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In order to understand the drug resistance mechanism of HIV-1 integrase mutually existed for multiple drug-resistant strains to the most potent IN inhibitors diketo acids, three S-1360-resistant HIV-1 strains were selected and molecular docking and molecular dynamics simulations were performed to obtain the inhibitor binding modes.

为了解DKAs引起的多种耐药株共有的耐药性机理，选择3种S-1360引起的IN耐药突变体，用分子对接和分子动力学模拟，研究了野生型和突变型IN与S-1360的结合模式，基于该结合模式探讨了3种耐药突变体所共有的耐药性机理。

The barley chromosome in wheat was identified by genomic in situ hybridization in which biotin labelled total genomic DNA of barley betzes was used as probe and the unlabelled total DNA of common wheat Chinese Spring as blocking DNA. A series of wheat materials were tested as follows; two disomic alien substitution and monosomic alien addition lines, 2n=43; two monosomic alien substitution lines.

用生物素(Biotin-16-dUTP)标记的大麦Betzes基因组DNA作探针，以普通小麦中国春总DNA作封阻进行基因组原位杂交(Genome in situ hybridiz ation，简称GISH)，从13株小麦-大麦杂交后代中鉴定出2个含有3条大麦B etzes2H染色体的材料(2n=43)；2个2H单体异代换系(2n=42)；7个2H二体异代换系(2n=42)。

The novel restorer line Nsa restorer-1 and its progenies were analysed by genomic in situ hybridization combined with double-colour fluorescence in situ hybridization technologies, the results showed that Nsa restorer-1 was Brassica napus-Xinjiang wild Sinapis arvensis disomic alien addition line,consisting of the whole genome of Brassica napus and a homologous chromosome pair of Xinjiang wild Sinapis arvensis.

用基因组原位杂交(genomic in situ hybridization， GISH)结合双色荧光原位杂交(double-colour fluorescence in situ hybridization， dc-FISH)技术，对甘蓝型油菜新型恢复系Nsa恢1及其后代进行了研究，结果表明，Nsa恢1为甘蓝型油菜-新疆野生油菜二体异附加系，包含了甘蓝型油菜全基因组和新疆野生油菜1对染色体，这1对新疆野生油菜染色体为同源染色体。

Generally, most of the follicles undergo atresia during their development in mammals, and only a few grow to maturation and ovulation. For many years, the mechanisms of follicular atresia have been one of the foci of study. Recently, with the development in studies on cell apoptosis, it has been proved that follicular atresia is a process of cell apoptosis. However, the endocrinological and molecular evens underlying follicular development and atresia and granulosa cell apoptosis in the goat has not been studied.

中文题名山羊卵泡发育、闭锁及其调控机理的研究副题名外文题名 Studies on follicular development and atresia and their regulatory mechanism in goat 论文作者于元松导师谭景和教授学科专业基础兽医学研究领域\研究方向动物胚胎学与胚胎生物工程学位级别博士学位授予单位东北农业大学学位授予日期2002 论文页码总数71页关键词山羊卵泡发育馆藏号BSLW /2003 /S827 /3 哺乳动物卵泡在发育过程中绝大多数闭锁退化，只有少数卵泡发育成熟至排卵。

On the silicon substrate an epitomical layer is made,where IC components are formed subsequently.In an CVDprocess,the silicon substrates places in a vacuum crystal tube are first heated to 1,600°C by high-frequency radio power and then H⒉Cl⒉Si and certain gaseous compounds of As or P is injected into the tube to make a deposit of several um on their surface.Ions of As or P are impurity deliberately added to the singl-crystalline silicon structure to supply electrons that transmit "negative"current in the silicon crystals,which is called n-type silicon.Bcan be added as impurity to produce p-type silicon that supplies holes for transmitting "positive"current.Whether a p--type of an n-type silicon substrate is needed depends on what type of transistors is expected to be manufactured on it:n-p-n type of p-n-p type

对硅衬底上的一个epitomical层了，而IC零件形成subsequently.in一个CVD法（化学气相depsition ）过程中，硅衬底的地方在真空晶体管均先加热至1600 ° C时，由高频率的无线电功率，并然后h ⒉氯⒉硅和某些气态的化合物，砷或P ，是注入试管，使存款的几位嗯对他们surface.ions的作为或P是杂质刻意添加到单结晶硅的结构，以供应电子传递的&负面&目前，在硅晶体，即所谓N型silicon.b ，可以增加一条，作为杂质产生的p型硅供应孔转递&积极& current.whether一个P -类型的一个n型硅衬底，是需要靠哪些类型的晶体管预计将在制造上它： NPN型的PNP型

At 14 years old, she was invited to perform in front of Warner Records executives who were so impressed at her a cappella rendition of Aretha Franklin 's "If You Lose a Good Thing" that they signed her on the spot. After guesting on "The Harder They Come," a track from Paul Oakenfold 's Bunkka album, and supporting Mis-Teeq on their U.K. tour, White released her debut single,"Watcha Gonna Do," in 2004. Follow-up "Don't Care Who Knows," a duet with U.S.

她继承了母亲最优秀的歌唱基因，曾为知名艺人Black Eyed Peas和Lemar等人做过暖场，首支单曲《Watcha Gonna Do》在UK榜上排在第75名。2005年3月7日，凭借首张专辑《Seventeen》震惊英国音乐界后，便成为数家唱片公司争夺的才女。2006年2月27日，发行的《The Weakness In Me》是她迄今为止成绩最好的一首单曲。

Here we also converted Hubba into cytoHubba, a Cytoscape Plug-in for Hub Object Analysis in Network Biology

为了利用Cytoscape 的辅助与其软体能见度，与cytoscape 平台其他plug-in 的协助，我们将hubba 变成cytoscape 的一个分析模组，称为cytoHubba，得以提供更多生物学家对庞大的基因网路，采取更精辟、便利的分析，进而提升生物网路分析的准确度。

The data collected from in vitro and in sacco digestive trials showed that suplementing BYC can significantly increate fiber digestibility.

In sacco及In vitro的消化试验均表明，BYC对饲料粗纤维素的消化率均有极显著的(p.01)促进作用。

In conclusion, the author puts forward a new linguistic term-"Bilingual Interference in Interlingual Error".

在结论部分，作者依据学生所犯错误的特征，创见性地提出了&BilingualInteri触renee in Interlingual Ermr&这一术语。

What role does the support arm of an intraoral X-ray unit play and how is this problem solved in In eXam?

口内X光设备的支撑臂起什么作用，In eXam中如何解决此问题？

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。