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For normal mouse, Yi Shen Granule could prolong the swimming time of mouse, the survival in Yi Shen Granule groups was more than that in model control group in same cold condition. For low-immune mouse, The eliminated rate of carbon granule in Yi Shen Granule groups rats was faster than that in model control group rats, it showed that phagocytosis was boosted up, the absorbency of upside liquid in Yi Shen Granule groups rats was more than that in model control group rats in hemolysin mensurated test, it indicated that more antibody was come into being by giving Yi Shen Granule.

益肾颗粒可以延长小鼠游泳时间；增加在同一寒冷条件下，相同时间内小鼠的存活数；对免疫力低下小鼠，给药组动物的碳粒廓清指数增大，反映吞噬功能增强；在血清溶血素含量测定试验中，给药组动物的上清液吸收值增大，说明机体产生的抗体较多。

①Location of WD gene in Ch inese: Using pairwise linkage analysis and multipoint linkage analysis method, w e constructed a genetic map of DNA markers within D13q14.2-3 which refined the location of WD gene by restriction fragment length polymorphism and microsatellite polymorphism analysis;②Screen for mutations of WD gene in Chinese people: we detected the structure of 21 exons of WD ge ne in 45 patients from 39 pedigrees by PCR-SSCP(Single strand conformation poly morphism) and PCR-DNA sequencing technology, found a new mutation in exon 5 and nuclcotide sequence analysis showed it is a T insertion. We also conformed the Arg778Leu in exon 8, the highest frequence mutation point in Chinese people, wit h mutation rate 22.8%in total;③Carrier detection and presymptomatic diagnosi s of WD: Based on DNA recombination technology, we peformed successfully the gen e diagnosis in all individuals of 79 families with WD and built up a helpful spe cific enzyme cut method (PCR-Msp1) to detect the carrier and presympomatic patients in Chinese pe ople with WD.

①WD的基因定位研究：通过RFLP及微卫星多态性分析，应用两位点及多位点连锁软件，建立了中国人WD基因在D13q14.2-3区域的精细遗传连锁图谱，从而首次对中国人WD基因进行了精确定位；②WD基因突变研究：应用PCR-SSCP及DNA测序技术，对39个家系45名WD患者进行该致病基因的21个外显子突变筛选，发现WD基因5号外显子存在新的T插入突变，并证实中国人WD基因的突变热点为8号外显子，突变形式为Arg778Leu，其频率为22.8%；③WD的症状前诊断和杂合子检出：应用DNA重组技术对79个家系进行基因诊断，成功地进行了WD的症状前诊断和杂合子检出，并建立了WD的基因筛选的PCR-Msp 1酶切方法。

With the fast development of economic construction of our country, the safety accident in production is outstanding day by day too, the question of safety in production receives the extensive concerns of the country , government and society more and more, directly subordinate organ as the government sets up the mechanism of safety in production rapidly in the whole country, the safety in production has been laid out the government"s important agenda, but as to new organization of safety in production, difficulty and pressure , opportunity and challenge faced are a lot, how to put the thinking in order in work of thousands of strands and loose ends, catch the focal point, give full play to the role of the government"s supervision and management, turn back the passive state of the safety in production rapidly, it is the focal point that this text discusses.

随着我国经济建设的快速发展，安全生产事故也日益突出，安全生产问题越来越受到国家、政府和社会的广泛关注，安全生产机构作为政府的直属机构在全国迅速建立起来，安全生产工作摆上了政府的重要议事日程，但就新的安全生产机构来说，面临的困难和压力、机遇与挑战是很多的，在千头万绪的工作中如何理清思路，抓住重点，充分发挥政府的监督管理作用，迅速扭转安全生产工作的被动局面，是本文讨论的重点。

For example, HLA associations with vitiligo include HLA-DR4 in Caucasian Americans, DR4 and DQW3 in black Americans, DR4 and DR6 in a Dutch caucasoid population, DR7 and DQW3 in north Italians, DR7 in Omanis, DR1 in Hungarians, DRW12 in north Germans, and DW7 in Slovakians. Negative association of DR1, DR3 and DR52 were observed in north Italians. With the DNA typing of HLA, it was found the frequencies of HLA-DRB1〓0701, DQB1〓0201, DPB1〓1601 alleles were significantly increased in Slovak patients and DRB4〓0101 were increased in Dutch patients.

此后发现美国黑人与DR4、DQW3明显相关；匈牙利、德国和斯洛伐克患者中，HLA-DR1、DRW12和DW7抗原频率分别升高；HLA-DR7与意大利患者明显相关，而DR1、DR3则明显降低；荷兰患者中HLA-DR4和DR6抗原频率明显升高，而DR3明显降低；HLA-DR7与阿曼人明显相关，而肢端型又较局限型明显升高。90年代后，DNA分型法用于HLA的研究，发现斯洛伐克患者与HLA-DRB1〓0701、DQB1〓0201、DPB1〓1601明显相关；荷兰患者的DRB1〓0400，〓0901，〓1300、DRB4〓0101、DQA1〓0301、DQB1〓0302，〓0303基因频率升高，而DRB1〓1100、DQA1〓0501降低，但经校正后，仅DRB4〓0101有显著意义。

This "culture of struggle" is being institutionalized in diverse ways, some at quite early stages, others quite developed: in films; in music (the union launched an album that included both traditional labour songs and songs specifically written about the recent events); in art (the new educational center has permanent exhibits and will host temporary exhibits celebrating solidarity and internationalism); in the unique level of resources now dedicated to both education and communicating with the membership (the new education center, the expansion of materials and pamphlets, the growth in the core of locally-based educators, the strengthening and expansion of local union papers); in the mood, style, and content at the Canadian Council, Conventions, and other union meetings; and, of course, in the on-going struggles themselves in collective bargaining and - as with free trade - politically.

这种"文化斗争"制度化正在以各种方式，有的还相当早期阶段，其他相当发达：在电影；音乐（联盟发起了一个专辑，其中包括传统的劳动歌曲和音乐专门写最近发生的事件）；在艺术（新的教育中心，永久展览和临时展览将举办庆祝团结和国际主义）；中的独特的资源水平，现在专门的教育和沟通的成员（新的教育中心，扩大材料和小册子，增长中的核心，当地的教育工作者，加强和扩大当地联盟篇）；人的情绪，风格和内容在加拿大，公约和其他联盟会议；和当然，在正在进行的斗争本身在集体谈判和-与自由贸易-政治。

Results We found GM1 antibody in 36% and cephalin antibody in 43% of MS patients in serum,GM1 antibody in 11% and cephalin antibody 18% in cerebrospinal fluid.The levels of antibody in serum of treated_MS patients were significantly lower than those in active MS patients.The levels of myelin basic protein in serum and cerebrospinal fluid in MS were significantly higher than those in control group.

结果 多发性硬化患者血清GM1抗体阳性率 36%，脑磷脂抗体为43%；脑脊液GM1抗体为11%，脑磷脂抗体为18%，与对照组比较差异均有显著性；血清和脑脊液的髓鞘碱性蛋白增高亦有意义。

The first part consists of three experiments:(1) The rings were incubated in KH, 20, 50 mmol/L 〓 for 1 house, relaxation in response to the EDHF stimuli A23187 in 30nmol/L U46619-induced preconrtaction in the presence of 7 μ mol/L indomethacin, a cyclooxygenase inhibitor, 300μmol/L LNNA, a nitric oxide biosyhnthesis inhibitor, and 1mmol/L tetraethylammonium , a 〓 blocker, or 3 μmol/L glibenclamide , a 〓 blocker, was compared with the control;(2) After the arteries were incubated in KH, UW solution or HTK solution at 4℃ for 4 hours, endothelium-derived relaxation (percentage of 30nmol/L U46619 precontraction) was induced by A23187 in the present of 7 μmol/L indomethacir and 300μmol/L LNNA;(3) After incubation with KH, UW solution and STH (either at 37℃ in oxygenated organ chamber or at 4℃ in a refrigerator for 4 hours), endothelium-derived relaxation (percentage of 30nmol/L U46619 precontraction) was induced by A23187 in the present of 7 μ mol/L indomethacin and 300 μmol/L LNNA.

第一部分研究结果：（1）单纯浸泡于KH的冠状动脉A23187能引发66.67％的血管舒张反应，经TEA及20mmol／L、50mmol／L钾离子作用后，血管舒张反应程度显著降低，但经GBM作用后改变不明显；（2）与保存于KH的冠状动脉相比，A23187引发的血管舒张反应程度，保存于UW液的明显下降，保存于HTK液的无明显变化；（3）在37℃条件下，血管环浸泡于STH出现缓慢轻微的舒张反应，浸泡于UW液初期出现短暂收缩反应，但此后主要以舒张为主：在37℃条件下，血管经UW液保存后，U46619引发的收缩反应程度降低；不论在37℃或4℃条件下，A23187引发的血管舒张反应，经UW液保存后明显下降，但用STH保存后变化不明显。

Results MRI of all WE patients showed symmetrical high signals on the brain T2WI, Flair and diffusion weighted imaging, 6 cases of them in the medial thalamus, 4 cases in surrounding the aqueduct, 3 cases in the third ventricle gray matter, 2 cases in the mamillary bodies, 1 case in the putamen,1 case in the optic chiasm, 1 case in the superior cerebella vermis and 1 case in the subcortical white matter; 2 cases had reinforcement effect. 2 cases showed no abnormal signals on T2WI and Flair early, but showed high signal symmetrically in the medial thalamus on DWI imaging.

结果 8例WE患者MRI示脑部T2WI、Flair成像及弥散加权成像有对称性异常高信号影，其中出现在丘脑内侧6例、中脑导水管周围灰质4例、第三脑室周围灰质3例、乳头体2例及壳核、视交叉、小脑上蚓部、皮质下白质各1例；2例有增强效应。2例发病早期T2WI、Flair无异常信号影，DWI示丘脑内侧对称性异常高信号影。

Resulte: In 12 infective lesions, including purulent infection (4 cases) and tuberculosis (8 cases), the correct dignosis was made in 4cases by CR and in 11 cases by CT. In 16 soft tissue tumors, including lipoma (7 cases), fibrosarcoma (4 cases), hemangioma (1 case), neurofibroma (1 case), malignant fibrous histocytoma (1case), aggressive fibromatosis (1 case) and liposarcoma (1 case), the correct diagnosis was made in 3cases by CR and in 14 cases by CT. In 11 bone lesions, including fibrous dysplasia (7 cases), chondroma (2 cases), myeloma and cosinophilic granuloma (1 case), the correct diagnosis was made in 8cases by CR and in 10 cases by CT.

结果：感染组12例中(包括化脓性感染4例，胸壁结核8例)，CR准确诊断4例，CT诊断11例；软组织肿瘤组16例中(包括脂肪瘤7例，纤维肉瘤4例，血管瘤、神经纤维瘤、恶性纤维组织细胞瘤、侵袭性纤维瘤病和脂肪肉瘤各l例)，CR准确诊断3例，CT诊断14例；骨肿瘤和肿瘤样病变组11例中(包括骨纤维异常增殖症7例，软骨瘤2例，多发性骨髓瘤和骨嗜酸性肉芽肿各1例)，CR准确诊断8例，CT诊断10例。

Four potential exploration targets are: Drape and extruding anticline traps in the source rock drainage area in Chonta Formation in central-western basin; Traction and extruding anticline traps in the source rock drainage area in Pucara Group in central-southern basin; Pucara Group carbonate traps in central basin; Upper Cretaceous lithologic traps and Upper Paleozoic structural-stratigraphy traps in the northern and eastern exploratory area.

有潜力的勘探领域包括中西部白垩系Chonta组烃源岩供油区域的披覆和挤压背斜圈闭，中部和南部侏罗系Pucara群烃源岩供油区域的牵引背斜圈闭和挤压背斜圈闭，中部的Pucara群碳酸盐岩圈闭，北部和东部成熟探区上白垩统岩性圈闭和上古生界构造-地层圈闭。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐