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Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome

目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析，并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography，FFA)、吲哚青绿血管造影(indocyanine green angiography，ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例，73.5%)，双眼同时患病118例(80.8%)；后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%)；前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例，98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%)；后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障；毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现；炎症活动期FFA典型表现为斑驳状高荧光，ICGA发现脉络膜血管扩张、通透性增高等改变；VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎，随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。

The effect of tribology factors on bearing vibration is studied experimentally. AR model and WPT are used to processing the normal arid abnormal signals. The results are as follows:1. The vibration of ball bearings is caused by the tribology action of contact pairs of ball and ring races and has the essential of tribo-dynamics. Any factors affecting the tribology characteristics of contact pairs will affect vibration and noise of bearings consequently.2. Vibration characteristics of bearing keep almostly unchanged with the increasing of axial load expecting the increasing of nature frequencies. When radial load increasing with axial load unchanged, nature frequencies keep unchanged but some new vibration peaks appears in the spectrum.3. Vibration amplitudes are damped and nature frequency are enhanced with sufficient lubrication. Vibration and noise of bearings increase obviously and roar can happen and the contact surfaces scratch slightly under insufficient and unclean lubrication state. Bearing will be disabled in a few minutes without any lubrication.4. Bearing vibration is unstable under low speed. With the speed increasing, the vibration become stable and natural frequencies increase slightly but the amplitudes increase apparently.5. Bearing vibration can be excited only by some harmonics ofwaviness without lubrication and by all harmonics with lubrication based on the theoretical analysis.6. The nature frequencies of ball bearings decrease with the increasing sizes. When international clearance increasing, nature frequencies decrease in radial and increase in axial and angular and the amplitudes increase in radial and decrease in axial and angular. When the number of balls increasing, nature frequencies increase and amplitudes decrease. When the pitch diameter increasing, axial nature frequency increase and others nearly keep no change. When outer race groove curvature radius increasing, nature frequencies increase in radial and decrease in axial and angular and amplitudes keep no change in radial and increase in axial and angular. When inner race groove curvature radius increasing, nature frequencies decrease and amplitudes increase.7. The distortion in amplitude and frequency components of bearing vibration signals picked up by the present probe measurement method is founded and right conclusions cannot be achieved by the signals. When accelerometer is rigidly screwed with steel stud onto a flat outer surface of a ball bearing, vibration signal can be got without distortion and the reliability of research on bearing vibration is assured.8. AR model is suitable for large samples of bearing vibration signals, square root of length of samples can be used as the upper limitation of order determination and the FPE order selection criterion is effective. Many advantages of AR spectrum are founded over the classical based on FFT.9. Time-Frequency analysis is necessary for abnormal noise of ball bearings. WPT overcomes the principle shortcomings of STFT and proved to be a best tool to process the abnormal signals.

理论分析和试验研究表明： 1球轴承振动是钢球—滚道接触副中的各种摩擦学作用引起的，具有摩擦动力学的本质，任何对接触副的摩擦学特性有影响的因素都将对球轴承的振动和噪声特性产生影响； 2中心轴向载荷作用下，载荷增大使球轴承的固有振动频率升高，载荷越大同样的载荷增幅引起的频率升幅减小，足够大的中心轴向载荷作用下载荷的变化对球轴承振动的频率特性不会产生明显的影响； 3轴向和径向联合载荷作用下，径向载荷不大时球轴承振动的固有频率基本不变，但是可能引起变刚度激励的非线性振动，出现新的频峰，过大的径向载荷将使部分钢球脱离接触，使球轴承的振动和噪声呈现不稳定状态； 4润滑对球轴承的振动和噪声特性有重要的影响，良好的润滑对振动有明显的抑制作用，润滑不充分时，振动和噪声的水平会有明显增高，一定条件下还会激发接触副中的谐振，发出啸声，造成接触表面的伤害，无润滑干接触时，短时的运转就会损伤接触副表面，使振动和噪声迅速增大，并随时可能引发严重的磨损和卡滞失效；接触副润滑良好时，油膜的"刚化效应"使球轴承振动的固有频率有所提高，润滑剂中含有弥散性污浊时，振动的幅度总体升高，但弥散性污浊不会改变球轴承振动的频率特性；浙江大学博士学位论文：球轴承振动的研究 5低速时，球轴承振动的基本特征呈现不稳定状态，随着转速的提高，球轴承振动的频率特性趋于稳定，固有频率频峰升高； 6理论分析表明，干接触时钢球和滚道表面波纹度的某些谐波分量能激励球轴承的振动，振动的幅值与谐波幅值成正比，实际球轴承中钢球的分布不可能完全均匀，波纹度的激励作用会随时发生；润滑接触的分析表明，波纹度的任意谐波分量均能激励球轴承的振动； 7球轴承的几何和结构参数分析表明，球轴承尺寸越大，径向、轴向和角振动的固有频率越低；钢球中心圆直径增大，球轴承的径向和轴向振动的固有频率基本不变，角振动的固有频率有所上升，振动的幅频特性基本不变；径向游隙加大使球轴承的径向振动固有频率降低，轴向和角振动的固有频率有所升高，径向振动幅频特性的幅值升高，而轴向和角向降低；钢球的数量增多使球轴承振动的固有频率上升，幅频特性的幅值下降，径向振动的幅值下降最为明显；外圈沟曲率半径系数增大使球轴承径向振动的固有频率升高，轴向和角振动的固有频率降低，径向幅频特性基本不变，轴向和角向幅频特性幅值升高；内圈沟曲率半径系数增大使径向、轴向和角振动固有频率均下降，振动幅频特性的幅值均有升高； 8试验对比表明，传感器采用探针式安装时，由于探针接触副接触特性的影响，钡(量得到的球轴承振动信号有失真，采用专门设计和制作的试验球轴承，以固定式安装加速度计，首次测量得到了球轴承振动的真实信号，通过对振动信号的分析，验证了球轴承振动的理论模型； 9)基于时间序列分析的AR模型适用于大样本球轴承振动信号的分析，以样本长度的均方根值作定阶上界，FPE做判阶准则，给出的AR谱光滑，频率分辨率高，是球轴承振动分析的简便而可靠的手段； 10以时频域分析的小波包变换分析球轴承异音信号能够比较好地定位和聚焦异音发生的时间，时间间隔，频率范围，同样是球轴承振动分析的可靠的手段，可用作球轴承故障诊断技术。

In accordance with the Provisions on the Protection of Geographical Indication Products issued by National Bureau of Quality Inspection, by the end of 2009, 21 kinds of products in the province had obtained the protection of national geographical indication products including Zanhuang Chinese Date in Shijiazhuang Area; Shacheng Grape Wine, and Xuanghua Milk Grape in Zhangjiakou Area; Shanzhuang Old Wine, Weichang Potato, Chengde Guoguang Apple in Chengde Area; Changli Grape Wine, Lulong Silk Noddles, and Shimen Walnut in Qinhuangdao Area; Lixian County Chinese Yam, and Rongcheng Bamboo Shoot in Baoding Area; Botou Pear, Cangzhou Golden-Silk Jujube, and Huanghua Winter Dater in Cangzhou Area; Ningjin Pear in Xingtai Area; Shexian County Walnut, Shexian County Pepper, Weixian County Pear, Yongnian Garlic, and Wu'an Millet in Handan Area; and Jingdong Chestnut (including the administration regions of Qianxi, Qian'an and Zunhua in Tangshan Area, Funing, Qinglong, and Lulong in Qinhuangdao Area, Xinglong, Kuangcheng, Pingquan, Chengde, Luanping, and Fengning in Chengde Area).

按照国家质检总局颁布的《地理标志产品保护规定》，截至2009年底，我省石家庄地区赞皇大枣；张家口地区沙城葡萄酒、宣化牛奶葡萄；承德地区山庄老酒、围场马铃薯、承德国光苹果；秦皇岛地区昌黎葡萄酒、卢龙粉丝、石门核桃；保定地区蠡县麻山药、容城绿竹笋；沧州地区泊头鸭梨、沧州金丝小枣、黄骅冬枣；邢台地区宁晋鸭梨；邯郸地区涉县核桃、涉县花椒、魏县鸭梨、永年大蒜、武安小米；京东板栗（唐山地区的迁西、迁安、遵化，秦皇岛地区的抚宁、青龙、卢龙，承德地区的兴隆、宽城、平泉、承德、栾平、丰宁等行政区域）共计21种产品已获得国家地理标志产品保护。

The industry magnesia mainly uses in making the ceramics, the enamel, the fire-proof material and so on; In the polishing compound, the adhesive, in the paint manufacture takes the stopping; In the artificial fiber, the rubber (chloroprene rubber, fluorine rubber) make the promoter and the catalyst; Makes the antacid on the medicine in the laxative, uses in treating the hyperacidity, the stomach and duodenum ulcer; May take the hard sugar purification is the decolorant in the food processing, the ice cream pH value conditioner and so on; In the construction profession, the magnesia may the manufacturing contain the magnesium special cement and the heat preservation board and so on; The biggest use is serves as the fertilizer and domestic animal's feed in the agriculture, causes the plant and in the animal metabolism process principal element, when serves as cow's feed, may prevent because to lack nervous system function being out of balance which the magnesium causes, namely the so-called forage grass convulsion gets sick; Uses in the chemical industry making the metal magnesium and the magnesium chemical, like magnesium sulfate, magnesium chloride as well as other chemicals; Moreover also uses in the water treatment, the detergent which the flue was mad uses in the glass, the dye, the electric cable, the silcon steel industry, the uranium processing, the electronics industry, the insulation material industry, as well as uses in professions and so on petroleum chemical additive, casting, phenolic plastic.

工业氧化镁主要用于制造陶瓷、搪瓷、耐火材料等；在抛光剂、黏合剂、油漆的制造中作为填充料；在人造纤维、橡胶中作促进剂和催化剂；在医药上作抗酸剂于轻泻剂，用于治疗胃酸过多、胃和十二指肠溃疡病；在食品加工上可作为砂糖精制是的脱色剂，冰淇淋的pH值调节剂等；在建筑行业中，氧化镁可生产制造含镁特种水泥和保温板等；在农业上最大用途是用作肥料和牲畜的饲料，使植物和动物代谢过程中的主要元素，用作奶牛的饲料时，可防止因缺镁而引起的神经系统机能失调，即所谓牧草性痉挛病；在化学工业中用于制造金属镁和镁化学品，如硫酸镁、氯化镁以及其他化学品；另外也用于水处理，烟道气的洗涤剂用于玻璃、染料、电缆、硅钢工业、铀加工、电子工业、绝缘材料工业，以及用于石油添加剂、铸造、酚醛塑料等行业。

The selection of geological prospecting in different stages(initial-prospecting, detailed-prospecting)(2)the selection of geological prospecting in the deep-laid and shallow-laid of tunnel project (3)the selection of geological prospecting of tunnel projecting in different geological conditions Finally, the author summed up main problems needing to be solved in tunnel engineering geological prospecting as follow:(1)differentiate stratum and find out the depth and thickness of different stratums in the tunnel section (2)find out geological structure and existence situation of fault, broken zone and weak plane (3)find out weathering level of bed rock to classify surrounding rock combining speed materials (4)differentiate stratum structure of the entrance of tunnel to judge the stability of it (5)find out existence situation and performance of ground water (6)situations of other harmful geological phenomenon In view of above problems and classification of surrounding rock, the author showed principles of rational choosing of methods in geological prospecting and counted disperse range of physical character parameter value in different petrosal character, getting achievements as follow:(1)summarization of effect, merits and demerits of different geological prospecting methods in the tunnel geological investigation (2)method selection and arrangement principle of tunnel engineering geological prospecting in different geological conditions and prospecting stages (3)According to previous experience and cases, the author concluded the物性parameters most in use ,and showed the basis of selecting geological prospecting methods in different geological conditions.

论文中用几个应用实例来说明：(1)不同勘察阶段物探工作的选用；(2)深埋、浅埋隧道工程物探工作的选用；(3)不同地质条件隧道工程物探工作的选用。最后总结归纳出隧道工程物探所需要解决的问题主要有：(1)划分地层，查明隧道通过剖面的各地层深度与厚度。(2)查明地质构造，隧道轴线段有无断层、破碎带、软弱层面等。(3)查明基岩风化程度，从而结合速度资料进行围岩分级。(4)划分洞口地层结构，判断洞口稳定性。(5)查明地下水赋存情况及其活动动态。(6)其他不良地质现象存在情况。针对上述需要查明的地质问题与计算围岩分级情况，论文提出合理选用物探方法的原则，并统计了物性参数值在不同岩性中的分布范围。得出以下研究成果：(1)总结出各物探方法在隧道地质调查中的作用和优缺点。(2)得出不同地质条件下和不同勘察阶段，隧道工程物探方法选择和布置的原则。(3)根据以往工作经验和事例，对常用的物性参数进行了归纳总结，同时介绍了不同地质条件下物探方法选择的依据。

The result shows that: The variation rhythm of the sensitivity index changed unanimously for Jensen,Blank and Stewart water production functions of spring wheat in Liangzhou city,the volume is small in the former stage,then become large at the middle stage,and less at the last stage. Jensen and Stewart water production functions are better of spring wheat in Gulang County in 1987-1989. The Variation rhythm of water deficiency sensitive index is unanimous: the volume are small at first,then large at middle,and diminish at last. The Variation rhythm of water deficiency sensitive index is unanimous in Jensen,Blank and Minhas of flax in Liangzhou county in 1987-1989. The water deficiency sensitive index in Gulang district in 1987-1989 models bad,are too many minus.

结果表明：1985-1986 年凉州春小麦Jensen 模型、Blank 模型和Stewart 模型的敏感指数变化规律接近一致，在前期较小，中期增大，最后再减小。1987-1989 年古浪春小麦水分生产函数以Jensen 模型和Stewart 模型拟合较好，其敏感指数变化规律比较一致，敏感指标值前期较小，中期增大，后期又减小。1983-1985 年凉州亚麻水分生产函数以Jensen 模型、Blank 模型和Minhas 模型敏感指标值变化规律比较一致：先减小，后增大，最后再减小。1987-1989 古浪亚麻敏感指数出现负值较多，模型拟合较差。

The result shows that: The variation rhythm of the sensitivity index changed unanimously for Jensen,Blank and Stewart water production functions of spring wheat in Liangzhou city,the volume is small in the former stage,then become large at the middle stage,and less at the last stage. Jensen and Stewart water production functions are better of spring wheat in Gulang County in 1987-1989. The Variation rhythm of water deficiency sensitive index is unanimous: the volume are small at first,then large at middle,and diminish at last. The Variation rhythm of water deficiency sensitive index is unanimous in Jensen,Blank and Minhas of flax in Liangzhou county in 1987-1989. The water deficiency sensitive index in Gulang district in 1987-1989 models bad,are too many minus. 3 Establishing the non-linear model to definitive the irrigation quota and dimension of single crop,according the three prototype Precipitation,allocating the limited water optimally according to full water supply,95 percent,75 percent and 50 percent. Economy benefit is the biggest aim function,so getting three groups for irrigation quota,irrigation dimension and benefit,the biggest benefit is the most optimal result.

结果表明：1985-1986 年凉州春小麦Jensen 模型、Bl(来源：10a1ABC论文网www.abclunwen.com)ank 模型和Stewart 模型的敏感指数变化规律接近一致，在前期较小，中期增大，最后再减小。1987-1989 年古浪春小麦水分生产函数以Jensen 模型和Stewart 模型拟合较好，其敏感指数变化规律比较一致，敏感指标值前期较小，中期增大，后期又减小。1983-1985 年凉州亚麻水分生产函数以Jensen 模型、Blank 模型和Minhas 模型敏感指标值变化规律比较一致：先减小，后增大，最后再减小。1987-1989 古浪亚麻敏感指数出现负值较多，模型拟合较差。3 建立单作物种植条件下灌溉定额与灌溉面积的确定的非线性规划模型，将有限的水量按照充分供水，95%、75%和50%供水来分配水资源，以经济效益最大为目标函数，得出三组灌区灌溉面积和效益结果，其中以效益最大为最优解。

Results Punctiform erosion, hemorrhage were observed by nake eyes in each groups. Epithelium cellular necrosis, defluxion, neutrophil being dominant in propria lamina and intact glandular were observed with microscopy. The erosion became severe with the successive stimulate of ethanol. There is no difference between distillate spirit and sodium chloride rats in Guth in 7th day, but Guth in distillate spirit rats was higher than that in sodium chloride rats in 30th day. PGE2, TGF-α contents in gastric mucosa of treated group increased significangly compared with control group. PGE2 showed no difference between each group in 7th and 30th day; TGF-α in gastric mucosa of distillate spirit and sodium chloride rats decreased after 1 month.

结果 茅台组、乙醇组、生理盐水组胃黏膜均肉眼可见程度不同的点状糜烂、出血；光镜下黏膜部分上皮坏死脱落，固有层以中性粒细胞为主炎性细胞浸润，腺体结构基本完整，病变随时间延长有所加重，Guth积分1周茅台组与生理盐水组差异无统计学意义，1月两者相比差异有统计学意义；茅台组、乙醇组胃黏膜组织内PGE2水平与生理盐水组相比明显增高，同时TGF-α表达增强；但PGE2水平各组间1周与1月相比差异无统计学意义；TGF-α表达强度在茅台组、生理盐水组1月后逐渐降低，差异有统计学意义。

Results the basic CT features of 102 patients with Peripheral lung adenocarcinomas were as follows:vacuole or air bronchogra charging sign was found in which as were seen in 24 cases (80%) in high differential adenocarcinoma and were seen in 10 cases (30.3%) in moderate differential adenocarcinoma but not seen in low differential ones, spiculation sign in 73(71.5%). spiculate protulerance sign in 52 (50.9%). lobulation sign in 79(77.4%), pleural in dentation sign in 65(63.7%), vessel convergenoe sign in 69 cases(67.6%), and calcification inside the lesion was 31 cases. 67 cases had more then three basic CT signs mentioned above.

结果 102例周围型肺腺癌的主要CT分析征象是：空气支气管征或空泡征、高分化腺癌24例（80％）、中分化腺癌10例（30.3％）、低分化腺癌无此征、毛刺征73例、棘突征52例、分叶征79例、胸膜凹陷征65例、血管集束征69例、病灶内钙化31例，其中67例出现上述三种以上征象。

The CPT values in the affected leg in patient group were significant higher than those in control group at all frequencies. The CPT values in contralateral leg in patient group were significant higher than those in control group at 5Hz whereas there were no significant differences at 250Hz and 2000Hz. The CPT values in affected leg in patient group were significant higher than those in contralateral leg at 250Hz and 2000Hz whereas there were no significant differences at 5Hz. All the CPT values showed the same linear decrease from the dermatome of the compressed root to the dermatomes of the contralateral neighbor dematom.

在用CPT监测8例腰骶单神经根病组患侧和健侧及与正常对照组的不同直径感觉神经纤维功能的研究中发现压迫皮节和其临近皮节的所有频率CPT值无任何显著性差别；患者压迫侧的2000Hz及250HzCPT值及压迫侧和对侧的5HzCPT值与正常对照组都有显著性差别；患者组5HzCPT值患侧和对侧无差别，其他两组均有显著性差别；不管有无显著性差别，神经根病患者组各皮节三频率CPT值均按照压迫皮节，临近皮节，压迫对侧皮节，压迫对侧临近皮节的顺序减小，说明在腰骶单神经根病中Aβ纤维及Aδ纤维及无髓C纤维均受累。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。