查询词典 inhibitors

In clinical. acetylcholinesterase inhibitors reduce the breakdown of synaptic acetylcholine, have been modestly effective in improving the cognitive deficits of Alzheimer's disease.The goal of this work is to determine enzyme kinetics and mechanisms of acetylcholinesterase and butyrlcholinesterase inhibition by five cardiovascular drugs, lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride, and two benzodiazepines, diazepam and chlordiazepoxide hydrochloride. All drugs in this study are reversible mixed-type inhibitors of acetylcholinesterase and butyrylcholinesterase. The pKi values for acetylcholinesterase and butyrylcholinesterase inhibition by the cardiovascular drugs are linearly correlated with the molecular weights of the drugs with the slopes of 0.005 and 0.0021, respectively. Therefore, van der Waals' interactions between acetylcholinesterase and the cardiovascular drugs are stronger than those between butyrylcholinesterase and the drugs. This is probably due to a smaller active site gorge and a more significant peripheral anionic substrate binding site of acetylcholinesterase than those of butyrylcholinesterase.

本研究之目的系决定乙醯胆碱酯酵素和丁醯胆碱酯酵素被五种心脏血管药物lovastatin， simvastatin， amlodipine besylate， nifedipine、hydralazine hydrochloride和两种benzodiazepines：diazepam和Chlordiazepoxide hydrochloride的抑制作用之动力学及机转，这些药物都是乙醯胆碱酯酵素和丁醯胆碱酯酵素的可逆性、混合型之抑制剂，实验结果显示，五种心血管药物对於乙醯胆碱酯酵素及丁醯胆碱酯酵素抑制之pKi值和药物之分子量呈直线之关系，斜率分别为0.005及0.0021因此丁醯胆碱酯酵素，与心血管药物间之凡德瓦作用（van der Waals' ）比乙醯胆碱酯酵素与心血管药物间者弱，这可能原因是丁醯胆碱酯酵素之活性区域比乙醯胆碱酯酵素之活性区域更宽广，但丁醯胆碱酯酵素之周边阴离子区域不及乙醯胆碱酯酵素之周边阴离子区域者明显重要，由於五种心血管药物对於乙醯胆碱酯酵素和丁醯胆碱酯酵素抑制之pKi值存在著线性关系表示此种抑制作用系经过共同之反应机理。

However, COX-2 inhibitors generally induce liver injury and it is controvertible to applied COX-2 inhibitors in clinic therapy.

可COX-2抑制剂因易引发肝损伤的副作用，影响了COX-2抑制剂在临床上的应用。

Here we show that phenylarsine oxide and diamide (both were inhibitors for protein tyrosine phosphatases), but not genistein (an inhibitor for protein tyrosine kinases), adenosine, wortmannin and LY294002 (all were inhibitors for phosphatidylinositol 3- and 4-kinases), could inhibit P-selectin exocytosis on activated platelets and could abolish the P-selectin mediated aggregation of activated platelets to neutrophils.

我们发现蛋白酪氨酸磷酸酶的抑制剂phenylarsine oxide和diamide能够抑制P-选凝素从活化的血小板中外排出来，并能够抑制P-选凝素介导的活化的血小板在白细胞表面的粘附，而蛋白酪氨酸激酶的抑制剂genistein，磷脂酰肌醇3-或4-激酶的抑制剂adenosine、wortmannin和LY294002在这些实验中没有作用。

Here we show that phenylarsine oxide and diamide (both were inhibitors for protein tyrosine phosphatases), but not genistein (an inhibitor for protein tyrosine kinases), adenosine, wortmannin and LY294002 (all were inhibitors for phosphatidylinositol 3-and 4-kinases), could inhibit P-selectin exocytosis on activated platelets and could abolish the Pselectin mediated aggregation of activated platelets to neutrophils.

我们发现蛋白酪氨酸磷酸酶的抑制剂phenylarsine oxide和diamide能够抑制P-选凝素从活化的血小板中外排出来，并能够抑制P-选凝素介导的活化的血小板在白细胞表面的粘附，而蛋白酪氨酸激酶的抑制剂genistein，磷脂酰肌醇3-或4-激酶的抑制剂adenosine、wortmannin和LY294002在这些实验中没有作用。

The water treatment chemicals investigated in this work include flocculating agent, germicide, corrosion inhibitor and scale inhibitor. The green properties of water treatment chemicals are determined according to pollution resulted from their uses in oil field and their production processes, while their treatment performences are done from the experimental effects in oil field. The evaluation results are given for flocculating agents, germicides, corrosion inhibitors and scale inhibitors used in Daqing Oil Field.

对于水处理剂产品，本文主要考虑产品的使用和生产过程对环境的污染，以确定产品的绿色属性；通过详细调研，给出了一些产品在使用过程中的处理性能，最终确立油田用水处理剂产品的综合性能，同时针对水处理剂中的四大类产品—絮凝剂、杀菌剂、缓蚀剂和阻垢剂分类进行了比较，为油田用水处理剂产品的使用提供了较有说服力的数据，也为其它油田化学品的使用和评价提供了借鉴。

According to the complex structure of AdSS and its substrate IMP as well as the optimized stable conformation of natural inhibitors, the interaction mode between AdSS and its inhibitors was studied with molecular docking, mechanical optimization and molecular dynamics simulation methods. These results show that the phosphate group and the hydantoin ring of the inhibitors form the pharmacophore model.

基于腺苷酸琥珀酸合成酶与其底物肌苷单磷酸复合物的晶体结构以及获得的天然抑制剂衍生物稳定构象，利用分子对接、分子力学优化及常温分子动力学模拟对AdSS酶与天然抑制剂及其衍生物的相互作用复合物结构进行理论预测。

"Tamoxifen is a good drug, but it looks like aromatase inhibitors may be somewhat better," says James Ingle, MD, a professor of oncology at Mayo Clinic, who is presenting the results on behalf of the Aromatase Inhibitors Overview Group.

"他莫昔芬是一个很好的药物，但它看起来像芳香酶抑制剂可能会好一些，"詹姆斯说，英格尔，医学博士，教授，肿瘤在梅奥诊所，是谁提出的结果代表的芳香化酶抑制剂总览集团。

This multivalent activity of PKC inhibitors is based on a broader antitumor biology than the EGFR and VEGFR inhibitors.

PKC抑制剂比EGFR和VEGFR抑制剂具有更多的多价性是以广泛的抗肿瘤生物学特性为基础。

Multiple chemical inhibitors and specific repressible protein of PKCζ,ζ-PS, can block the signal transmission. Those inhibitors and/orζ-PS protein potentially could be developed targets of inhibition of angiogenesis of liver cancer.

多种抑制剂以及PKCζ假性底物抑制蛋白ζ-PS可以阻抑这一信号传递过程，可能成为抑制肝癌细胞血管形成的潜在的研究目标。

Abstract］ Objective To study the influence of different residual cornea bed of laser in situ keratomileusis on the collagenic construction of cornea through investigating the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in cornea cells for different residual stroma bed after LASIK for six months.

目的 研究不同切削厚度的准分子激光原位角膜磨镶术（laser in situ keratomileusis，LASIK）后兔眼基质金属蛋白酶（matrix metalloproteinases，MMPs）及基质金属蛋白酶组织抑制剂(tissue inhibitors of metalloproteinases，TIMPs)的表达，以探讨LASIK手术的不同切削深度对角膜的胶原结构的影响。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。