁和铁代谢相关蛋白在幼虫贝壳初始形成有重要的作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。