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Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

In response to this situation VAI has recently developed the so-called MEROS process- standing for Maximized Emission Reduction Of Sintering in which dust and harmful metallic and organic components present in sinter offgas are removed in a series of treatment steps to levels previously unattained with conventional gas-treatment techniques. In a number of test campaigns conducted in a demonstration plant at voestalpine Stahl from 2005-2006, the technical and economical advantages of this innovative sinter offgas-cleaning process were verified.

基于这种情况，VAI近来开发出了一套名叫METRO的系统，能最大限度的减少烧结系统的排放，在这一系统中，烧结过程废气存在的粉尘、有害的金属物质和有机物质都在一系列的处理步骤中排除并且达到一定的水平，而这是传统的废气处理方法所无法达到的。2005到2006年间，在奥钢联位于澳大利亚林芝的实验厂里，进行了很多的试验，这一改革的烧结烟气净化处理系统的技术和经济优势得到了验证。

Three important conclusions are as follows:(1) the H2O content in garnet and omphacite can be up to 2000ppm and 3000ppm by weight respectively, indicating that they are significant carrier recycing surficial water into deep earth;(2) the heterogeneous distribution at the small scale of the H2O content and hydrogen isotopic ratios suggest that the whole subduction- exhumation process should be very fast;(3) the regular decrease of H2O content from rim to core within some garnet and omphacite grains indicates that hydrogen diffused out from mineral lattice during exhumation in response to sharp pressure decrease, and such hydrogen is expected to be involved in the early-stage retrograde metamorphism.

取得的主要科学认识包括：(1)石榴石和绿辉石的结构水含量可以分别高至2000ppm和3000ppm，这表明它们是板块俯冲过程中将地表水携带进地球深部的重要载体；(2)水含量和氢同位素组成表现出小尺度的不均一分布，说明板块的俯冲和折返过程是十分快速的；(3)在板块折返的早期，由于压力的降低，矿物中的H 会发生不同程度和尺度的扩散，这是早期退变质流体的重要来源。

To investigate the phenotypic plasticity in response to theheterogeneous soil water supply, ramet pairs of the species were subjected to heterogeneous watersupply by which either mother ramets or daughter ramets were in high or low soil water supply, respectively,in the Maowusu Sandy Land of Nei Mongol.

为了探讨拂子茅在异质性水分环境中的表型差异，在内蒙古鄂尔多斯高原的毛乌素沙地对拂子茅由母株、子株组成的分株对给予了高水、低水两种不同的异质性土壤水分处理。

Since 1961, Kai-lung completed metal surface treatment technology, the supply of high quality metal products industry to enhance productivity and reduce costs, etc., have made great progress; in order to enhance customer services and in response to the growing emphasis on the quality of the concept of social Kai Lung Company relocated three times, it is moved to the current Public Works:/ Tali City, Taichung County, 193 West Lake Road, and in October 2001 set up the Shenzhen factory.

自从1961年以来，启隆公司完成金属表面处理技术，供应金属工业界高品质产品，提升产量及降低成本等方面，已有长足的进步；为了提升对顾客的服务及因应品质观念日渐着重的社会，启隆公司经三次迁移，现移至目前所在工所：/台中县大里市西湖路193号，并于2001年十月成立深圳廠。

Shenzhen Kai-Long Machinery Co., Ltd. Since 1961, Kai-lung completed metal surface treatment technology, the supply of high quality metal products industry to enhance productivity and reduce costs, etc., have made great progress; in order to enhance customer services and in response to increasingly focus on the quality concepts of society, Kai Lung company relocated three times, it is moved to the current Public Works:/ Tali City, Taichung County, 193 West Lake Road, and in October 2001 set up the Shenzhen factory.

自从1961年以来，启隆公司完成金属表面处理技术，供应金属工业界高品质产品，提升产量及降低成本等方面，已有长足的进步；为了提升对顾客的服务及因应品质观念日渐着重的社会，启隆公司经三次迁移，现移至目前所在工所：/台中县大里市西湖路193号，并于2001年十月成立深圳廠。

NodD binds to and bends target promoters through anchoring two tandem and individual specific DNA sites. NodD functions as a tetramer, which has a V-shaped main body. Tetrameric NodD is to change its own conformation rather than its oligomeric forms in response to small signal molecules. The specific interaction between each NodD DNA-binding domain and each specific DNA site does not alter itself in spite of naringenin induction, and the induced conformational change is transferred from protein to DNA. Only the DNA conformation incited by induced NodD is competent for RNA polymerase to form the transcriptional open complex. It cannot be excluded that NodD may have protein-to-protein contacts with RNA polymerase, and that the NodD conformational change may also directly contribute to the transcriptional open complex formation. However, the NodD conformational change itself cannot serve as the determinant of the transcriptional molecular switch.

通过研究，我们提出了初步的NodD操纵子激活模型：第一，四聚体是NodD蛋白的功能单位，它通过铆钉两个串联的相对独立的DNA靶位点结合被诱导的启动子；第二，小分子配基的结合是改变NodD四聚体的构象而不是引发不同形式的寡聚体，在我们的模型中，NodD四聚体缩小其V形主体的弯折角，进而缩短其DNA结合功能域的间距；第三，小分子信号的诱导并没有改变NodD的DNA结合域和其DNA靶位点的相互作用，NodD的构象改变由蛋白质经其双铆钉位点传递给DNA；第四，只有诱导状态的NodD激发的DNA构象才能有效地使RNA聚合酶形成转录开放复合物；第五，不排除NodD与RNA聚合酶可能有直接的相互接触位点，不排除NodD构象的改变可能直接有利于RNA聚合酶形成转录开放复合物，但是我们认为NodD构象改变本身不是充当转录激活开关的决定因素。

Analytical formulae are presented for the first time to describe the shift in the resonance wavelength of LPG in response to etching of the fiber cladding or a change in the external refractive index. The accuracy of the formula is confirmed by comparision with numerical simulations and experimental results. We demonstrated that the resonance wavelengths of an etched LPG are more sensitive refractive index than those of an unetched grating. The bending properties of long period fiber grating written in different type fiber are studied experimentally. The transmission peaks and the central wavelength of LPG change with the bending of the fiber. A new peak appears at the shorter wavelength when the fiber is being bent. The changes of the peaks are different for different photosensitive fiber. Those properties have broad application foreground in fiber sensors and tunable filters.

分别从理论和实验上对长周期光栅的折射率特性以及光纤包层半径对长周期光栅特性的影响进行了研究，首次给出了描述光纤包层半径腐蚀和外界折射率改变与长周期光栅共振波长关系的理论表达式，实验与理论和数据模拟的结果很好符合，利用腐蚀光纤包层的方法可以有效地提高LPG的折射率灵敏度；对不同光纤中写入的长周期光栅的弯曲特性进行了实验研究，LPG的透射峰形状及其中心波长随光纤弯曲而发生变化，并且随着弯曲将在短波方向出现新的透射峰，其透射峰的变化规律因所用光敏光纤的不同而不同，这一特性在光纤传感和可调谐滤波器方面有重要的应用前景。

We call on you, in response to all those in Iran anxious about the fate of their loved ones, to urgently send a delegation to the cities of Iranian Kurdistan to investigate the human rights abuses by the regime; to inspect the prisons and meet with the prisoners, their families and the people of the cities, and in this way gain closer insight into the savageries of the Islamic Republic.

我们呼吁你，为了那些关心着他们所爱的人的命运的伊朗人民，立即派出一支代表团去伊朗库尔德人聚居地的城市，去调查那里侵犯人权的政权，去调查那里的监狱并会见那些囚犯、他们的家人和那里的市民，并通过这种方式更深入的观察伊斯兰共和国的暴行。

In response to what the Australian press has dubbed "the curry bashings", India's government has issued an advisory urging its nationals to take extra care in Australia's second-biggest city. The row has become so shrill it threatens to damage Australia's third-biggest export earner, after coal and iron ore: education, which brings in about A$17 billion ($16 billion) a year from foreigners.

澳大利亚媒体对这些事件轻描淡写，印度政府作出回应，就发出了一项建议性的警告，要国民在澳大利亚的第二大城市一定要小心谨慎，这可以说威胁到了澳大利亚第三大出口行业，教育仅次于媒和铁矿石为第三大，每年从外国人那里赚取170亿澳元。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。