查询词典 inducing

Abstract］ Objective:To explore the apoptosis inducing activity of Momordin from Momordica charantia seeds and its effect on the expression of Bcl2 gene and proliferating cell nuclear antigen.

目的：观察苦瓜蛋白是否具有诱导K562细胞凋亡的生物学活性，探讨苦瓜蛋白对K562细胞Bcl2及PCNA表达水平的影响及其作用的分子机制。

Objective To investigate the prospect for clinical use of novel retinoids YS 904012 and R 9158 in combination with IFN-γ in inducing differentiation of acute monocytic leukemia.

目的 探讨新研制的维甲类查尔酮酸R 9158和YS 904012联合γ干扰素在急性单核细胞白血病分化疗法中的应用价值。

Recombinant human Mullerian inhibiting substance suppresses the growth of MISIIR-positive ovarian cancer cells by inducing apoptosis and cell cycle arrest. We predict that rhMIS might be a new target to treat human ovarian malignancies.

重组人苗勒抑制物可以抑制MISIIR蛋白表达的卵巢癌细胞增殖、诱导其凋亡、阻滞细胞周期，这有望成为治疗卵巢癌的一个新靶点。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

The recent experimental studies have shown that bone marrow stem cells are capable of regenerating infracted myocardium and inducing myogenesis and angiogenesis, which improving myocardial perfusion and cardiac function.

目前的研究表明，移植的骨髓干细胞可以分化为心肌细胞，使心肌梗死瘢痕区血管和心肌再生，改善缺血心肌血供，改善心脏功能。

To study the effect and mechanism of fraction C isolated fromN Naja naja Actra Venomin inducing apoptosis of human leukemia cells.

目的：研究眼镜蛇蛇毒组分C诱导白血病细胞凋亡的作用及机制。

Methods:To observe the contents of total bilirubin and alanine aminotransferasein serum ,the contents of malondialdehyde , activity of superoxide dismutase , level of nitrogen monoxide in serum and liver tissue ,hepato-pathohistologic changes by CCl4,αnaphthalin fluorescein isothiocyanate inducing acute liver injury and icterus respectively in mice by po, the effects of sedum lineare thunb on the biochemical changes were analysed.

分别采用四氯化碳（CCl4）、α萘异硫氰酸酯一次性灌胃中毒致小鼠急性肝损伤及黄疸模型，测定血清谷丙转氨酶、总胆红素含量及血清、肝组织中丙二醛、超氧化物歧化酶、一氧化氮水平和观察肝组织病理变化，分析佛甲草对上述指标的影响。

Hemin can retard the occurrence and development of nephrogenic hypertension of chronic renal failure rats. This role has much to do with inducing the expression of HO-1 in the kidney, increasing the concentration of carbon monoxide in the plasm and reducing the level of ET-1 in the kidney and plasm.

结论hemin组具有延缓慢性肾功能衰竭大鼠高血压的发生和发展作用，这种作用与hemin诱导肾脏HO-1表达、增加血浆CO浓度，降低肾组织和血浆中的ET-1水平有关。

Objective: To explore the influence of serum of different concentrations towards co-cultured neuroepithelial stem cells and Schwann cells, and further to seek the factors inducing the orientation differentiation of neural stem cells.

目的：探讨血清对联合培养神经上皮干细胞与Schwann细胞的影响，进一步寻求诱导神经上皮干细胞定向分化的影响因素。

Based on these results and inferred to related reports from other labratories, it was possible to make some analyses and conclusions or inferrences:(1) CD〓AK with tumoricidal activity were induced and expanded in number througth costimulation of PBMC with anti-CD〓 McAb . and r IL-2 ;(2) CD〓AK induced and expanded in such manner did exibit more potent proliferation·ability and cytotoxicity which maintained for lonser time than those of LAK cells, thus CD〓AK was a new variety of antitumor effector cells worth to be explored;(3) CD〓AK could mediate MHC nonrestricted cytotoxicity and kill tumor target cells through inducing necrosis and apoptosis;(4) Normal mature lymphocytes of PBMC could be induced to proliferate and /or to die from apoptosis when they were costimulated by anti-CD〓McAb and rIL-2. Both proliferation and apoptosis were existing in the same cultivation system sugsesting that the presence of rIL- 2 might provide some accessary signals for apoptosis.

以这些结果为基础并参考其它有关文献可能做出如下分析与结论或推论：(1)用抗CD〓单抗和rIL-2共刺激外周血单个核细胞能诱生扩增出具有杀瘤活性的CD〓AK细胞，(2)与LAK相比，用这种方法诱生扩增的CD〓AK增殖能力强、细胞毒活性强而且维持时间长；CD〓AK是一类值得开发的抗瘤效应细胞；(3)CD〓AK能够介导MHC非限制性细胞毒活性，可以通过诱导靶细胞坏死和/或凋亡杀伤肿瘤细胞；(4)正常外周血单个核细胞中的成熟淋巴细胞在受到抗CD〓单抗和rIL-2共同刺激后既可诱导增殖也可诱导凋亡，两者并存于同一体系，推测rIL-2的存在可能为细胞凋亡提供一些辅助信号。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。