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More importantly, blocking CPT-induced Noxa using specific siRNA significantly reduces the apoptosis response, indicating that Noxa is an essential mediator for CPT-induced apoptosis.

通过免疫共沉淀实验，我们证明了不管有没有CPT处理的情况下Noxa都可以和Mcl-1相互作用，说明Noxa和Mcl-1之间应该存在一个平衡，从而调节细胞凋亡。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

Interestingly, the hsp70 message is only patchily induced within the ischemic core but is markedly induced in neurons of the penumbra at 4 to 24 hours.

有趣的是，hsp70信息在缺血核心部位仅是被不规则地导入了，却在4到24小时内明显地被导入了半暗带的神经元。

Inter-estingly, the hsp70 message is only patchily induced within the ischemic core but is mark-edly induced in neurons of the penumbra at 4 to 24 hours.

有趣的是，hsp70信息在缺血核心部位仅是被不规则地导入了，却在4到24小时内明显地被导入了半暗带的神经元。

Interestingly, the hsp70 message is only patchily induced within the ischemic core but is markedly induced in neurons of the penumbra at 4 to 24 hour s.

有趣的是，hsp70信息在缺血核心部位仅是被不规则地导入了，却在4到24小时内明显地被导入了半暗带的神经元。

METHODS: the supernatants of cultured spleen's lymphocytes induced by ConA were injected into mice peritoneally,kinetics of plasma corticotropin releasing hormone,adrenocorticotropic hormone and corticosterone in mice were tested at different time (0.5,1,2,4,6 h),or tissue of hypothalamus pituitarium or adrenal was stimulated with supernatants induced by ConA,and the secretion of CRH, ACTH and CORT were observed.

采用ConA诱导淋巴细胞培养上清液给小鼠腹腔注射，测定不同时间(0.5，1，2，4，6 h)的小鼠血浆中CRH，ACTH，皮质酮产生的动力学，同时在体外用ConA诱导上清液分别与下丘脑，垂体，肾上腺组织共同培养后观察CRH，ACTH，CORT分泌情况。

Effect of A_3 on dimethylbenzene-induced mice ear edema Method:After peroral A_3 3 days, the mice ear edema models induced by dimethylbenzene were prepared. The mice ear edema was tested at 1 h.

A_3对二甲苯所致小鼠耳廓肿胀的影响方法：连续灌胃给药3天(1次/天)后，采用二甲苯制备小鼠耳廓肿胀的炎症模型，观察二甲苯致炎后1 h药物对小鼠耳肿胀的影响。

Effect of A_3 on carrageenin-induced rats paw edema Method:After peroral A_3 4 days, the rats paw edema models induced by CGN were prepared. The rat paw edema was tested at

A_3对角叉菜胶所致大鼠足肿胀的影响方法：连续灌胃给药4天(1次/天)后，采用角叉菜胶制备大鼠足趾肿胀的炎症模型，观察角叉菜胶致炎后1，2，4，6 h药物对大鼠足趾肿胀的影响。

But in the animal spherocyte anemia model induced by the antibody, which was put forward by Wen zongyao et al, all the microrheological and biophysical indexes of reticulocytes were better than that in the anemia model induced by the phenylhydrazine injection, for it was closer to the normal physiological conditions.

但观测表明，由文宗曜[1]等人提出的用抗体诱发动物球形红细胞贫血的模型中，网织红细胞的各种微观流变学指标及生物物理指标均优于苯肼注射模型，比较接近正常生理条件。

The inhibition of EGCG on UPS-induced TNF-a production was mediated at least in part through blocking of p38 MAPK pathway. In addition, EGCG had a beneficial effect on acute lung injury induced by oleic acid in mice. The inhibition of phosphated p38 MAPK and the ultimate reduction of TNF-a in serum may be involved in its mechanism.

另外，EGCG对油酸型小鼠急性肺损伤有一定保护作用，其作用机制可能与其能抑制p38 MAPK的磷酸化，并减少TNF-a的合成与释放有关。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。