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In this study we provide evidence that inhibition of Rho kinase activation or myosin contractility abrogates PMA-induced apoptosis, and turns cells to undergo PMA-induced differentiation program, suggesting a switching role for the RhoAJROCK/myosin contraction pathway in cell fate decision.

在我们的研究中发现抑制Rho kinase 的活性或肌动蛋白收缩将阻断凋亡的发生，而使细胞全数走向分化，证实了RhoA/RocK 活化所造成的myosin 滑动收缩的机制，对细胞因应刺激而决定其命运的过程中扮演一决定性角色。

In io administration of anti-EGF antibody abrogates both the acceleration of the recoery of blood flow in the ischemia-induced limbs by M-CSF and the augmentation of the mobilization of EPCs induced by M-CSF.

而体内给予抗EGF抗体可消除M-CSF诱导的血流恢复加快和EPCs动员增加，提示M-CSF动员EPCs通过增加EGF的生成以促进缺血组织血流的快速恢复，同时提示EGF主要生成于髓系细胞。

Blood-cooling and blood flow-promoting drugs has the effect of prevention and treatment for the early radiation-induced lung injury, Middle-dose and high -doses group were better than small-dose, however theres no difference between them. Suggest that using the adequate doses of blood-cooling and blood flow-promoting drugs would not enhance the effects of prevention and cure for radiation-induced lung injury if the doses of drugs were aggrandized.

早期应用凉血活血方对放射性肺损伤有防治作用，大、中剂量组的防治效果明显好于小剂量组，但大、中剂量两组无差别，提示凉血活血方中剂量即为较理想有效剂量，剂量加倍而疗效并不增强。

Objective To observe the morphology of neuronal death in nucleus amygdalae of rats after status epilepticus induced by lithium-pilocarpine, and correlate this with markers of DNA fragmentation that has been associated with cellular apoptosis. MethodsSE was induced for 3 hours with LPC.24 or 48 hours later the rats were killed.

目的 观察锂-匹鲁卡品致痫鼠杏仁核神经元损伤的形态学改变，并检测细胞凋亡相关的DNA碎片标志物方法用LPC诱发大鼠癫痫持续状态(status epilepticus，SE)3 h，于癫痫中止后第24小时和第48小时处死动物。

Part Ⅳ Further Studies on Effects of Anti-S. japonicum Egg Granuloma and Hepatic Fibrosis Induced by SCP Combining Reagent Further to probe the effects of anti-S. japonica and antiS. japonicum hepatic fibrosis induced by shark cartilage powder cooperating"425"preparation.

第四部分 SCP合剂诱导的抗血吸虫卵肉芽肿及抗肝纤维化效应的进一步研究为进一步探讨鲨鱼软骨粉联用&425&制剂诱导的抗血吸虫卵肉芽肿及抗血吸虫性纤维化效应。

MethodsThe swelling of ears in mice induced by xylene and the proliferation of granulation induced by cotton balling were adopted.

方法采用致大鼠慢性棉球肉芽肿和二甲苯致小鼠耳肿胀的方法，观察不同炮制时间的豨莶草对棉球肉芽肿的重量及小鼠耳肿胀度的影响。

It was a conviction that these people did not differ from us in principle, which induced me to define the principles which I deemed orthodox, and to urge a reunion on these principles; and I am induced to hope it has conciliated many.

我以前就坚信，这些人在原则上与我们并没有分歧，这个信念使我从事于界定我认为被大众认可的那些原则，我呼吁在这些原则下团结起来；而且我确信这确实团结了很多人。

Here we present evidence that NMDA receptors not only contribute to normal synaptic responses induced by stimulation of local layer V or white matters, but also contribute to generation of action potentials induced by a depolarizing step applied to the soma.

我们的研究表明，NMDA受体不仅参与刺激前扣带皮层的第五层细胞或刺激白质诱导的突触反应，而且参与在胞体施加去极化跃阶电流诱导的动作电位的发放。

After dialyzing for 10～20 min, SNP at a concentration of 1 μmol/L increased the induced responses to innocuous mechanical stimulation and decreased those to noxoius mechanical stimulation. The induced responses to both innocuous and noxious mechanical stimulations were all decreased after dialyzing the same dose of SNP for 20～30 min. The decrease was shown within 7～15 min dialysis when SNP was used at a concentration of 20 μmol/L.

脊髓深层神经元透析1 μmol/L SNP， 10～20 min后，非伤害性机械刺激诱发的反应增强，伤害性机械刺激诱发的反应减弱；透析20～30 min后，伤害性和非伤害性机械刺激诱发的反应均减弱；透析20 μmol/L SNP 7～15 min内伤害性和非伤害性机械刺激诱发的反应均降低。

Results 甀ntrahepatic vascular diseases, liver tissues diseases and the expressions of VEGF were different in different time of experiment induced by CC14. In earlier periods (2 to Swk) of rats? liver tissues induced by CC14, the inflammatory was significant. Fatting degeneration was seen in hepatocytes around central veins and part of small vesells.

早、中期（2～5wk），肝组织炎症反应显著，中央静脉及部分小血管周围肝细胞脂肪变，VEGF阳性肝细胞主要分布在脂肪变区域；晚期（8～12wk）则肝组织炎症反应轻微，但肝细胞病变显著，血管破坏、血管及成肌纤维细胞增生更趋明显，并见有局部纤维瘢痕形成，假小叶内肝组织肝窦扩张或毛细血管化，其VEGF示阳性。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。