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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle,CP)和两个19S调节颗粒(regulatory particle,RP)组成的ATP(adenosine-triphosphate,ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心,它是由4个圆环堆叠形成的桶状复合物,其中两侧外环每个环是由α_1-α_7亚基组成,两个内环每个环是由β_1-β_7亚基组成,4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔,其内壁为催化活性位点所在地;外侧α环中心的孔道是底物到达催化中心空腔的通道,一般被α亚基上的N末端所封闭,阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

In the coming days, it grows and bends into the shape of the heart.

在接下来的日子里,它不停的成长、弯曲,形成了心脏最终的形状。

In the coming days, it grows and bends into the shape of a the heart.

在接下来的日子,它开始生长弯曲成心脏的形状。

In the coming days , it is the growth grows and benth bends into the shape of the heart.

在以后的日子里,它生长并弯曲成心脏的样子。

In the coming days , it grows and bands bends into the shape of the heart.

接下来的日子里,它生长并且弯曲成心脏的形状。

The shape of the electron spectrum in beta decay is not dominated by properties of the matrix element.

衰变的电子谱的形状不取决于矩阵元的性质。

The light distributions in an erythrocyte with the shape of native biconcave,oblate spheroid,or disk sphere under the irradiation of a plane light of 632.8nm were studied with a numerical calculation method of finite difference time domain.

我们用有限时域差分的数值计算方法来研究用632.8nm平面光波照射双凹型,扁球体型或圆盘球体型红细胞后在红细胞内部产生的光分布。

According to the comparative research on Guangnania, the diagnosis of the zosterophytes is expanded. It is suggested that their sporangia have the differentiation in the shape (reniform, rounded/globose to vertically elongate), dehiscence and valves (biconvex or concave/convex).

根据Guangnania的研究和对比,对工蕨类植物的特征进行了扩展,认为孢子囊存在形状(肾形—圆形/球形—纵向伸长)、开裂方式和两瓣的分异。2。

What the lysine does, Dougherty and colleagues report online this week in Nature, is change the shape of the brain receptor's box, effectively making its negative charge more accessible to nicotine--a situation known as a cation-pi interaction.

Dougherty 他们在这个星期的 Nature 网站上报道说,它能够改变大脑受体"口袋"的形状,有效地使其负电荷更好与尼古丁相作用,就是所谓的阳离子—π作用( a cation-pi interaction )。

The sensitivity analysis which is based on the calculus of variations is used in the shape optimization. The design velocity field is solved by Herrmann method. An example shows that both the quality of the FEM mesh and the efficiency of the computing of the design velocity field are improved by Herrmann method.

算例表明优化过程中采用Herrmann网格均匀化法求解设计速度场,可以提高优化过程中网格的质量,速度场的求解效率也得到极大的提高从而优化的效果和效率都有明显提高。

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推荐网络例句

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了,排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意,我建议我们在价格上大家各让一半。

After an hour and no pup, look for continued contractions and arching of the back with no pup as a sign of trouble.

一个小时后,并没有任何的PUP ,寻找继续收缩和拱的背面没有任何的PUP作为一个注册的麻烦。