查询词典 inactivation

Inactivation of Calcium currents were fitted by two exponential process, which inactivation time constant were over 1000ms and less than 90ms respectively. These properties resembled"L"type and"N"type Calcium currents describled in chick sensory neurons.

用双指数曲线拟合钙电流失活过程，发现它由两种不同的电流成份组成，其失活时间常数分别大于1000ms和小于90ms，它们的特点和鸡背根神经节中"L"型和"N"型钙通道电流相似。

On the basis of the kinetic equation of substrate reaction in the presence of urea or guanidine hydrochloride, all microscopic kinetic constants for the free enzyme and enzyme-substrate binary and ternary complexes have been determined. The results of the present studies indicate that:①In the presence of urea or guanidine hydrochloride, enzyme-substrate complexes lose their activity less rapidly than the free enzyme. Therefore, both substrates, NADPH and 7, 8-dihydrofolate, protect dihydrofolate reductase against inactivation.②The denaturation of dihydrofolate reductase by urea follows single-phase kinetics, and changes in enzyme activity and tertiary structure proceed simultaneously in the unfolding process, so it may be an"all or none"process.③The GdnHCl-induced unfolding of the dihydrofolate shows a biphasic transition, while the change in the enzyme activity is a single exponential process. The rate constant of inactivation is consistent with that of the fast conformational change. Therefore, the kinetic intermediate of protein unfolding should be a partially folded and inactive form.

我们根据在脲或盐酸胍存在下的底物反应动力学方程求得游离酶和酶底物二元、三元复合物的微观动力学常数，结果表明：①酶-底物二元、三元复合物的失活速度明显慢于游离酶，说明两个底物二氢叶酸和NADPH对酶的失活都具有一定程度的保护作用；②在脲作用下，酶的失活和构象变化均为单指数项过程，而且酶的活力丧失和三级结构变化是同时发生的，说明二氢叶酸还原酶的脲变性可能是一个"全或无"的两态过程；③在盐酸胍作用下，酶的构象变化为两相过程，而失活则是单指数项过程，酶分子构象变化的快相速度常数与失活速度常数基本一致，因此我们认为二氢叶酸还原酶的盐酸胍变性过程中存在一个没有活力、但仍具备一定空间结构的变性中间体。

The effects could be attributed to the selective action of BmK Ⅰ on the TTX-S Na〓 channel: slowing the inactivation process of Na〓 channel, increasing the amplitude of peak Na〓 currents; 2 BmK abT, a new-type neurotoxin with higher sequence homology to β-type scorpion neurotoxin, was found to slow the inactivation process of Na〓 channel and prolong the duration of action potential in DRG neurons.

这些结果提示BmK IT2和BmK AS-1的外周抗伤害性效应可能是通过它们对小直径DRG神经元外周游离末梢即C纤维末梢上的TTX-S和TTX-R钠通道的门控调节所致，且BmK IT2对角叉菜胶致炎大鼠较强的抗伤害性作用可能是由于它对TTX-R钠通道较高的敏感性所致。二。特异性钠通道调制剂-东亚钳蝎神经毒素的电生理特征。

Results from whole-cell patch clamp showed: 1 BmK Ⅰ(α-like neurotoxin) was found to prolong the duration of action potential and promote the amplitude of action potential. The effects could be attributed to the selective action of BmK Ⅰ on the TTX-S Na〓 channel: slowing the inactivation process of Na〓 channel, increasing the amplitude of peak Na〓 currents; 2 BmK abT, a new-type neurotoxin with higher sequence homology to β-type scorpion neurotoxin, was found to slow the inactivation process of Na〓 channel and prolong the duration of action potential in DRG neurons.

全细胞膜片钳研究发现：1）类α型哺乳动物毒素BmK Ⅰ可延长部分DRG神经元全细胞动作电位的时程，增加动作电位的幅度，这些效应可归咎于BmK Ⅰ选择性地作用于DRG神经元TTX—S钠通道，延缓TTX—S钠电流的失活化相，峰钠电流幅度增加；2）BmK abT，一个与β型毒素同源性较高的新型蝎毒素可抑制DRG神经元全细胞钠电流失活化过程，使动作电位时程增加。

HupA had no effect on the steady-state inactivation and the recovery of 〓 from inactivation.

HupA使电流衰减过程变得更缓慢，通道不存在完全失活。

It a ears that death is caused by inactivation lf components within the cell through that death is caused by inactivation of components within the cell through energy a orbed within the cell.

看来死亡是由于细胞内部的构成部分因胞内吸收的能量而钝化引起的。

Cell-based infectivity assay indicate pasteurism has shown a little superiority on virus inactivation.The real time PCR technique can be engaged into the evaluation system of virus inactivation and removal thus the risk of blood product containing virus can be reduced.

实验初步显示应用荧光定量PCR技术联合病毒的细胞感染力实验将能够更好的同时检测病毒感染力的变化及病毒含量水平，更全面的评价方法之间的优劣差异，从而进一步降低血液制品的病毒污染风险。

The inactivation efficiencies of spark gap switch pulse source and thyratron pulse source matched with reactors were compared. In addition, the effects of humic acids on both PEF and NTP inactivation were studied. The results revealed that the NTP was more prone to be affected by organic compound.

其次，以饮用水为研究对象，系统的考察了PEF和NTP消毒时，单脉冲能量的影响和连续流条件下的杀菌效果，比较了火花隙开关电源和闸流管开关电源与反应器匹配的杀菌效果，研究了天然水体中存在的腐殖酸对PEF和NTP杀菌效果的影响，结果表明水中的有机物对NTP杀菌的影响很大。

However, the role of inactivation gate of sodium channel is not clear. In present study, single fibre recording in vivo from dorsal root on chronically compressed DRG model was used. We analyzed the characters of ISI series of oscillation firing of type A neurons induced by veratridine, an inhibitor of inactivation gate of sodium channel.

本研究在大鼠背根节慢性压迫模型上，利用在体单纤维记录方法，观察与分析Na通道失活门抑制剂藜芦碱引起受损背根节A类神经元放电ISI序列发生的变化特征，为了解Na通道失活门与放电型式的关系以及进一步探索放电时间型式与疼痛的关系奠定基础。

Inactivation of anterior cingulate cortex and parafascicular or mediodorsal thalamic nuclei, which comprise the medial pain system representing pain affection, substantially impaired this observational fear learning, whereas inactivation of sensory thalamic nuclei had no effect.

前扣带回皮质、束旁或背中部丘脑核组成了代表痛苦感的内侧疼痛系统，一旦失活将会大大损害通过观察习得恐惧感的能力，而感觉丘脑核失活则没有影响。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了