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Methods The present study is a randomized comparative clinical trial. 607 healthy parous women were randomly allocated into GyneFix IN group (n=302) or TCu 380A group (n=305). IUD was inserted during the menstrual interval by the trained investigators. Follow-up were arranged at 1,3,6 and 12 months after insertion. The discontinuation rates were calculated by life table method.

采用随机对比性多中心临床研究方法，对607例健康经产妇女由经过培训的专人以随机方法于月经间期放置GyneFix IN IUD 320例(GyneFix IN组)及TCu 380A IUD 305例(TCu 380A组)，于放器后1、3、6和12个月随访，以生命表法统计两种IUD的终止情况。

In this paper, problems of trend test in clinical experiment are studied mainly by the statistical inference method under order restriction. The ori- gins of order restricted statistical inference are usually dated back to the early 1950s. At about the same time, a number of researchers started working inde- pendently on similar problems. The field developed rapidly during the 1960s and early 1970s and formed the more perfect theory of estimation and test- ing.

中文题名临床试验中的趋势性检验副题名外文题名 Trend test in clinical experiment 论文作者马艳萍导师史宁中教授学科专业概率论与数理统计研究领域\研究方向学位级别博士学位授予单位吉林大学学位授予日期2002 论文页码总数97页关键词临床试验趋势性检验数理统计约束下统计推断馆藏号BSLW /2003 /R311 /1 本文主要利用序约束下的统计推断方法对临床试验中的趋势性检验问题进行了研究。

These solutions will produce in-situ gel formation when transmitted from non-physiological to physiological condition. These polymer systems once instilled in the cul-de-sac will prolong the precorneal resistance time and increase the ocular bioavailability of drugs.

这些溶液由非生理状态转变成生理状态时会产生原位成胶(In-situ gel formation)，因此一旦滴入眼睛穹窿内，可延长药剂在前角膜的滞流时间及强化其眼的生体可用率。

The commercialized liquid ophthalmic formulation is eliminate from the precorneal area immediately upon instillation because of lacrimal secretion and nasolacrimal drainage. This results in very low ocular bioavailability. The problem can be conqurered by in situ gelling system for ophthalmic drug delivery.

一般市面用液体眼药制剂常因滴入眼睛时，受到经常性的泪液分泌及鼻泪管的快速排液，因此呈现很低的生体可用率，此缺点可用原位成胶(In-site gel formation)输送系统来加以改善。

Theshese sole:olutiollns will produce In-situ gel formation when transmltted Tcl from non-physiologlcal to physiologlcal condition. These polymer systems once instilled In the cul-de-sac WIII prolong the precorneal reslstance time and Increase the ocular bloavallabillty of drugs.

这些溶液由非生理状态转变成生理状态时会产生原位成胶(In-stiu gel forma-tion)，因此一旦滴入眼睛穹窿内，可延长药剂在前角膜的滞留时间及强化其眼的生体可用率。

The body breaks down into 7 individualy molded components,these pieces have precut holes in them to allow for appliances to be built in.

身体为7个individualy被铸造的组分在考虑到的他们划分，这些片断有预剪的孔器具被修造in。

Moreover, the dependencies of isotope effect on asymmetric fission and fissioning system size are also studied within the framework of a statistical model modified to include the effects of dissipation in fission by systematically investigating prescission particle evaporation of a light In isotope chain and a medium heavy Er isotope chain.

表明断前粒子发射存在一个同位素效应。进而在一个考虑了裂变过程中摩擦效应的统计模型的框架内，在In和Er这两个元素的同位素链中，考察了同位素效应与裂变碎片质量不对称性和裂变系统尺度的关系。

Excitation functions of neutron, proton and α particle emission prior to scission measured in the reactions 28 Si+ 164,167,170 Er→ 192,195,198 Pb are studied using an extensive fission diffusion model and it is found that the model can well describe the trend of particle multiplicities of Pb isotopes measured experimentally as a function of the bombarding energy,which indicates the existence of isotope effects in prescission particle emission.

用推广的裂变扩散模型研究了2 8Si+16 4，16 7，170 Er→192 ，195，198Pb反应中测量的断前中子、质子和α粒子多重性的激发函数。发现扩散模型能很好地拟合这些轻粒子多重性随裂变系统激发能和Pb同位素的变化趋势。表明断前粒子发射存在一个同位素效应。进而在一个考虑了裂变过程中摩擦效应的统计模型的框架内，在In和Er这两个元素的同位素链中，考察了同位素效应与裂变碎片质量不对称性和裂变系统尺度的关系。计算结果表明：同位素效应的存在不依赖于裂变系统的大小和不对称性。此外，当裂变系统具有高的中质比时，轻带电粒子发射将不再敏感于裂变延迟时间的长短，而中子发射则非常敏感。

In the first stage of alcoholism, the Prodromal Stage, the person drinks in order to escape from reality.

In Late Stage alcoholism， the person 展示一个完整的对酒精的依赖。

Welcome what everybody has fun at to join in the interpreter of Programming In Scala works.

欢迎大家有兴趣的加盟Programming In Scala的翻译工作。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。