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Crack sliding induced microcrack surface normal dilation and normal dilation induced microcrack further self-similar propagation are considered, the ineracting of sliding and propagation is clarified. The fourth-order tangent homogeneous stiffness tensor of shear microcrack is deduced, and at last the constitutive model of low porosity is expressed in increment formulation though unit sphere surface integral.

3在评述当前常用的微裂纹滑移准则的基础上，提出了本文的滑移准则，考虑了微裂纹滑移引起的裂纹面法向膨胀，以及由法向膨胀引起的微裂纹进一步扩展，阐明了滑移-扩展相互影响的细观力学机制。

The elastic strains induced in the epicentral region by the passage of the seismic wavefield generated by the largest of the nuclear tests, the May 11 Indian test with an estimated yield of 40 kilotons, is about 100 times smaller than the strains induced by the Earth's semi-diurnal (12 hour) tides that are produced by the gravitational fields of the Moon and the Sun.

由核试验产生的震动波经过而诱发了在震中区域的弹性应变。5月11日估计有40千吨产物地印度的核试验，比由月球和太阳引力引起的12小时一次的潮汐引发的应变小100倍。

The elastic strains induced in the epicentral region by the passage of the seismic wavefield generated by the largest of the nuclear tests, the May 11 Indian test with an estimated yield of 40 kilotons, is about 100 times smaller than the strains induced by the Earth's semi-diurnal (12 hour) tides that are produced by the gravitational fields of the Moon and the Sun.

核试验产生的震动波途径震中，诱发了在震中区域的弹性应变。发生在5月11日约40千吨级的印度核试验，比月球和太阳引力引起的12小时一次由潮汐引发的应变小100倍。

The elastic strains induced in the epicentral region by the passage of the seismic wavefield generated by the largest of the nuclear tests, the May 11 Indian test with an estimated yield of 40 kilotons, is about 100 times smaller than the strains induced by the Earth's semi-diurnal (12 hour) tides that are produced by the gravitational fields of the Moon and the Sun.

大规模核试验产生的震动波途径震中，诱发了在震中区域的弹性应变。发生在5月11日约40千吨级的印度核试验，比由潮汐引发的应变（月球和太阳引力引起，每12小时一次）小100倍。

So far, because of the components of AN are very complex, the mechanisms of AN-induced cytotoxicity to cause cell aberrations and oral diseases are not clearly understood. The purpose of this study is trying to investigate the roles of two check point kineses: Chk1/Chk2 in the ANE-induced geno- and cytotoxicity.

但由於槟榔成分过於复杂，对於槟榔成分究竟是如何造成各种细胞变异甚至口腔疾病的详细致病机转目前并不清楚，因此本篇研究的主要目的即是针对细胞内两种细胞周期检查点Chk1/Chk2在槟榔成分所造成的基因与细胞毒性中所扮演的角色进行探讨。

Results MTT showed that the As2O3 inhibited the growth of SGC-7901,it induced G(2)/M cell cycle arrest, electron microscope showed that As2O3 could induced cell apoptosis and necrosis.

结果 ①MTT法证实As2O3对SGC-7901细胞生长有抑制作用，并呈剂量－效应关系。②流式细胞仪分析As2O3处理SGC-7901细胞后细胞滞留于G2/M期，并可见凋亡峰。

Result: The series of Muskone can improve myocardial ischemia and infarction in experimental canines, and relieve significantly the degree of myocardial ischemia determined by epicardial electrogram mapping,decrease the range of myocardial ischemia determined by epicardial electrogram mapping and decrease infarction zone determined by N-BT staining method. And it has a significant inhibition on activity of ET induced by myocardial ischemia and infarction, and increases 6-Keto-PGF1αand 6-Keto-PGF1α/TXB2 induced by myocardial ischemia.

结果：冠心苏合丸系列组方具有明显改善犬急性心肌缺血和心肌梗死的作用，明显减轻由心外膜电图标测的心肌缺血程度及范围；减小经N-BT染色所显示的梗死区；对心肌缺血及心肌梗死引起ET的活性有明显抑制作用，同时升高血浆6-Keto-PGF1α和6-Keto-PGF1α/TXB2的比值。

The effects of phenolic acid compounds in vegetables and fruits on metabolicactivation of BaP in rats,as well as 〓 and TCA induced lipid peroxidation inmouse and Salmonella typhimurium TA104 cells were investigated using DNAadducts as a biomarker to assess DNA damage induced by xenobiotic carcinogens.BaP was used to study the genotoxic carcinogenesis,while 〓 and TCA were usedto study the non-genotoxic carcinogenesis.The possible protection mechanisms ofphenolic acid compounds on DNA damage were studied.

本研究根据化学致癌过程的遗传毒性和非遗传毒性机理，以DNA加合物作为机体接触外来化学物而导致DNA损伤的生物学标志物，通过观察酚酸类化合物对大鼠体内BaP活化代谢以及〓和TCA诱导小鼠肝微粒体脂质过氧化的影响，及酚酸类化合物对BaP和TCA诱导的沙门氏菌TA100和TA104形成DNA加合物的影响，探讨蔬菜、水果中酚酸类化合物对外来化学物诱导的DNA损伤的保护机制。

A careful monitoring of potassium levels is needed when using haloperidol because it might exacerbate APD prolongation induced hypokalemia and increases the risk of Torsades de points induced by QT interval excess prolongation.

在使用氟哌啶醇时应密切监测患者血钾浓度，氟哌啶醇可能加重低血钾时APD延长的程度，增加QT间期过度延长诱发Tdp的风险。

Methods: rabbit bone marrow mesenchymal stem cells were purified, and then cultured in inducing medium containing transforming growth factor-β1; mtt assay was employed to evaluate the proliferative activity of induced cells; immunohistochemical assay was used to detect the expression of type ⅱ collagen; induced cells were transplanted into the knee of rabbit, and x-ray photography was employed to observe the repair and formation of cartilage.

纯化兔骨髓间充质干细胞；用含转化生长因子β1的诱导液培养骨髓间充质干细胞；以mtt测定诱导细胞的增殖活性；免疫组化检测ⅱ型胶原蛋白的表达；诱导后的细胞移植于白兔膝关节内，x线摄片观察软骨修复形成情况。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。