查询词典 inhibitors

Analysis of nuclear extracts of human cells has indicated a similar excision repair mechanism for nick-directed mismatch correction in higher cells, and several reconstituted systems that rely on purified human proteins have been described, such as hMutSα、hMutSβ、hMutLα. Recently, scientists discovered that nickel could be inhibitors of DNA repair. Nickel can greatly enhance the mutagenicity and genotoxicity of compounds in cigarette by inhibiting the nucleotide excision repair pathway in human cells. We have confirmed that nickel could inhibit MMR of E. coli and human and presumed that nickel inhibited repair before MutH incision of the MMR in E. coli. However, there is no evidence of mechanism of nickel inhibiting MMR in human cells.

镍是存在於香菸中的微量金属，近年来有学者发现镍是DNA修复反应的抑制剂，长期抽烟的人会容易因为香菸中化合物攻击DNA而引起突变，进而引起肺癌，而镍会抑制核苷酸移除修复系统（nucleotide excision repair；NER），所以使得体内的DNA损伤无法修复；过去实验室已经证实大肠杆菌的核酸配对错误修复系统会受到镍等重金属的抑制，并且推测出镍的抑制反应是抑制在修复反应的上游nicking的步骤；另外，也证实了人类的核酸配对错误修复系统也会受到镍的抑制，然而还没研究证实会抑制在核酸配对错误修复反应的哪个步骤。

Naphthylamine is the intermediate of various dye products and the major raw materials of various rubber aging inhibitors,ɑ-naphthol produced with ɑ-naphthylamine is the major intermediate of pesticide carbaryl; KT-02 nickel catalyst is used to prepare naphthylamine by nitro-naphthalene catalytic hydrogenation, the product has high purity and high yield, and it's currently one of the best technological conditions, and the catalytic activity of the catalyst does not deteriorate after multiple times of recycle.

萘胺是多种染料产品的中间体，也是多种橡胶防老剂的主要原料，由ɑ-萘胺生产的ɑ-萘酚是农药西维因的重要中间体，KT-02型镍催化剂用于硝基萘催化加氢制备萘胺，产物纯度好、收率高，是目前最佳的工艺条件之一，且催化剂多次套用催化活性不减。

In preclinical studies, oral active DPP-IV inhibitors also promoted beta-cell proliferation, neogenesis, and inhibition of apoptosis in rodents.

临床前研究显示，啮齿类动物经口给予二肽肽激酶IV抑制剂（如sitagliptin与vildagliptin）也引起促进β细胞增生与胰岛新生，抑制β细胞碉亡的作用。

In preclinical studies, oral active DPP-IV inhibitors also promoted -cell proliferation, neogenesis, and inhibition of apoptosis in rodents.

临床前研究显示，啮齿类动物经口给予二肽肽激酶IV抑制剂（如sitagliptin与 vildagliptin）也引起促进β细胞增生与胰岛新生，抑制β细胞碉亡的作用。

This study "confirms for me that there does not appear to be harm in the use of ACE inhibitors or ARB agents right up until the time the patient goes on dialysis, and they should be continued after starting dialysis," said nephrologist Leslie Spry, MD, who was not involved in this research. Dr. Spry, who is medical director of the Dialysis Center of Lincoln, Nebraska, and a spokesperson for the National Kidney Foundation, told Medscape Nephrology that these findings demonstrate that "the benefit is still there late in the disease, and even after the onset of dialysis."

未参与此研究的肾脏科医师Leslie Spry表示，此研究确认了使用ACE抑制剂或ARB制剂没有明显伤害，直到病患开始接受透析，且在开始透析之后还可以继续使用；国家肾脏基金会发言人、内布拉斯加州林肯透析中心医疗主任Spry医师向Medscape Nephrology 表示，这些发现点出了RAS抑制剂的好处在疾病后期、甚至开始透析之后仍然存在。

Comparison of the neurotoxic effects of proteasomal inhibitors in primary mesencephalic cultures［J］.

MPTP对培养的Wistar乳鼠中脑器官型脑片中多巴胺神经元的作用［J］。

Process water, such as organic neutralizer, compressor anti-fouling agent, butter inhibitors, inhibitor agent technology.

如工艺水有机中和剂、压缩机抗垢剂、黄油抑制剂、工艺阻聚剂等。

Objective :To investigate the effect and the mechanism of angiotensin-converting enzyme inhibitors on nitroglycerin to lerance.

目的：探讨血管紧张素转换酶抑制剂对硝酸甘油耐药的影响及机制。

The Effects of Intrathecal Cyclooxygenase-1, Cyclooxygenase-2, or Nonselective Inhibitors on Pain Behavior and Spinal Fos-Like Immunoreactivity

膜内环氧化酶1，环氧化酶2，或非选择性抑制剂对疼痛行为和脊髓 Fos 样免疫反应的影响

In a study of Medicare beneficiaries who were eligible for drug benefits from 1999 to 2004, Dr. Solomon's team assessed the occurrence of cardiovascular events (MI, stroke, heart failure, and cardiovascular death) in 76,082 new users of COX-2 inhibitors, 53,014 new users of nonselective NSAIDs, and 46,558 who didn't use either type of drug.

在 一个对1999至2004年适宜应用该药的医疗保险受益人的研究中，Solomon博士的团队评估了76082名新近应用了COX－2受体抑制剂，53014名新近应用了非选择性非甾体抗炎药，和46558名两类药物均没有应用的患者的心血管事件（心肌梗死，中风，心衰和心血管死亡）发生情况。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。