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In vitro, K-ras mutation ASODN could apparently inhibit the growth of Patu 8988 cells （ in a certain degree of dose-dependent and time-dependent manner）,induce apoptosis and decrease the expression of K-ms protein and K-ras mRNA in contrast with SODN, RODN and control groups.

针对K-ras基因第12密码子点突变的反义寡核苷酸可明显抑制人胰腺癌Patu 8988细胞生长，促进细胞凋亡，其机制可能是通过下调K-ras蛋白和K—ras mRNA表达而起作用。

Methods DCs were prepared from peripherad blood mononuclear induce d with gra-nulocyt e/macrophage colony-stimulating factor and interleukin-4. Apoptosis of glioma cells were induced with γ-radiation. We design these experiment groups including (1) coculture of DCs and apoptotic glioma cells and T cells,(2) coculture of DCs and U937 cells and T cells,(3) coculture of DCs and cultured glioma cell and T cells,(4) coculture of Des and T cell.

用粒－巨噬细胞集落刺激因子加白介素－4(IL-4)从人外周血分化、诱导DCs、γ-射线在体外诱导培养的人脑胶质瘤细胞凋亡，将DCs、T淋巴细胞和凋亡胶质瘤细胞共培养，同时设计不同类型肿瘤细胞（U937及培养胶质瘤细胞）作对照，分离、富集DCs、T淋巴细胞进行免疫应答及肿瘤细胞杀伤试验。

Methods DCs were pre pared from peripherad blood mononuclear induce d with gra-nulocyt e／macrophage colony-stimulating factor and interleukin-4.Apoptosis of he patochlangioma cells were induced with γ-radiation.We design these experiment groups including(1)coculture of DCs and apoptotic cancer cells and T cells,(2)co culture of DCs and necrosis cancer cells and T cells,(3)coculture of DCs and cul tured cancer cell and T cells,(4)cocultu re of DCs and T cell,(5)cocuture of DCs and cultured cancer cell.

用粒-巨噬细胞集落刺激因子加白介素-4(IL-4)从人外周血分化、诱导DCs、γ-射线在体外诱导培养的人胆管癌细胞凋亡，将DCs、T淋巴细胞和凋亡胆管癌细胞共培养，同时设计不同类型肿瘤细胞(坏死胆管癌细胞及培养胆管癌细胞)作对照，7d后，分离、富集DCs、T 淋巴细胞进行免疫应答及肿瘤细胞杀伤试验。

Peripherial blood mononuclear cells pulsed with GST-MAGE-3 were able to present antigen to T lymphocytes, activate antigen-specific CTLs and induce special antitumor immune responses in vitro.

经GST-MAGE-3蛋白抗原冲击的胃癌患者外周血单个核细胞能在体外有效提呈抗原，激活抗原特异性CTL，诱导特异性抗肿瘤免疫应答。

With the inducing time prolonged, the amount of fusion protein increased, and the highest content amounted to 39. 14% of total protein. Different temperature (15℃, 25℃ and 37℃) could induce expression of fusion protein, and the higher inducing temperature was, the more total fusion protein and soluble fusion protein was produced. Most fusion protein was expressed in the cytoplasm and was soluble, a little of fusion protein was expressed in periplasm or expressed as inclusion bodies, and no fusion protein was found in culture. Furthermore, the results of in vitro enzymatic reaction suggested that the fusion protein could catalyze the methylation of theobromine.

随着诱导时间的延长，表达的融合蛋白产量逐渐增加，表达蛋白总量最高可达到菌体总蛋白的39.14％；在15℃、25℃和37℃三个不同的诱导温度下，均能诱导产生融合蛋白，而且产生的融合蛋白的总量及其可溶性部分所占比例均随诱导温度升高而增加；在菌体的各个部位中，融合蛋白主要在细胞质中以可溶的形式进行表达，有少量在外周质中表达或以包含体形式在细胞质中表达。

In addition to phagocytose pathogens,macrophages can also induce adaptive immunity to perform more specific responses.

巨噬细胞在人体的免疫反应当中扮演著十分重要的角色；其除了能吞噬病原菌之外，还能诱发后天免疫系统，产生更专一的免疫反应。

Phenethyl isothiocyanate also has been shown that to induce cell cycle arrest and apoptosis in many human cancer cell lines, such as human non-small lung cancer cells, prostate cancer PC-3 cells (Prostate cancer metastasized to bone).

另外，也有文献指出苯乙基异硫氰酸酯会造成人类非小细胞肺癌和前列腺癌细胞(PC-3)的凋亡。

Besides, benzyl isothiocyanate and phenethyl isothiocyanate increased caspase-3 activity. Therefore, benzyl isothiocyanate and phenethyl isothiocyanate induce apoptosis in human prostate cancer DU-145 cells.

由此可知，苯甲基异硫氰酸酯和苯乙基异硫氰酸酯会造成人类前列腺癌细胞株DU-145走向凋亡的命运，值得更进一步研究发展为抗癌药物。

Methods: Experimental mice were perfused with different dosages of tetracycline. Eighteen hours later, the serum levels of ALT, AST were measured and the liver tissues were observed by photics microscope to find the relative suitable dosage that can obviously induce acute liver injury. Then the suitable dosage was given in the same way, and the levels of ALT, SOD, MDA, GSH-PS, IL-18 in serum were measured 18, 36, 54, 72 h later respectively. The condition of cell apoptosis was analyzed, and the tissues were observed by photics microscope and electron microscope to find the relative suitable time.

先以不同剂量四环素灌胃，18h后检测小鼠血清ALT、AST水平并进行光镜观察，探索导致明显急性肝损伤的相对合适剂量；再以相对合适剂量四环素灌胃，18、36、54、72h后分别检测小鼠血清ALT、SOD、MDA、GSH-PX、IL-18水平及肝细胞凋亡情况，并进行光镜、电镜观察，探索导致明显急性肝损伤的相对合适时间及可能机制。

At the early stage of HIRBD, the Toll-like receptors may induce NF-kB activation, leading to the coordinated induction of multiple genes, which is involved in inflammatory, apoptosis and cell proliferation. Genes induced by NF-kB are responsible for the physiopathological process of early brain damage in neonatal rats with HIRBD.

在新生大鼠HIRBD早期阶段，主要通过Tlrs诱导NF-kB激活，从而调控下游炎性反应、细胞凋亡及细胞增殖相关基因的表达，参与HIRBD的病理生理过程。

Nowadays, most of research are to build a transmutative Petri Nets through adding controlling place sets, controlling arc sets and controlling policy to the basic Petri Nets, while the Controlled Petri Nets could be used to argue many controlling theory problems conveniently and to induce many logically and physically supervisory and solve the Event Feedback Controlling Problems and State Feedback Controlling Problem in DEDS supervisory theory.

目前大多数的研究表现为在变形后的受控Petri网基础上，利用各种方法求得各种逻辑型、结构型控制器，解决DEDS监控理论中的事件反馈控制问题与状态反馈控制问题。

On one hand, there are discussions with the works council and union about extension of short time working up to the end of September.

一方面，有讨论，工程理事会和联盟关于延长工作时间短至9月底。