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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, at LARM in Cassino, most of the work in the field of robotics has been and is carried out to gain experience and investigate robotic systems with a low-cost robot design approach.

总之,在LARM在Cassino,大多数工作在领域的机器人学和被执行获取经验,并且调查机器人系统以一个便宜的机器人设计接近。

The author also brings his proposal about how to perfect the legislation of common bribery. He suggests: Firstly, in the general principles of criminal law, it should be prescribed definitely no matter the person who has identity or not committing a crime together which is constituted for their identity, the action belongs to common crime. Secondly, in separate principles of criminal law, the spirit of rule about the common bribery crime in "The conversazione summary of country court cognizance economy crime cases" put out by the supreme court of people in 2003 as well as "The notions of some questions about the suitable laws of transacting the bribery case in the supreme court of people and the supreme procurator of people" in 2007 should be put in the separate principles.

对如何完善共同受贿立法作者提出了自己的建议:建议在刑法总则中明确规定,无身份犯与身份犯勾结,共同实施因犯罪人身份而构成的犯罪,属共同犯罪,在分则中把2003年最高人民法院《全国法院审理经济犯罪案件工作座谈会纪要》以及2007年《最高人民法院最高人民检察院关于办理受贿刑事案件适用法律若干问题的意见》关于受贿罪共犯的规定精神纳入,分则中385条可以增加两款:与国家工作人员勾结伙同受贿的,以受贿论处。

In summary, age-related changes of GABA metabolism and dendrite on rat visual cortex were observed in the present study.

大鼠初级视皮层神经元的GABA分布、代谢具有明显的年龄相关性的变化。

In summary, they are the challenges of evangelization in the modern context and more specifically in a strongly Muslim environment.

总括来说,在现今的世代,尤其是在浓厚伊斯兰气氛的环境中,都带来很多挑战。

The dramatist and musical characters and the perfect combine between music and drama are the purports. The thesis is divided into three parts: the preface, four chapters and the conclusion. In the preface it is explained that what in this thesis is expounded and what kinds of study about the opera there are in Chinese and in the other area of the world. The first chapter is a summary about Gounod and his"Faust", which is the typical work in lyric operas. In the second chapter analysis on drama, the character and figures of the roles in the opera is made, and the characteristic of the plot ,the creation of opera and framework is put together. In the third chapter the music in the opera is studied, and the characteristics are put together on the base of particular analysis on typical passage of aria chorus ensemble. In the last chapter, perfect combine between drama and music is presented by study on Faust's character and psychology,and it is discussed that music implied the plot. And the conclusion is a whole comment of the opera and it's musical characteristics

更多论述。全文由引言、四个章节、结论等几个部分组成:引言是关于论文的选题、国内外研究现状的陈述,指明笔者选题的意义以及国内外学者对此课题的研究程度;第一章是对抒情歌剧作曲家古诺以及抒情歌剧的典范之作《浮士德》的一个总体上的概述;第二章从人物性格与戏剧情节、戏剧结构、戏剧创作等方面对歌剧《浮士德》进行分析,归纳其戏剧特点;第三章是对歌剧《浮士德》音乐特点的研究,通过对咏叹调类、重唱类、合唱类唱段中有代表性唱段的具体分析,总结其在音乐创作方面的主要特点;第四章从音乐刻画人物的性格与心理、音乐暗示戏剧情节的发展等方面,论述了歌剧《浮士德》在戏剧与音乐方面的完美结合;结论是对歌剧《浮士德》的整体论析。

SUMMARY In 21 century, all corporations in the world compete and develop in an environment of more merciful and uncertain and murkiness. Theory of strategy management and a lot of corporations sample thoroughly prove that a corporation lack of strategy just as a plane in bad weather, which will lose its direction probably.

进入21世纪以来,各个企业越来越在动荡、多变、不确定和混沌的环境中运作、竞争,战略管理理论和大量实践证明一个没有战略的企业,如同在险恶气候中飞行的飞机,随时可能迷失方向。

Adds summary descriptions of types, members, and parameters to IntelliSense ToolTips in code and in the Object Browser for Microsoft Office Word, Microsoft Office Excel, Microsoft Office Outlook, and Microsoft Office Shared PIAs in Microsoft Visual Studio .

它会自动识别在 Word 2002 及 Excel 2002 文件中台湾的股票名称及代码(如台泥,台湾水泥,1101),并自动更新股票名称和代码清单,及提供相对应的快速操作,如提供该股的股市报价、公司报表、最近新闻、基本资料及汇入可更新的股票资料等。

SUMMARY: Automatic detection of respiratory variations in pulse oximetry plethysmographic waveform amplitude can predict fluid responsiveness in the operating room in patients under mechanical ventilation and has potential for fluid optimization in this setting.

概要:自动检测呼吸变化的脉搏血氧仪体积描记波幅可以预测手术室机械通气患者的流体应答,并且此设备有潜在的流体优化功能。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。