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From the calculations, it can be found that the van der Waals interactions, the hydrophobic interactions, as well as the H-bonding interactions are crucial for the ligand binding. The 4-phenylamino group can produce strong van der Waals adn hydrophobic interactions with the nonpolar side chains of the residues deep in the binding cleft. The R^1 and R^2 substituents on the bicyclic chromophore can also produce strong van der Waals and hydrophobic interactions with the residues located at the exterior part of the binding pocket. Moreover, the two N atoms of the quinazoline can form H-bonds with EGFR, which will produce significant contribution to biological activities. The calculated nonbonded interactions between anilinoquinazolines and EGFR, as well as the information obtained from the predicted complexes, can interpret the structure-activities of the inhibitors well, which can afford us important information for structure-based drug design.

从模拟结果得到的抑制剂和靶酶之间的相互作用模式表明范德华相互作用、疏水相互作用以及氢键相互作用对抑制剂的活性都有重要的影响，抑制剂的苯胺部分位于活性口袋的底部，能够与受体残基的非极性侧链产生很强的范德华和疏水相互作用，抑制剂双环上的取代基团也能和活性口袋外部的部分残基形成一定的范德华和疏水性相互作用，而抑制剂喹唑啉环上的氮原子能和周围的残基形成较强的氢键相互作用，对抑制剂的活性有较大的影响，计算得到抑制剂和靶酶之间的非键相互作用能以及抑制剂和靶酶之间的相互作用信息能够很好地解释抑制剂活性和结构的关系，为全新抑制剂的设计提供了重要的结构信息。

Rosiglitazone can decrease the expression of RBP4mRNA in 3T3-L1adipocyte that used dexamethasone induced into insulin resistance model, and can improve the expression of GLUT4mRNA. 3. Rosiglitazone can increase the glucose intake in 3T3-L1 adipocyte. Chapter 2 Superficial Observed the Expression of Rebinding Protein 4 in OLETF rats OBJECTIVE Compare the level of the expression RBP4 between OLETF rats and LETO rats in adipose tissue; observe the function that rosiglitazone interfere in the expression of RBP4; observe the relationship between RBP4 and GLUT4, then approach the possible mechanism that RBP4 induce to insulin resistance.

第二章罗格列酮对OLETF鼠RBP4的影响，以及RBP4在OLETF鼠内脏脂肪表达的初步观察比较自发性2型糖尿病OLETF鼠与同家系LETO鼠脂肪组织视黄醇结合蛋白(RBP4)水平；观察罗格列酮对RBP4的干预作用；观察脂肪组织RBP4与GLUT4水平的相关性，从而探讨RBP4导致胰岛素抵抗的可能机制。

Polymethyl methacrylate is the most used filling materials at present; There is not significant difference between unipedicular and bipedicular vertebroplasty; Using vertebral body venography and appropriate dense bone cement can reduce leakage of bone cement; Bolster for self-replacement can rebound vertebral body height, and balloon kyphoplasty and sky bone expander kyphoplasty can be avoided; In order to reduce refracture of vertebral body, anti-osteoporosis drugs should be used in the treatment of percutaneous vertebroplasty.

聚甲基丙烯酸甲酯是目前最常用的填充物；单侧注射和双侧注射疗效没有明显差别；应用对比剂及掌握合适的骨水泥黏稠度可以减少骨水泥的渗漏率；成形前腰部垫枕自身复位可以恢复椎体的高度，避免采用操作复杂及价格昂贵的球囊后凸成形及骨膨胀椎体后凸成形；进行经皮椎体成形时应该配合应用抗骨质疏松药物，以减少椎体再骨折的发生。

The farmer can work alone in the field or the woods all day, hoeing or chopping, and not feel lonesome, because he is employed; but when he comes home at night he cannot sit down in a room alone, at the mercy of his thoughts, but must be where he can :see the folks,: and recreate, and, as he thinks, remunerate himself for his day's solitude; and hence he wonders how the student can sit alone in the house all night and most of the day without ennui and :the blues:; but he does not realize that the student, though in the house, is still at work in his field, and chopping in his woods, as the farmer in his, and in turn seeks the same recreation and society that the latter does, though it may be a more condensed form of it.

农民能在田间整天的劳作，除草或者耕作，不会感到孤独，因为他专心于工作。但是日落而归后他不能忍受独守空房，任由思想支配，但是他必须到能看到他伙伴的地方，调整疲惫的身体，就如他所想的回补白天的孤独；由此他想知道那些学生如何能整晚的坐在房间里，不知疲倦和抑郁。其实是他没有意识到那些学生即使在房间也在他的田间工作，就如农民一样，他也在寻找同样的快乐和同伴，只是他的形式更简单罢了。

The farmer can work alone in the field or the woods all day, hoeing or chopping, and not feel lonesome, because he is employed; but when he comes home at night he cannot sit down in a room alone, at the mercy of his thoughts, but must be where he can "see the folks," and recreate, and, as he thinks, remunerate himself for his day's solitude; and hence he wonders how the student can sit alone in the house all night and most of the day without ennui and "the blues"; but he does not realize that the student, though in the house, is still at work in his field, and chopping in his woods, as the farmer in his, and in turn seeks the same recreation and society that the latter does,though it may be a more condensed form of it.

农夫可以一整天，独个儿地在田地上，在森林中工作，耕地或砍伐，却不觉得寂寞，因为他有工作；可是到晚上，他回到家里，却不能独自在室内沉思，而必须到"看得见他那里的人"的地方去消遣一下，用他的想法，是用以补偿他一天的寂寞；因此他很奇怪，为什么学生们能整日整夜坐在室内不觉得无聊与"忧郁"；可是他不明白虽然学生在室内，却在他的田地上工作，在他的森林中采伐，像农夫在田地或森林中一样，过后学生也要找消遣，也要社交，尽管那形式可能更加凝炼些。

The famp3er can work alone in the field or the woods all day, hoeing or chopping, and not feel lonesome, because he is employed; but when he comes home at night he cannot sit down in a room alone, at the mercy of his thoughts, but must be where he can :see the folks,: and recreate, and, as he thinks, remunerate himself for his day's solitude; and hence he wonders how the student can sit alone in the house all night and most of the day without ennui and :the blues:; but he does not realize that the student, though in the house, is still at work in his field, and chopping in his woods, as the famp3er in his, and in turn seeks the same recreation and society that the latter does, though it may be a more condensed fomp3 of it.

家人终日耕于田间，伐于山野，此时他虽孤单但并不寂寞，因他专心于工作；但待到他日暮而息，却未必能忍受形影相吊，空有思绪做伴的时光，他必到"可以看见大伙儿"的去处去找乐子，如他所认为的那样以补偿白日里的孤独；因此他无法理解学子如何能竟夜终日独坐而不心生厌倦或倍感凄凉；然而他没意识到，学子虽身在学堂，但心系劳作，但是耕于心田，伐于学林，这正和农人一样，学子在寻求的无非是和他一样的快乐与陪伴，只是形式更简洁罢了。

The farmer can work alone in thefield or the woods all day, hoeing or chopping, and not feel lonesome, becausehe is employed; but when he comes home at night he cannot sit down in a roomalone, at the mercy of his thoughts, but must be where he can see the folks, andrecreate, and, as he thinks, remunerate himself for his day's solitude; andhence he wonders how the student can sit alone in the house all night and mostof the day without ennui and the blues; but he does not realize that thestudent, though in the house, is still at work in his field, and chopping inhis woods, as the farmer in his, and in turn seeks the same recreation andsociety that the latter does, though it may be a more condensed form of it.

家人终日耕于田间，伐于山野，此时他虽孤单但并不寂寞，因他专心于工作；但待到他日暮而息，却未必能忍受形影相吊，空有思绪做伴的时光，他必到"可以看见大伙儿"的去处去找乐子，如他所认为的那样以补偿白日里的孤独；因此他无法理解学子如何能竟夜终日独坐而不心生厌倦或倍感凄凉；然而他没意识到，学子虽身在学堂，但心系劳作，但是耕于心田，伐于学林，这正和农人一样，学子在寻求的无非是和他一样的快乐与陪伴，只是形式更简洁罢了。

The farmer can work alone in the field or the woods all day,hoeing or chopping,and not feel lonesome,because he is employed;but when he comes home at night he cannot sit down in a room alone,at the mercy of his thoughts,but must be where he can "see the folks,"and recreate,and,as he thinks, remunerate himself for his day's solitude;and hence he wonders how the student can sit alone in the house all night and most of the day without ennui and "the blues";but he does not realize that the student,though in the house,is still at work in his field,and chopping in his woods,as the farmer in his,and in turn seeks the same recreation and society that the latter does,though it may be a more condensed form of it.

农夫终日耕于田间，伐于山野，此时他虽孤单但并不寂寞，因他专心于工作；但待到他日暮而息，却未必能忍受形影相吊，空有思绪做伴的时光，他必到"可以看见大伙儿"的去处找乐子，如他所认为的那样以补偿白日里的孤独；因此他无法理解学子如何能竟夜终日独坐而不心生厌倦或倍感凄凉；然而他没意识到，学子虽身在学堂，但心系劳作，他是耕于心田，伐于学林，这正和农夫一样，学子在寻求的无非是和他一样的快乐与陪伴，只是形式更简洁罢了。

The farmer can work alone in the field or the woods all day, hoeing or chopping, and not feel lonesome, because he is employed; but when he comes home at night he cannot sit down in a room alone, at the mercy of his thoughts, but must be where he can "see the folks," and recreate, and , as he thinks, remunerate himself for his day's solitude; and hence he wonders how the student can sit alone in the house all night and most of the day without ennui and "the blues"; but he does not realize that the student, though in the house, is still at work in his field, and chopping in his woods, as the farmer in his, and in turn seeks the same recreation and society that the latter does, though it may be a more condensed form of it. dedecms.com

农人终日耕于田间，伐于山野，此时他虽孤单但并不寂寞，因他专心于工作；但待到他日暮而息，却未必能忍受形影相吊、空有思绪作伴的时光，他必到"可以看见大伙儿"的去处去找乐子，如他所认为的那样以补偿白日里的孤独；因此他无法理解学子如何能竟夜终日独坐而不心生厌倦或倍感凄凉；然而他没意识到，学子虽身在学堂，但心系劳作，他是耕于心田，伐于学林，这正和农人一样，学子在寻求的无非是和他一样的快乐与陪伴，只是形式更简洁罢了。

I can go to stroke those many small shells, suppose there is any pearls in it; I can see a few sand crab ball rolling in the sea; I can with the small fish in the coral where they play hide and seek, look to find their surprised face when seeing them; really good fun!

我可以去轻抚一颗颗的小贝壳，猜想里面有没有珍珠；我可以看几只海蟹在海底的滚沙球；我可以跟小鱼们在珊瑚丛里玩玩捉迷藏，看看找到它们时它们那惊讶的表情；真是好好玩啊！

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。