查询词典 inhibitor

Objective: To explore the mechanisms resulting in the recurrence of urethral scar which make urethral strictures difficult to be cured, a series experiments were conducted to find potential effective factors involved in urethral scar formation and degradation, including the studies of extracellular matrix component of urethral stricture scar, the characteristics of urethral scar fibroblast, and the effects of urine on urethral fibroblast in vitro, as well as the studies to compare the difference of collagenase activity, type Ⅰ collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the tissues and cultured fibroblasts from normal urethra and strictured urethra respectively, and the studies to investigate the effect of antisense TIMP-1 oligodeoxyonucleotide on cell proliferation and collagenase activity of urethral scar fibroblast.

中文题名尿道瘢痕基础研究副题名胶原酶活性，TIMP-1的表达及其反义基因治疗外文题名 Experimental study on urethral scar-activity of collagenase，expression of TIMP-1，and antisense TIMP-1 gene transfection of urethral scar fibroblast 论文作者黄翔导师杨宇如教授学科专业外科学研究领域\研究方向学位级别博士学位授予单位四川大学学位授予日期2002 论文页码总数104页关键词尿道手术瘢痕胶原酶成纤维细胞尿道瘢痕馆藏号BSLW /2003 /R699 /12 目的：研究尿道瘢痕的细胞外基质的组成，尿道瘢痕成纤维细胞的生物学特性以及尿液对其生长的影响；比较胶原酶活性，金属蛋白酶组织抑制因子-1（TIMP-1）以及Ⅰ型胶原含量在尿道瘢痕和正常尿道组织及体外培养的成纤维细胞中的差异；研究反义TIMP-1寡核苷酸对尿道瘢痕成纤维细胞增殖以及胶原酶活性的影响。

Objective To study the effects of subretinal fluid on the proliferation of retinal pigment epithelium cells and on the activation and translocation of protein kinase C; to investigate the relationship between the proliferation and the changes of PKC in the RPE cells; and to study the effect of PKC inhibitor.

目的 探讨视网膜下液能否引起体外培养的视网膜色素上皮细胞增殖及在其增殖过程中是否出现蛋白激酶C的激活和转位，进一步明确RPE细胞增殖与RPE细胞中PKC信号系统变化的关系及PKC抑制剂的作用。

METHODS: The breast cancer cell lines Bcap37 were treated with different concentrations of vinblatine dissolved in dimethyl sulphoxide or caspase-3 inhibitor (DEVD-CHO, 100 μmol/L) for 3 h. The changes of the proliferation were detected by MTT methods. The apoptosis was determined by observing the internucleosomal DNA cleavage and PI staining, and the proteins of pro-caspase-3 and IκΒ-α were detected by Western blotting methods.

用二甲基亚砜对照、100μmol/L caspase-3抑制剂预处理乳腺癌Bcap37细胞3h后，加入不同浓度的长春碱，以MTT法检测肿瘤细胞增殖能力，以细胞DNA片段分析及PI染色法检测肿瘤细胞凋亡，以蛋白免疫印迹法检测pro-caspase-3和IκΒ-α蛋白的变化。

In experiment 2, taurine and β-alanine (inhibitor of taurine transportation) were offered to male rats of different ages in water, then the effects of taurine on the reproductive organs index, testis tectology and reproductive hormone were investigated.

试验二通过在饮水中添加牛磺酸和β－丙氨酸探讨了牛磺酸对不同年龄雄性大鼠四种生殖器官指数、睾丸组织形态和四种生殖激素的影响。

The first chapter focuses on study of theestablishment of acetylcholesterase's inhibitor's screening model and the algal fractions'inhibitory activity to acetylcholesterase. The second chapter focuses on study of chemicalconstituents of red alga Plocamium telfairia. The third chapter is a brief review aboutresearches on bioactive constituents of seaweeds.

第一章详述了乙酰胆碱酯酶抑制剂筛选模型的建立及海藻组分对乙酰胆碱酯酶抑制活性的研究，第二章详述了红藻海头红化学成分的研究，第三章对海藻生物活性成分研究概况进行了简要的综述。

The influence of acrylic acid and tetradecyl alcohol, amount of catalyst and inhibitor, reaction temperature, reaction time were investigated.

探讨了丙烯酸与十四醇摩尔比，催化剂和阻聚剂的用量、反应温度及反应时间对酯化反应的影响。

A photosensitive resin for UV curing acrylic powder coating has been synthesized by esterification of methacrylic acid and GMA-type acrylic resin at the presence of ethyl acetate as solvent, tetramethylammonium chloride as catalyst, YK as inhibitor.

以醋酸丁酯为溶剂，四甲基氯化铵为催化剂，氮氧自由基为阻聚剂，由甲基丙烯酸缩水甘油酯类丙烯酸树脂与甲基丙烯酸酯化反应制得了UV固化粉末涂料用感光性丙烯酸树脂。

Motilin and gastrin induced contraction of isolated gastric smooth muscle cells in a dose-dependent manner.(2) Motilin- and gastrin-induced antral smooth muscle cell contraction was inhibited by antibodies against Gαi-3. Motilin and gastrin caused an increase of Guanosine-5′-(3-［35S］thio)triphosphate(［35S］GTPγS) binding of Gαi-3.(3) Contraction of antral muscle cells induced by motilin and gastrin was inhibited by the phospholipase C inhibitor U-73122 and the IP3 receptor antagonist heparin.

结果显示：(1)胃动素和胃泌素对胃窦平滑肌细胞均有收缩作用；(2) Gαi-3抗体可抑制胃动素和胃泌素加强胃窦平滑肌细胞的收缩，胃动素、胃泌素明显增加Gαi-3抗体与［35S］GTPγS的结合；(3)磷脂酶C抑制剂U-73122、三磷酸肌醇受体拮抗剂肝素可抑制胃动素和胃泌素引起的胃窦平滑肌细胞的收缩。

Objective: To investigate the cellular signal transudation pathway of vascular smooth muscle cell proliferation and cytokins secretion stimulated by oxidized low density lipoprotein and insulin-like growth factor-1 (IGF-1) and the intervention effect of HMGcoA reductase inhibitor, atovastatin and immune supppressor, rapamycin.

目的：探讨氧化低密度脂蛋白，胰岛素样生长因子-1(IGF-1)促血管平滑肌细胞增殖及分泌功能改变的细胞内信号转导机制及三羟基三甲基戊二酰辅酶A抑制剂阿托伐他汀与免疫抑制剂雷帕霉素干预作用。

Objective: To investigate the cellular signal transudation pathway of vascular smooth muscle cell proliferation and cytokins secretion stimulated by oxidized low density lipoprotein and insulin-like growth factor-1(IGF-1) and the intervention effect of HMG-coA reductase inhibitor, atovastatin and immune supppressor .rapamycin.

目的：探讨氧化低密度脂蛋白，胰岛素样生长因子-1(IGF-1)促血管平滑肌细胞增殖及分泌功能改变的细胞内信号转导机制及三羟基三甲基戊二酰辅酶A抑制剂阿托伐他汀与免疫抑制剂雷帕霉素干预作用。

Recall that, in the Kolmogorov axiomatization, measurable sets are the sets which have a probability or, in other words, the sets corresponding to yes/no questions that have a probabilistic answer.

延期开工的Kolmogorov宣布要衡量所有套职能有限许多坐标限制在于衡量子寅。换句话说，如果是/否的问题回答f可看的价值观念在许多最有限坐标，然后它有一个概率的答案。

The experimental results showed that the algorithm can filter singular points and remain fixity of the target edge.

实验表明：基于模糊理论的图像智能滤波方法比常规图像滤波方法运算量小，它既能去除奇异点，又能保持图像中目标的边缘不变性，具有很好的滤波效果。