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We further evaluated the synergistic cytotoxicity of TRAIL in combination with actinomycin D, cisplatin and paclitaxel in A549 cell lines in vitro and in vivo.
本实验选择了人肺腺癌A549细胞瘤株作为我们实验研究的对象,通过TRAIL对人肺腺癌A549细胞诱导凋亡研究,在A549的荷瘤裸鼠的动物模型上研究了其体内的抗肿瘤活性,并进一步研究了TRAIL与化疗药物放线菌素D(actinomycin D,Act D)、紫杉醇和顺铂(cisplatin,CDDP)的联合作用对人肺腺癌A549细胞的体外协同抗肿瘤活性,通过化疗药物协同增强TRAIL抗肿瘤活性作用机制的初步研究,为降低临床化疗药的用药量,减轻其对机体的不良反应提供一定的理论基础。
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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.
综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。
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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.
综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。
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The research progress on the formation of ordered molecular assembly in imidazolium ILs, such as liquid crystal, micelle, vesicle, microemulsion was reviewed. ILs can act as solvents, co-solvents, or surfactants to form liquid crystals. They also can be substituted for polar, apolar, or surfactant components in microemulsion to prepare various microemulsion systems ILs-in-oil, oil-in-ILs and bicontinuous B.
咪唑类离子液体可以作为溶剂、助溶剂和表面活性剂形成液晶;离子液体可以分别取代微乳液体系中的极性组分、非极性组分或表面活性剂,形成油包离子液体、离子液体包油和双连续的新型微乳液体系。
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The "Apologia" describes it, In every part of the country, and every class of society, through every organ and opportunity of opinion, in newspapers, in periodicals, at meetings, in pulpits, at dinner-tables, in coffee-rooms, in railway-carriages, I was denounced as a traitor who had laid his train, and was detected in the very act of firing it against the time-honoured Establishment.
" "纵容"形容,"在每一个国家的一部分,每一个阶层的社会,通过每一个器官和机会的意见,在报纸,期刊,会议上,在pulpits ,在晚宴上表,在咖啡室,在铁路车厢,我是谴责,作为一个汉奸谁奠定了他的列车,发现在非常的行为,这对射击的时间由来已久的建立。
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An allusion may be drawn from history, geography, literature, or religion. In Act One of Macbeth, Ross praises Macbeth's valor and skill in battle by referring to him as "Bellona's bridegroom". IN Roman mythology Bellona ws the goddess of war.
如麦克白第一幕中,罗斯称赞麦克白在战斗中的勇敢与高超技艺,称他是"贝娄娜的新郎",即是在引用典故,因为在罗马神话中,贝娄娜是战争女神。
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An allusion may be drawn from history, geography, literature, or religion. In Act One of Macbeth, Ross praises Macbeth's valor and skill in battle by referring to him as "Bellona'sbridegroom". IN Roman mythology Bellona ws the goddess of war.
如麦克白第一幕中,罗斯称赞麦克白在战斗中的勇敢与高超技艺,称他是"贝娄娜的新郎",即是在引用典故,因为在罗马神话中,贝娄娜是战争女神。
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Incident of bilk of this hauling sth resembling a net happens in about 10 a few days ago, QQ name is the cheater of dingdong atelier, it is a name in order to search project of game Zhang date, tens of individuals that contact through QQ installed a few class to act as agent.
这起网络诈骗事件发生在大约10日前,QQ名为叮当工作室的骗子,以寻找游戏账号项目为名,通过QQ联系到的数十个人设置了几级代理。
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In recent years, sever security accidents frequently arise in China, especially thecolliery industry, of which serious posture exists. To protect the secure of producing and managingmore efficiently, and to punish those who produce and manage with insecure elements, theAmendatory Act 6 makes amendments in this field. However, a imprecisely prescription wouldcause a inaccurately applying.
近几年,我国重特大安全事故频发,尤其是煤矿行业的安全生产形势非常严峻,为了更有效地维护生产经营的安全,惩治那些不重视对安全生产设施和安全生产条件进行投入、建设、管理和维护的行为,《刑法修正案》对重大劳动安全事故罪进行了修改,但是修改后的条文在犯罪构成要件的表述上不明确,在司法上不能得到准确适用。
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Currently our country of on-line bank the service is an additional net generally in the traditional bank the service up the service function, can provide the search, internal bank account funds of the search, bank account detail of the bank account surplus amount to transfer for the customer, foreign land telegraphic transfer, mail transfer, act for charge's etc. a basic finance a service, and net top shopping square, act for insurance, stock and foreign exchange bargain etc. comprehensive sex finance service.
目前我国的网上银行服务一般是在传统银行服务中附加网上服务功能,能够为客户提供帐户余额查询、帐户明细查询、内部帐户资金转移、异地电汇、信汇、代理收费等基本金融服务,以及网上购物广场、代理保险、股票及外汇交易等综合性金融服务。
- 推荐网络例句
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We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.
索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。
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The relationship between communicative competence and grammar teaching should be that of the ends and the means.
交际能力和语法的关系应该是目标与途径的关系。
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This is not paper type of business,it's people business,with such huge money involved.
这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。