查询词典 inhibitors

The predicted complex structure of quinazoline type inhibitor with EGF-R, as well as the pharmacophore mapping from CoMFA, can interpret the structure-activities of the inhibitors well and afford us important information for structure-based drug design.

基于定量构效关系研究和复合物结构模型，我们对抑制剂的改造提出了一些新的思路。

From the calculations, it can be found that the van der Waals interactions, the hydrophobic interactions, as well as the H-bonding interactions are crucial for the ligand binding. The 4-phenylamino group can produce strong van der Waals adn hydrophobic interactions with the nonpolar side chains of the residues deep in the binding cleft. The R^1 and R^2 substituents on the bicyclic chromophore can also produce strong van der Waals and hydrophobic interactions with the residues located at the exterior part of the binding pocket. Moreover, the two N atoms of the quinazoline can form H-bonds with EGFR, which will produce significant contribution to biological activities. The calculated nonbonded interactions between anilinoquinazolines and EGFR, as well as the information obtained from the predicted complexes, can interpret the structure-activities of the inhibitors well, which can afford us important information for structure-based drug design.

从模拟结果得到的抑制剂和靶酶之间的相互作用模式表明范德华相互作用、疏水相互作用以及氢键相互作用对抑制剂的活性都有重要的影响，抑制剂的苯胺部分位于活性口袋的底部，能够与受体残基的非极性侧链产生很强的范德华和疏水相互作用，抑制剂双环上的取代基团也能和活性口袋外部的部分残基形成一定的范德华和疏水性相互作用，而抑制剂喹唑啉环上的氮原子能和周围的残基形成较强的氢键相互作用，对抑制剂的活性有较大的影响，计算得到抑制剂和靶酶之间的非键相互作用能以及抑制剂和靶酶之间的相互作用信息能够很好地解释抑制剂活性和结构的关系，为全新抑制剂的设计提供了重要的结构信息。

In a hemagglutination assay, D-Melezitose and Raffinose were the inhibitors of GAL among the sugars tested.

GAL具有较好的热稳定性且其凝血活性不受Ca^2＋、Mg^2＋和Zn^2＋等二价阳离子的影响。

We perform test runs for RASSE by design inhibitors for DHFR and PLA〓 and got the satisfactory results.

我们利用RASSE对DHFR和PLA〓的抑制剂进行了设计，得到了满意的结果。

Via the reacher on LJ-1, we know its water solubility is good,without emulsion inclination, has temperature＆salt-resistant ability,when it used with Zinc dihydrogen phosphate, sodium sulfite and scale inhibitors, the corrosion inhibitor effectiveness can enhanced,when used with Thiourea the corrosion inhibitor effectiveness can decrease,so it can not used with thiourea.

通过对LJ-1缓蚀剂进行性能评价，发现本品水溶解性较好；无乳化倾向性；具有一定的抗温性和抗盐性；将它与磷酸二氢锌、亚硫酸钠和阻垢剂进行复配时，能提高缓蚀剂的缓蚀效果，说明它的配伍性良好，当与硫脲复配时，它的缓蚀效果有所降低，说明它与硫脲不能复配使用。

Evidence from animal models and in vitro experiments suggests that HMG-coA reductase inhibitors are capable of suppressing tumor growth.

动物模型及体外实验结果显示，HMG-COA还原酶抑制剂能抑制肿瘤的生长。

Four 20kg six-month old goats with permanent remen cannula were used to study the effect of three kinds of urease inhibitors acetohydroxamic acid, hydroquinone, yucca extract on nitrogen metabolism, nutrient degradability in rumen and nutrient digestibility.

本研究由4个试验组成，选用安装永久瘘管的6月龄山羊4只，采用4×4拉丁方试验设计，分别饲喂对照组饲粮、乙酰氧肟酸25mg／kg饲粮、丝兰皂甙36mg／kg饲粮、对苯二酚40mg／kg饲粮。

It is going to be quite interesting and exciting with new studies like ATMOSPHERE coming along now looking at renin inhibitors.

这将很有趣，也很令人兴奋，如将要公布的ATMOSPHERE研究也正在探讨肾素抑制剂的作用。

Until very recently, development of clinically effective renin inhibitors remained elusive.

直至最近，肾素抑制剂的临床效应的进展仍是。

Well, no question that rennin inhibitors are a new class of agents, promising agents.

嗯，肾素抑制剂确实是一种新药，一种很有前景的药物。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。